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Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage.

التفاصيل البيبلوغرافية
العنوان: Gastroprotective Effects of Sulphated Polysaccharides from the Alga Caulerpa mexicana Reducing Ethanol-Induced Gastric Damage.
المؤلفون: Carneiro JG; Department of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil. gerardo@ifce.edu.br.; Federal Institute of Education, Science and Technology of Ceará, Armando Sales Louzada Street, 62580-000 Acaraú, Brazil. gerardo@ifce.edu.br., Holanda TBL; Department of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil., Quinderé ALG; Department of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil. aninhaquindere@gmail.com., Frota AF; Department of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil. annyta.frota@gmail.com., Soares VVM; Department of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil. vitoriabio8@gmail.com., Sousa RS; Department of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil. ticipesca@yahoo.com.br., Carneiro MA; Department of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil. manuela.carneiro@hotmail.com., Martins DS; Department of Morphoology, Faculty of Medicine, Federal University of Ceará, s/n Delmiro de Farias Street, Porangabuçu Campus, 60416-030 Fortaleza, Brazil. dainy.santos@gmail.com., Gomes Duarte AS; Department of Morphoology, Faculty of Medicine, Federal University of Ceará, s/n Delmiro de Farias Street, Porangabuçu Campus, 60416-030 Fortaleza, Brazil. asouzagomes@yahoo.com.br., Benevides NMB; Department of Biochemistry and Molecular Biology, Federal University of Ceará, s/n Humberto Monte Avenue, Pici Campus, 60455-760 Fortaleza, Brazil. nmbb@ufc.br.
المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2018 Jan 20; Vol. 11 (1). Date of Electronic Publication: 2018 Jan 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c2004-
مستخلص: The development of the gastric lesion is complex and the result of the imbalance between aggressive and protective factors, involving the generation of free radicals and disturbance in nitric oxide (NO) production. Sulphated polysaccharides (SP), from marine algae, are widely used in biotechnological and pharmaceutical areas. In this study, we evaluated the effects of SP from the green marine alga Caulerpa mexicana (Cm-SP) in ethanol-induced gastric damage models in mice. Cm-SP (2, 20, or 200 mg/kg), administered p.o., significantly reduced gastric damage, and these effects were inhibited through pretreatment with indomethacin. Cm-SP (200 mg/kg) prevented the ethanol-induced decline in glutathione and restored its normal level. Moreover, it was able to normalize the elevated thiobarbituric acid reactive substance levels. However, Cm-SP did not show any significant effects on NO₂/NO₃ level, when compared to the ethanol group. The pretreatment with L- NAME induced gastric mucosal damage and did not inhibit the gastroprotective effect of Cm-SP (200 mg/kg). In conclusion, the gastroprotective effects of Cm-SP in mice involve prostaglandins and reduction in the oxidative stress and are independent of NO.
Competing Interests: The authors declare no conflict of interest.
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فهرسة مساهمة: Keywords: cytoprotection; gastric ulcer; gastroprotection; marine alga
تواريخ الأحداث: Date Created: 20180125 Latest Revision: 20200930
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5874702
DOI: 10.3390/ph11010006
PMID: 29361672
قاعدة البيانات: MEDLINE
الوصف
تدمد:1424-8247
DOI:10.3390/ph11010006