دورية أكاديمية
أعرض في EDS

Metabolic plasticity in development: Synergistic responses to high temperature and hypoxia in zebrafish, Danio rerio.

التفاصيل البيبلوغرافية
العنوان: Metabolic plasticity in development: Synergistic responses to high temperature and hypoxia in zebrafish, Danio rerio.
المؤلفون: Pan TF; Department of Biological Sciences, University of North Texas, Denton, Texas., Hunt von Herbing I; Department of Biological Sciences, University of North Texas, Denton, Texas.
المصدر: Journal of experimental zoology. Part A, Ecological and integrative physiology [J Exp Zool A Ecol Integr Physiol] 2017 Apr; Vol. 327 (4), pp. 189-199. Date of Electronic Publication: 2017 Aug 27.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Wiley Periodicals, Inc Country of Publication: United States NLM ID: 101710204 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2471-5646 (Electronic) Linking ISSN: 24715638 NLM ISO Abbreviation: J Exp Zool A Ecol Integr Physiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hoboken, NJ : Wiley Periodicals, Inc., [2017]
مواضيع طبية MeSH: Hot Temperature*, Energy Metabolism/*physiology , Oxygen/*metabolism , Zebrafish/*growth & development, Animals ; Larva/physiology ; Oxygen Consumption/physiology
مستخلص: This study investigated interactions of temperature and hypoxia on metabolic plasticity and regulation in zebrafish, Danio rerio, in the first week of development. Larval morphometry, oxygen consumption, and metabolic responses to acute changes in temperature and oxygen were measured in larvae reared under four conditions, including control (28°C and partial pressures of oxygen [PO 2 ] of 21 kPa), high temperature (31°C), hypoxia (11 kPa), and the two stressors combined. Rearing conditions did not result in consistent morphometric changes; substantial metabolic adjustments, however, were evident. While acute temperature increase resulted in elevated oxygen consumption, with a Q 10 of 2.2 ± 0.08, early-staged larvae were able to compensate to chronic temperature rise as routine metabolic rates did not differ between 28°C and 31°C chronic treatments. In contrast, larval responses to chronic and acute hypoxia were similar, with ∼30% decrease in metabolic rates from normoxic values at both temperatures. Further, prior exposure to chronic hypoxia in conjunction with acute high temperature increased Q 10 by a factor of 2.5 from 2.2 ± 0.08 to 5.6 ± 0.19. Metabolic suppression by acute hypoxia was independent of any prior exposure conditions. In short, results from this study showed that zebrafish larvae exhibited surprising temperature resilience and metabolic plasticity to a 3°C temperature rise even in their first week of life. Yet exposure to a second stressor (hypoxia) resulted in elevated sensitivity to temperature change that may lead to bioenergetic imbalance due to synergetic effects of temperature and hypoxia on metabolic rates.
(© 2017 Wiley Periodicals, Inc.)
فهرسة مساهمة: Keywords: development; hypoxia; morphometry; oxygen consumption; temperature; zebrafish
المشرفين على المادة: S88TT14065 (Oxygen)
تواريخ الأحداث: Date Created: 20180123 Date Completed: 20190122 Latest Revision: 20190122
رمز التحديث: 20221213
DOI: 10.1002/jez.2092
PMID: 29356379
قاعدة البيانات: MEDLINE
الوصف
تدمد:2471-5646
DOI:10.1002/jez.2092