دورية أكاديمية
Context-Dependent Requirements for FimH and Other Canonical Virulence Factors in Gut Colonization by Extraintestinal Pathogenic Escherichia coli.
العنوان: | Context-Dependent Requirements for FimH and Other Canonical Virulence Factors in Gut Colonization by Extraintestinal Pathogenic Escherichia coli. |
---|---|
المؤلفون: | Russell CW; University of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, Utah, USA., Fleming BA; University of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, Utah, USA., Jost CA; University of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, Utah, USA., Tran A; University of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, Utah, USA., Stenquist AT; University of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, Utah, USA., Wambaugh MA; University of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, Utah, USA., Bronner MP; Department of Pathology, ARUP Laboratories, University of Utah, Salt Lake City, Utah, USA.; Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Mulvey MA; University of Utah School of Medicine, Department of Pathology, Division of Microbiology and Immunology, Salt Lake City, Utah, USA mulvey@path.utah.edu. |
المصدر: | Infection and immunity [Infect Immun] 2018 Feb 20; Vol. 86 (3). Date of Electronic Publication: 2018 Feb 20 (Print Publication: 2018). |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Washington, DC : American Society For Microbiology Original Publication: [Bethesda, Md.] American Society for Microbiology. |
مواضيع طبية MeSH: | Adhesins, Escherichia coli/*metabolism , Escherichia coli Infections/*microbiology , Extraintestinal Pathogenic Escherichia coli/*metabolism , Fimbriae Proteins/*metabolism , Gastrointestinal Tract/*microbiology , Virulence Factors/*metabolism, Adhesins, Escherichia coli/genetics ; Animals ; Extraintestinal Pathogenic Escherichia coli/genetics ; Female ; Fimbriae Proteins/genetics ; Humans ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Virulence Factors/genetics |
مستخلص: | Extraintestinal pathogenic Escherichia coli (ExPEC) acts as a commensal within the mammalian gut but can induce pathology upon dissemination to other host environments such as the urinary tract and bloodstream. ExPEC genomes are likely shaped by evolutionary forces encountered within the gut, where the bacteria spend much of their time, provoking the question of how their extraintestinal virulence traits arose. The principle of coincidental evolution, in which a gene that evolved in one niche happens to be advantageous in another, has been used to argue that ExPEC virulence factors originated in response to selective pressures within the gut ecosystem. As a test of this hypothesis, the fitness of ExPEC mutants lacking canonical virulence factors was assessed within the intact murine gut in the absence of antibiotic treatment. We found that most of the tested factors, including cytotoxic necrotizing factor type 1 (CNF1), Usp, colibactin, flagella, and plasmid pUTI89, were dispensable for gut colonization. The deletion of genes encoding the adhesin PapG or the toxin HlyA had transient effects but did not interfere with longer-term persistence. In contrast, a mutant missing the type 1 pilus-associated adhesin FimH displayed somewhat reduced persistence within the gut. However, this phenotype varied dependent on the presence of specific competing strains and was partially attributable to aberrant flagellin expression in the absence of fimH These data indicate that FimH and other key ExPEC-associated factors are not strictly required for gut colonization, suggesting that the development of extraintestinal virulence traits is not driven solely by selective pressures within the gut. (Copyright © 2018 Russell et al.) |
