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Genome Wide Mapping of Peptidases in Rhodnius prolixus : Identification of Protease Gene Duplications, Horizontally Transferred Proteases and Analysis of Peptidase A1 Structures, with Considerations on Their Role in the Evolution of Hematophagy in Triatominae.

التفاصيل البيبلوغرافية
العنوان: Genome Wide Mapping of Peptidases in Rhodnius prolixus : Identification of Protease Gene Duplications, Horizontally Transferred Proteases and Analysis of Peptidase A1 Structures, with Considerations on Their Role in the Evolution of Hematophagy in Triatominae.
المؤلفون: Henriques BS; Laboratory of Insect Physiology and Biochemistry, Oswaldo Cruz Institute - Oswaldo Cruz Foundation (IOC-FIOCRUZ), Rio de Janeiro, Brazil., Gomes B; Laboratory of Insect Physiology and Biochemistry, Oswaldo Cruz Institute - Oswaldo Cruz Foundation (IOC-FIOCRUZ), Rio de Janeiro, Brazil., da Costa SG; Laboratory of Insect Physiology and Biochemistry, Oswaldo Cruz Institute - Oswaldo Cruz Foundation (IOC-FIOCRUZ), Rio de Janeiro, Brazil., Moraes CDS; Laboratory of Insect Physiology and Biochemistry, Oswaldo Cruz Institute - Oswaldo Cruz Foundation (IOC-FIOCRUZ), Rio de Janeiro, Brazil., Mesquita RD; National Institute of Science and Technology for Molecular Entomology (INCT-EM), Cidade Universitária, Rio de Janeiro, Brazil.; Chemistry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Dillon VM; Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom., Garcia ES; Laboratory of Insect Physiology and Biochemistry, Oswaldo Cruz Institute - Oswaldo Cruz Foundation (IOC-FIOCRUZ), Rio de Janeiro, Brazil.; National Institute of Science and Technology for Molecular Entomology (INCT-EM), Cidade Universitária, Rio de Janeiro, Brazil., Azambuja P; Laboratory of Insect Physiology and Biochemistry, Oswaldo Cruz Institute - Oswaldo Cruz Foundation (IOC-FIOCRUZ), Rio de Janeiro, Brazil.; National Institute of Science and Technology for Molecular Entomology (INCT-EM), Cidade Universitária, Rio de Janeiro, Brazil., Dillon RJ; Division of Biomedical and Life Sciences, Lancaster University, Lancaster, United Kingdom., Genta FA; Laboratory of Insect Physiology and Biochemistry, Oswaldo Cruz Institute - Oswaldo Cruz Foundation (IOC-FIOCRUZ), Rio de Janeiro, Brazil.; National Institute of Science and Technology for Molecular Entomology (INCT-EM), Cidade Universitária, Rio de Janeiro, Brazil.
المصدر: Frontiers in physiology [Front Physiol] 2017 Dec 12; Vol. 8, pp. 1051. Date of Electronic Publication: 2017 Dec 12 (Print Publication: 2017).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Frontiers Research Foundation
مستخلص: Triatominae is a subfamily of the order Hemiptera whose species are able to feed in the vertebrate blood (i.e., hematophagy). This feeding behavior presents a great physiological challenge to insects, especially in Hemipteran species with a digestion performed by lysosomal-like cathepsins instead of the more common trypsin-like enzymes. With the aim of having a deeper understanding of protease involvement in the evolutionary adaptation for hematophagy in Hemipterans, we screened peptidases in the Rhodnius prolixus genome and characterized them using common blast (NCBI) and conserved domain analyses (HMMER/blast manager software, FAT, plus PFAM database). We compared the results with available sequences from other hemipteran species and with 18 arthropod genomes present in the MEROPS database. Rhodnius prolixus contains at least 433 protease coding genes, belonging to 71 protease families. Seven peptidase families in R. prolixus presented higher gene numbers when compared to other arthropod genomes. Further analysis indicated that a gene expansion of the protease family A1 (Eukaryotic aspartyl protease, PF00026) might have played a major role in the adaptation to hematophagy since most of these peptidase genes seem to be recently acquired, are expressed in the gut and present putative secretory pathway signal peptides. Besides that, most R. prolixus A1 peptidases showed high frequencies of basic residues at the protein surface, a typical structural signature of Cathepsin D-like proteins. Other peptidase families expanded in R. prolixus (i.e., C2 and M17) also presented significant differences between hematophagous (higher number of peptidases) and non-hematophagous species. This study also provides evidence for gene acquisition from microorganisms in some peptidase families in R. prolixus : (1) family M74 (murein endopeptidase), (2) family S29 (Hepatitis C virus NS3 protease), and (3) family S24 (repressor LexA). This study revealed new targets for studying the adaptation of these insects for digestion of blood meals and their competence as vectors of Chagas disease.
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فهرسة مساهمة: Keywords: Rhodnius prolixus; blood feeding; gene transfer; genome; insect; peptidase
تواريخ الأحداث: Date Created: 20180113 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5736985
DOI: 10.3389/fphys.2017.01051
PMID: 29326597
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-042X
DOI:10.3389/fphys.2017.01051