دورية أكاديمية
أعرض في EDS

Diurnal pattern in skin Na + and water content is associated with salt-sensitive hypertension in ET B receptor-deficient rats.

التفاصيل البيبلوغرافية
العنوان: Diurnal pattern in skin Na + and water content is associated with salt-sensitive hypertension in ET B receptor-deficient rats.
المؤلفون: Speed JS; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi., Hyndman KA; Cardio-Renal Physiology and Medicine, Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, Alabama., Kasztan M; Cardio-Renal Physiology and Medicine, Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, Alabama., Johnston JG; Cardio-Renal Physiology and Medicine, Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, Alabama., Roth KJ; Cardio-Renal Physiology and Medicine, Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, Alabama., Titze JM; Cardiovasular and Metabolic Disorders, National University of Singapore Medical School, Singapore., Pollock DM; Cardio-Renal Physiology and Medicine, Department of Medicine, Division of Nephrology, University of Alabama at Birmingham , Birmingham, Alabama.
المصدر: American journal of physiology. Regulatory, integrative and comparative physiology [Am J Physiol Regul Integr Comp Physiol] 2018 Apr 01; Vol. 314 (4), pp. R544-R551. Date of Electronic Publication: 2017 Dec 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1490 (Electronic) Linking ISSN: 03636119 NLM ISO Abbreviation: Am J Physiol Regul Integr Comp Physiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bethesda, Md. : American Physiological Society
مواضيع طبية MeSH: Arterial Pressure* , Circadian Rhythm*, Body Water/*metabolism , Hypertension/*metabolism , Receptor, Endothelin B/*deficiency , Skin/*metabolism , Sodium Chloride, Dietary/*metabolism, Animals ; Disease Models, Animal ; Endothelin-1/metabolism ; Hypertension/genetics ; Hypertension/physiopathology ; Male ; Rats, Transgenic ; Receptor, Endothelin B/genetics ; Signal Transduction ; Time Factors
مستخلص: Impairment in the ability of the skin to properly store Na + nonosmotically (without water) has recently been hypothesized as contributing to salt-sensitive hypertension. Our laboratory has shown that endothelial production of endothelin-1 (ET-1) is crucial to skin Na + handling. Furthermore, it is well established that loss of endothelin type B receptor (ET B ) receptor function impairs Na + excretion by the kidney. Thus we hypothesized that rats lacking functional ET B receptors (ET B -def) will have a reduced capacity of the skin to store Na + during chronic high-salt (HS) intake. We observed that ET B -def rats exhibited salt-sensitive hypertension with an approximate doubling in the diurnal amplitude of mean arterial pressure compared with genetic control rats on a HS diet. Two weeks of HS diet significantly increased skin Na + content relative to water; however, there was no significant difference between control and ET B -def rats. Interestingly, HS intake led to a 19% increase in skin Na + and 16% increase in water content (relative to dry wt.) during the active phase (zeitgeber time 16) versus inactive phase (zeitgeber time 4, P < 0.05) in ET B -def rats. There was no significant circadian variation in total skin Na + or water content of control rats fed normal or HS. These data indicate that ET B receptors have little influence on the ability to store Na + nonosmotically in the skin during long-term HS intake but, rather, appear to regulate diurnal rhythms in skin Na + content and circadian blood pressure rhythms associated with a HS diet.
التعليقات: Comment in: Am J Physiol Regul Integr Comp Physiol. 2018 Apr 1;314(4):R542-R543. (PMID: 29351424)
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معلومات مُعتمدة: K01 DK105038 United States DK NIDDK NIH HHS; P30 DK056336 United States DK NIDDK NIH HHS; T32 GM008111 United States GM NIGMS NIH HHS; P01 HL136267 United States HL NHLBI NIH HHS; R00 HL127178 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: circadian rhythm; endothelin; salt; skin; sodium
المشرفين على المادة: 0 (Endothelin-1)
0 (Receptor, Endothelin B)
0 (Sodium Chloride, Dietary)
0 (ednrb protein, rat)
تواريخ الأحداث: Date Created: 20180120 Date Completed: 20190114 Latest Revision: 20200930
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5966816
DOI: 10.1152/ajpregu.00312.2017
PMID: 29351432
قاعدة البيانات: MEDLINE
الوصف
تدمد:1522-1490
DOI:10.1152/ajpregu.00312.2017