دورية أكاديمية
Role of organic acids in the integration of cellular redox metabolism and mediation of redox signalling in photosynthetic tissues of higher plants.
| العنوان: | Role of organic acids in the integration of cellular redox metabolism and mediation of redox signalling in photosynthetic tissues of higher plants. |
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| المؤلفون: | Igamberdiev AU; Department of Biology, Memorial University of Newfoundland, St. John's, NL, Canada A1B 3X9. Electronic address: igamberdiev@mun.ca., Bykova NV; Morden Research and Development Centre, Agriculture and Agri-Food Canada, Morden, MB, Canada R6M 1Y5. |
| المصدر: | Free radical biology & medicine [Free Radic Biol Med] 2018 Jul; Vol. 122, pp. 74-85. Date of Electronic Publication: 2018 Jan 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Science Original Publication: New York : Pergamon, c1987- |
| مواضيع طبية MeSH: | Malate Dehydrogenase (NADP+)/*metabolism , Mitochondrial Proteins/*chemistry , Oxidoreductases/*chemistry , Plant Proteins/*chemistry, Arabidopsis/chemistry ; Arabidopsis/metabolism ; Chloroplasts/chemistry ; Chloroplasts/metabolism ; Malate Dehydrogenase (NADP+)/chemistry ; Malates/chemistry ; Malates/metabolism ; Mitochondria/chemistry ; Mitochondria/metabolism ; Mitochondrial Proteins/genetics ; Oxidation-Reduction ; Oxidoreductases/genetics ; Photosynthesis/genetics ; Plant Leaves/chemistry ; Plant Leaves/metabolism ; Plant Proteins/genetics ; Signal Transduction/genetics |
| مستخلص: | Organic acids play a crucial role in numerous metabolic processes accompanied by transfer of electrons and protons and linked to the reduction/oxidation of major redox couples in plant cells, such as NAD, NADP, glutathione, and ascorbate. Fluxes through the pathways metabolizing organic acids modulate redox states in cell compartments, contribute to generation of reactive oxygen and nitrogen species, and mediate signal transduction processes. Organic acid metabolism not only functions to equilibrate the redox potential in plant cells but also to transfer redox equivalents between cell compartments supporting various metabolic processes. The most important role in this transfer belongs to different forms of malate dehydrogenase interconverting malate and oxaloacetate or forming pyruvate (malic enzymes). During photosynthesis malate serves as a major form of transfer of redox equivalents from chloroplasts to the cytosol and other compartments via the malate valve. On the other hand, mitochondria, via alterations of their redox potential, become a source of citrate that can be transported to the cytosol and support biosynthesis of amino acids. Citrate is also an important retrograde signalling compound that regulates transcription of several genes including those encoding the alternative oxidase. The alternative oxidase, which is activated by increased redox potential and by pyruvate, is, in turn, important for the maintenance of redox potential in mitochondria. The roles of organic acids in establishing redox equilibrium, supporting ionic gradients on membranes, acidification of the extracellular medium, and regulation of production of reactive oxygen and nitrogen species are discussed. (Copyright © 2018 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Citrate; Malate; Organic acids; Reactive nitrogen species; Reactive oxygen species; Redox potential |
| المشرفين على المادة: | 0 (Malates) 0 (Mitochondrial Proteins) 0 (Plant Proteins) 817L1N4CKP (malic acid) EC 1.- (Oxidoreductases) EC 1.- (alternative oxidase) EC 1.1.1.82 (Malate Dehydrogenase (NADP+)) |
| تواريخ الأحداث: | Date Created: 20180123 Date Completed: 20190719 Latest Revision: 20190719 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.freeradbiomed.2018.01.016 |
| PMID: | 29355740 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4596 |
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| DOI: | 10.1016/j.freeradbiomed.2018.01.016 |