References: | Infect Immun. 2005 Nov;73(11):7657-68. (PMID: 16239570) Infect Immun. 2001 Oct;69(10):6515-9. (PMID: 11553597) BMC Mol Biol. 2003 Dec 13;4:11. (PMID: 14672541) PLoS Pathog. 2009 Dec;5(12):e1000697. (PMID: 20019794) Mol Microbiol. 1998 Feb;27(4):751-61. (PMID: 9515701) J Clin Invest. 2007 Jun;117(6):1566-74. (PMID: 17525800) Epidemiol Infect. 1992 Jun;108(3):415-21. (PMID: 1350997) N Engl J Med. 2001 Oct 4;345(14):1007-13. (PMID: 11586952) Science. 2012 Oct 5;338(6103):120-3. (PMID: 22903521) Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16669-74. (PMID: 17925449) Eur J Clin Microbiol. 1982 Jun;1(3):186-92. (PMID: 6756909) Immunology. 2013 Jan;138(1):1-11. (PMID: 23240815) PLoS Pathog. 2015 Dec 04;11(12):e1005317. (PMID: 26636713) J Bacteriol. 2010 Oct;192(19):4885-93. (PMID: 20656906) Infect Immun. 2007 Jan;75(1):278-89. (PMID: 17074858) J Infect Dis. 2013 Nov 15;208(10):1545-52. (PMID: 23997234) Sci Rep. 2017 Mar 31;7:45649. (PMID: 28361997) J Bacteriol. 2007 May;189(9):3532-46. (PMID: 17351047) Microbiol Mol Biol Rev. 2016 Mar 02;80(2):351-67. (PMID: 26935136) Clin Infect Dis. 2013 Sep;57(5):719-24. (PMID: 23645845) Microbes Infect. 2006 Mar;8(3):834-40. (PMID: 16483819) Nature. 2012 Jun 13;486(7402):207-14. (PMID: 22699609) BMC Microbiol. 2014 Aug 28;14:203. (PMID: 25164788) Gut Pathog. 2013 Jun 10;5(1):13. (PMID: 23759109) Infect Immun. 2008 Jul;76(7):2978-90. (PMID: 18443089) Mol Microbiol. 1992 Mar;6(6):697-701. (PMID: 1349417) Infect Immun. 1989 Oct;57(10):3022-9. (PMID: 2570752) Mol Microbiol. 2001 Mar;39(5):1272-84. (PMID: 11251843) Infect Immun. 2005 Nov;73(11):7588-96. (PMID: 16239562) Gut Microbes. 2014 May-Jun;5(3):313-25. (PMID: 24971581) Cell Host Microbe. 2013 Nov 13;14(5):571-81. (PMID: 24237702) PLoS Med. 2007 Dec;4(12):e329. (PMID: 18092884) J Urol. 1997 Mar;157(3):1127-9. (PMID: 9072556) Science. 1997 Apr 25;276(5312):607-11. (PMID: 9110982) Microbiol Spectr. 2014 Oct;2(5):null. (PMID: 26104359) Infect Immun. 2005 Dec;73(12):8039-49. (PMID: 16299298) MBio. 2014 Oct 28;5(6):e02038. (PMID: 25352623) Gastroenterology. 2014 Nov;147(5):1055-63.e8. (PMID: 25046162) Nature. 2017 Jun 22;546(7659):528-532. (PMID: 28614296) J Infect Dis. 2002 May 15;185(10):1521-4. (PMID: 11992291) Infect Immun. 2010 Apr;78(4):1457-67. (PMID: 20123719) Mol Biol Evol. 2007 Nov;24(11):2373-84. (PMID: 17709333) Elife. 2015 Mar 25;4:null. (PMID: 25807083) Cell Microbiol. 2007 Oct;9(10):2530-40. (PMID: 17587334) Appl Environ Microbiol. 2013 Aug;79(16):5005-12. (PMID: 23770894) Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11537-42. (PMID: 20534522) Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5977-82. (PMID: 16585510) Microbiol Spectr. 2016 Jun;4(3):. (PMID: 27337488) Am J Epidemiol. 2002 Dec 15;156(12):1133-40. (PMID: 12480658) Infect Immun. 2007 Feb;75(2):932-40. (PMID: 17101646) Mol Immunol. 