دورية أكاديمية
Kartagener's syndrome: a case report.
| العنوان: | Kartagener's syndrome: a case report. |
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| المؤلفون: | Tadesse A; Department of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. abilo.tadesse@yahoo.com., Alemu H; Department of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia., Silamsaw M; Department of Internal Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia., Gebrewold Y; Department of Radiology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. |
| المصدر: | Journal of medical case reports [J Med Case Rep] 2018 Jan 10; Vol. 12 (1), pp. 5. Date of Electronic Publication: 2018 Jan 10. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101293382 Publication Model: Electronic Cited Medium: Internet ISSN: 1752-1947 (Electronic) Linking ISSN: 17521947 NLM ISO Abbreviation: J Med Case Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [London] : BioMed Central, [2007- |
| مواضيع طبية MeSH: | Bronchiectasis*/diagnosis , Bronchiectasis*/etiology , Bronchiectasis*/physiopathology , Bronchiectasis*/therapy , Dextrocardia*/diagnosis , Dextrocardia*/etiology , Kartagener Syndrome*/diagnosis , Kartagener Syndrome*/physiopathology , Kartagener Syndrome*/psychology , Kartagener Syndrome*/therapy , Quality of Life* , Sinusitis*/diagnosis , Sinusitis*/drug therapy , Sinusitis*/etiology , Situs Inversus*/diagnosis , Situs Inversus*/etiology, Anti-Bacterial Agents/*administration & dosage , Expectorants/*administration & dosage, Breathing Exercises/methods ; Chronic Disease ; Diagnosis, Differential ; Genetic Counseling ; Humans ; Male ; Patient Care Management/methods ; Young Adult |
| مستخلص: | Background: Kartagener's syndrome is a subset of primary ciliary dyskinesia, an autosomal recessive inherited disorder characterized by the clinical triad of chronic sinusitis, bronchiectasis, and situs inversus. Abnormal ciliary structure or function leading to impaired ciliary motility is the main pathophysiologic problem in Kartagener's syndrome. Case Presentation: A 24-year-old man from Gondar town, North-West Ethiopia, presented to University of Gondar Hospital with recurrent episodes of nasal congestion with itching and paranasal discomfort, and productive cough for more than a decade. Clinical and imaging findings revealed chronic sinusitis, bronchiectasis, dextrocardia, and situs inversus. He was treated with orally administered antibiotics, mucolytic, and chest physiotherapy. He was symptomatically better with the above therapy, and started on a long-term low-dose prophylactic antibiotic. Conclusions: Patients with Kartagener's syndrome exist in Ethiopia as cases of chronic recurrent sinopulmonary infections. As there is no easy, reliable non-invasive diagnostic test for Kartagener's syndrome and the correct diagnosis is often delayed by years, it may cause chronic respiratory problems with reduced quality of life. Genetic counseling and fertility issues should be addressed once Kartagener's syndrome is diagnosed. |
| References: | Am Rev Respir Dis. 1975 Dec;112(6):807-9. (PMID: 1081860) J Allergy Clin Immunol. 2003 Sep;112(3):518-24. (PMID: 13679810) Ethiop Med J. 2016 Apr;54(2):91-4. (PMID: 27476230) N Engl J Med. 1977 Jul 7;297(1):1-6. (PMID: 301245) |
| فهرسة مساهمة: | Keywords: Bronchiectasis; Chronic sinusitis; Kartagener’s syndrome; Primary ciliary dyskinesia; Situs inversus |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Expectorants) |
| تواريخ الأحداث: | Date Created: 20180111 Date Completed: 20180815 Latest Revision: 20181113 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5761107 |
| DOI: | 10.1186/s13256-017-1538-2 |
| PMID: | 29316973 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1752-1947 |
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| DOI: | 10.1186/s13256-017-1538-2 |