دورية أكاديمية
Alterations in Metabolism and Diurnal Rhythms following Bilateral Surgical Removal of the Superior Cervical Ganglia in Rats.
| العنوان: | Alterations in Metabolism and Diurnal Rhythms following Bilateral Surgical Removal of the Superior Cervical Ganglia in Rats. |
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| المؤلفون: | Mul Fedele ML; Science and Technology, Universidad Nacional de Quilmes (UNQ), Bernal, Argentina., Galiana MD; Institute of Histology and Embryology of Mendoza (IHEM-CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina., Golombek DA; Science and Technology, Universidad Nacional de Quilmes (UNQ), Bernal, Argentina., Muñoz EM; Institute of Histology and Embryology of Mendoza (IHEM-CONICET), Universidad Nacional de Cuyo, Mendoza, Argentina., Plano SA; Science and Technology, Universidad Nacional de Quilmes (UNQ), Bernal, Argentina.; Chronophysiology Laboratory, Institute for Biomedical Research (BIOMED-CONICET), UCA Pontificia Universidad Católica Argentina, Buenos Aires, Argentina. |
| المصدر: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2018 Jan 09; Vol. 8, pp. 370. Date of Electronic Publication: 2018 Jan 09 (Print Publication: 2017). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مستخلص: | Mammalian circadian rhythms are controlled by a master pacemaker located in the suprachiasmatic nuclei (SCN), which is synchronized to the environment by photic and nonphotic stimuli. One of the main functions of the SCN is to regulate peripheral oscillators to set temporal variations in the homeostatic control of physiology and metabolism. In this sense, the SCN coordinate the activity/rest and feeding/fasting rhythms setting the timing of food intake, energy expenditure, thermogenesis, and active and basal metabolism. One of the major time cues to the periphery is the nocturnal melatonin, which is synthesized and secreted by the pineal gland. Under SCN control, arylalkylamine N -acetyltransferase (AA-NAT)-the main enzyme regulating melatonin synthesis in vertebrates-is activated at night by sympathetic innervation that includes the superior cervical ganglia (SCG). Bilateral surgical removal of the superior cervical ganglia (SCGx) is considered a reliable procedure to completely prevent the nocturnal AA-NAT activation, irreversibly suppressing melatonin rhythmicity. In the present work, we studied the effects of SCGx on rat metabolic parameters and diurnal rhythms of feeding and locomotor activity. We found a significant difference between SCGx and sham-operated rats in metabolic variables such as an increased body weight/food intake ratio, increased adipose tissue, and decreased glycemia with a normal glucose tolerance. An analysis of locomotor activity and feeding rhythms showed an increased daytime (lights on) activity (including food consumption) in the SCGx group. These alterations suggest that superior cervical ganglia-related feedback mechanisms play a role in SCN-periphery phase coordination and that SCGx is a valid model without brain-invasive surgery to explore how sympathetic innervation affects daily (24 h) patterns of activity, food consumption and, ultimately, its role in metabolism homeostasis. |
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| فهرسة مساهمة: | Keywords: SCGx; circadian rhythm; melatonin; metabolism; superior cervical ganglion |
| تواريخ الأحداث: | Date Created: 20180130 Latest Revision: 20191120 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5767240 |
| DOI: | 10.3389/fendo.2017.00370 |
| PMID: | 29375476 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-2392 |
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| DOI: | 10.3389/fendo.2017.00370 |