دورية أكاديمية
Usefulness of molecular diagnosis in egg allergic children.
العنوان: | Usefulness of molecular diagnosis in egg allergic children. |
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المؤلفون: | Petrosino MI; Department of Pediatrics, University of Chieti, Chieti, Italy., Scaparrotta A; Department of Pediatrics, University of Chieti, Chieti, Italy., Marcovecchio ML; Department of Pediatrics, University of Chieti, Chieti, Italy., Panichi D; Department of Pediatrics, University of Chieti, Chieti, Italy., Rapino D; Department of Pediatrics, University of Chieti, Chieti, Italy., Attanasi M; Department of Pediatrics, University of Chieti, Chieti, Italy., Filippo PD; Department of Pediatrics, University of Chieti, Chieti, Italy., Pillo SD; Department of Pediatrics, University of Chieti, Chieti, Italy., Chiarelli F; Department of Pediatrics, University of Chieti, Chieti, Italy. |
المصدر: | Archives of medical science : AMS [Arch Med Sci] 2018 Jan; Vol. 14 (1), pp. 132-137. Date of Electronic Publication: 2016 Mar 23. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Termedia Pub. House Country of Publication: Poland NLM ID: 101258257 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1734-1922 (Print) Linking ISSN: 17341922 NLM ISO Abbreviation: Arch Med Sci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: [Poznań, Poland] : Termedia Pub. House, [2005]- |
مستخلص: | Introduction: Egg allergy is one of the most common food allergies in children. Egg white, including ovomucoid (OVM or Gal d 1) and ovalbumin (OVA or Gal d 2), is the major source of allergens. The aim of this study was to assess the role of Gal d 1 and Gal d 2 in predicting the risk of anaphylaxis caused by eggs in children, and to compare this new diagnostic tool with established methods of allergen-specific IgE detection. Material and Methods: One hundred and forty-eight children were divided into 2 groups according to a positive (group A, 33 children) or negative (group B, 115 children) history of anaphylaxis after ingestion/contact with eggs. All patients underwent an allergological evaluation by measurements of specific IgE against egg white: Gal d 1 and Gal d 2. Results: Higher levels of Gal d 1, Gal d 2 and IgE against egg white were detected in group A compared to group B ( p < 0.001). Although the area under the curve was similar for Gal d 1 and Gal d 2, egg white specific IgE showed a better sensitivity (85%) for a cut-off value ≥ 0.975 kUA/l, while Gal d 1 and Gal d 2 demonstrated a better specificity (90% and 80%, respectively) for cut-off values ≥ 1.460 kUA/l and ≥ 2.310 kUA/l, respectively. Conclusions: Egg white specific IgE showed a similar ability as Gal d 1 and Gal d 2 in differentiating children at risk for egg anaphylaxis, although Gal d 1 and Gal d 2 showed a better specificity. |
References: | Allergy. 2008 Nov;63(11):1521-8. (PMID: 18925888) Pediatr Allergy Immunol. 2010 Jun;21(4 Pt 1):634-9. (PMID: 19943913) J Allergy Clin Immunol. 2008 Sep;122(3):583-8. (PMID: 18692888) Curr Allergy Asthma Rep. 2006 Mar;6(2):145-52. (PMID: 16566865) Allergy. 2010 Mar;65(3):283-9. (PMID: 19912153) J Allergy Clin Immunol. 1997 Aug;100(2):171-6. (PMID: 9275136) ISRN Allergy. 2012 Feb 09;2012:627545. (PMID: 23724243) J Immunol. 1997 Aug 15;159(4):2026-32. (PMID: 9257870) Am J Epidemiol. 2006 Apr 1;163(7):670-5. (PMID: 16410346) J Allergy Clin Immunol. 2012 Aug;130(2):473-80.e1. (PMID: 22846751) Allergy. 2007 Jul;62(7):758-65. (PMID: 17573723) Pediatr Clin North Am. 2011 Apr;58(2):427-43, xi. (PMID: 21453811) J Allergy Clin Immunol. 2010 Feb;125(2 Suppl 2):S161-81. (PMID: 20176258) Arch Med Sci. 2014 Dec 22;10(6):1135-41. (PMID: 25624850) J Allergy Clin Immunol. 2012 Dec;130(6):1260-74. (PMID: 23195525) J Allergy Clin Immunol. 1994 Jun;93(6):1047-59. (PMID: 8006309) J Allergy Clin Immunol. 2008 May;121(5):1219-24. (PMID: 18243289) J Allergy Clin Immunol. 2009 Jun;123(6 Suppl):S365-83. (PMID: 19500710) World Allergy Organ J. 2011 Feb;4(2):13-37. (PMID: 23268454) J Allergy Clin Immunol. 2007 Jul;120(1 Suppl):S2-24. (PMID: 17602945) J Allergy Clin Immunol Pract. 2013 Jul-Aug;1(4):354-60. (PMID: 24013255) |
فهرسة مساهمة: | Keywords: anaphylaxis; children; egg allergy; oral food challenge; ovalbumin; ovomucoid |
تواريخ الأحداث: | Date Created: 20180131 Latest Revision: 20220311 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC5778411 |
DOI: | 10.5114/aoms.2016.58796 |
PMID: | 29379543 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1734-1922 |
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DOI: | 10.5114/aoms.2016.58796 |