دورية أكاديمية
Diurnal pattern in skin Na + and water content is associated with salt-sensitive hypertension in ET B receptor-deficient rats.
العنوان: | Diurnal pattern in skin Na + and water content is associated with salt-sensitive hypertension in ET |
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المؤلفون: | Speed JS; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi., Hyndman KA; Cardio-Renal Physiology and Medicine, Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, Alabama., Kasztan M; Cardio-Renal Physiology and Medicine, Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, Alabama., Johnston JG; Cardio-Renal Physiology and Medicine, Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, Alabama., Roth KJ; Cardio-Renal Physiology and Medicine, Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, Alabama., Titze JM; Cardiovasular and Metabolic Disorders, National University of Singapore Medical School, Singapore., Pollock DM; Cardio-Renal Physiology and Medicine, Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, Alabama. |
المصدر: | American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2018 Apr 01; Vol. 314 (4), pp. R544-R551. Date of Electronic Publication: 2017 Dec 13. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Bethesda, Md. : American Physiological Society |
مواضيع طبية MeSH: | Arterial Pressure* , Circadian Rhythm*, Body Water/*metabolism , Hypertension/*metabolism , Receptor, Endothelin B/*deficiency , Skin/*metabolism , Sodium Chloride, Dietary/*metabolism, Animals ; Disease Models, Animal ; Endothelin-1/metabolism ; Hypertension/genetics ; Hypertension/physiopathology ; Male ; Rats, Transgenic ; Receptor, Endothelin B/genetics ; Signal Transduction ; Time Factors |
مستخلص: | Impairment in the ability of the skin to properly store Na + nonosmotically (without water) has recently been hypothesized as contributing to salt-sensitive hypertension. Our laboratory has shown that endothelial production of endothelin-1 (ET-1) is crucial to skin Na + handling. Furthermore, it is well established that loss of endothelin type B receptor (ET |
التعليقات: | Comment in: Am J Physiol Regul Integr Comp Physiol. 2018 Apr 1;314(4):R542-R543. (PMID: 29351424) |
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معلومات مُعتمدة: | K01 DK105038 United States DK NIDDK NIH HHS; P30 DK056336 United States DK NIDDK NIH HHS; T32 GM008111 United States GM NIGMS NIH HHS; P01 HL136267 United States HL NHLBI NIH HHS; R00 HL127178 United States HL NHLBI NIH HHS |
فهرسة مساهمة: | Keywords: circadian rhythm; endothelin; salt; skin; sodium |
المشرفين على المادة: | 0 (Endothelin-1) 0 (Receptor, Endothelin B) 0 (Sodium Chloride, Dietary) 0 (ednrb protein, rat) |
تواريخ الأحداث: | Date Created: 20180120 Date Completed: 20190114 Latest Revision: 20200930 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5966816 |
DOI: | 10.1152/ajpregu.00312.2017 |
PMID: | 29351432 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1522-1490 |
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DOI: | 10.1152/ajpregu.00312.2017 |