2006 Feb;43(4):378-87. (PMID: 16310051) Infect Immun. 1990 Sep;58(9):2957-61. (PMID: 2201640) Proc Natl Acad Sci U S A. 1995 Mar 14;92(6):2081-5. (PMID: 7892228) FEMS Microbiol Rev. 2016 Jul 1;40(4):437-463. (PMID: 28201713) Science. 2006 Aug 11;313(5788):848-51. (PMID: 16902142) J Infect Dis. 1992 Jan;165(1):46-52. (PMID: 1727897) EcoSal Plus. 2016 Jul;7(1):. (PMID: 27419387) Clin Diagn Lab Immunol. 2004 Mar;11(2):372-8. (PMID: 15013990) Infect Immun. 2012 Jun;80(6):1969-79. (PMID: 22473602) Biomolecules. 2014 Feb 18;4(1):217-34. (PMID: 24970213) Microb Pathog. 2000 Mar;28(3):183-9. (PMID: 10702359) Infect Immun. 2017 May 23;85(6):. (PMID: 28373355) J Urol. 2003 Dec;170(6 Pt 1):2490-3. (PMID: 14634457) J Infect Dis. 2014 Jul 15;210(2):285-94. (PMID: 24489107) Nat Commun. 2014 Sep 03;5:4724. (PMID: 25182170) Gut. 2014 Dec;63(12 ):1893-901. (PMID: 24534723) J Clin Microbiol. 2008 Aug;46(8):2529-34. (PMID: 18495863) Infect Immun. 1983 Mar;39(3):1300-6. (PMID: 6341235) Infect Immun. 2007 Jul;75(7):3315-24. (PMID: 17438023) Nucleic Acids Res. 2013 Dec;41(22):e204. (PMID: 24203710) PLoS One. 2010 Aug 11;5(8):e11882. (PMID: 20711443) Infect Immun. 2015 Aug;83(8):3243-56. (PMID: 26034214) PLoS Pathog. 2008 Dec;4(12):e1000233. (PMID: 19057665) Appl Environ Microbiol. 2011 Apr;77(7):2303-8. (PMID: 21317254) Inflamm Bowel Dis. 2007 Oct;13(10):1277-83. (PMID: 17476674) Cell Host Microbe. 2013 Jul 17;14(1):26-37. (PMID: 23870311) Infect Immun. 2015 Sep;83(9):3704-11. (PMID: 26150540) PLoS Genet. 2008 Jan;4(1):e2. (PMID: 18193944) PLoS Negl Trop Dis. 2017 May 22;11(5):e0005586. (PMID: 28531220) FEMS Microbiol Lett. 2007 Oct;275(2):255-62. (PMID: 17714479) Anaerobe. 1997 Apr-Jun;3(2-3):173-7. (PMID: 16887585) PLoS Pathog. 2012;8(10):e1002954. (PMID: 23055930) EMBO J. 2000 Apr 3;19(7):1450-7. (PMID: 10747013) Emerg Infect Dis. 1996 Apr-Jun;2(2):93-102. (PMID: 8903208) Nat Rev Microbiol. 2010 Mar;8(3):207-17. (PMID: 20157339) Toxicon. 1988;26(11):1047-56. (PMID: 3072687) Mol Microbiol. 1998 Oct;30(2):285-93. (PMID: 9791174) FEMS Immunol Med Microbiol. 2000 May;28(1):37-41. (PMID: 10767605) J Infect Dis. 2005 Apr 1;191(7):1078-83. (PMID: 15747243) PLoS Pathog. 2015 Mar 04;11(3):e1004697. (PMID: 25738819) Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5. (PMID: 10829079) Infect Immun. 2017 Oct 18;85(11):. (PMID: 28808163) Sci Transl Med. 2013 May 8;5(184):184ra60. (PMID: 23658245) Microbiology. 2006 Apr;152(Pt 4):1143-53. (PMID: 16549677) PLoS One. 2016 Apr 20;11(4):e0153034. (PMID: 27096607) J Bacteriol. 2007 Aug;189(15):5523-33. (PMID: 17513470) J Infect Dis. 1995 Aug;172(2):440-5. (PMID: 7622887) Infect Immun. 2005 Nov;73(11):7644-56. (PMID: 16239569) |
معلومات مُعتمدة: | R01 AI095647 United States AI NIAID NIH HHS |
فهرسة مساهمة: | Keywords: Escherichia coli; ExPEC; FimH; colonization; evolution; intestinal; microbiota; mouse model; uropathogenic; virulence factors |
المشرفين على المادة: | 0 (Adhesins, Escherichia coli) 0 (Virulence Factors) 0 (fimH protein, E coli) 147680-16-8 (Fimbriae Proteins) |
تواريخ الأحداث: | Date Created: 20180110 Date Completed: 20180919 Latest Revision: 20240213 |
رمز التحديث: | 20240213 |
مُعرف محوري في PubMed: | PMC5820936 |
DOI: | 10.1128/IAI.00746-17 |
PMID: | 29311232 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1098-5522 |
---|---|
DOI: | 10.1128/IAI.00746-17 |