دورية أكاديمية
[Small-cell lung cancer: epidemiology, diagnostics and therapy].
| العنوان: | [Small-cell lung cancer: epidemiology, diagnostics and therapy]. |
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| عنوان ترانسليتريتد: | Malobuněčný karcinom plic: epidemiologie, diagnostika a léčba. |
| المؤلفون: | Pešek M, Mužík J |
| المصدر: | Vnitrni lekarstvi [Vnitr Lek] Winter 2018; Vol. 63 (11), pp. 876-883. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | Czech |
| بيانات الدورية: | Publisher: Ambit Media Country of Publication: Czech Republic NLM ID: 0413602 Publication Model: Print Cited Medium: Print ISSN: 0042-773X (Print) Linking ISSN: 0042773X NLM ISO Abbreviation: Vnitr Lek Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2010- : Brno : Ambit Media Original Publication: 1973-<1994> : Praha : Avicenum |
| مواضيع طبية MeSH: | Lung Neoplasms*/therapy , Small Cell Lung Carcinoma*/therapy, Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Combined Modality Therapy/methods ; Humans ; Immunotherapy/methods ; Radiotherapy/methods |
| مستخلص: | Authors present actual overview of information on diagnostic and therapeutic procedures in small-cell lung cancer (SCLC). This highly aggressive type of lung cancer is diagnosed in 14.8 % of Czech lung cancer patients. Vast majority of those patients (87 %) suffer from advanced and metastatic disease in the time of diagnosis. In this issue are presented prognostic factors, staging diagnostic procedures and therapeutic recommendations. The backbone of actual SCLC treatment is combined chemotherapy and radiotherapy and less frequently, carefully in selected cases, surgical procedures. SCLC should be have as chemosensitive, chemoresistent or chemorefractory disease. Actual cytostatic combinations used in 1st line treatment, different schedules of chemoradiotherapy, drugs used in second line treatment and schedules and timing of prophylactic brain irradiation are presented. In near future, perspectively, there are some promissible data on antitumour immunotherapy based on anti CTLA-4 and anti PD-1/PE-L1 antibodies also in SCLC patients.Key words: cancer immunotherapy - concomitant chemoradiotherapy - chemotherapy - chest radiotherapy - lung resections - prophylactic brain irradiation - small cell lung cancer. |
| تواريخ الأحداث: | Date Created: 20180106 Date Completed: 20180417 Latest Revision: 20181202 |
| رمز التحديث: | 20231215 |
| PMID: | 29303289 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0042-773X |
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