دورية أكاديمية
Usefulness of molecular diagnosis in egg allergic children.
| العنوان: | Usefulness of molecular diagnosis in egg allergic children. |
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| المؤلفون: | Petrosino MI; Department of Pediatrics, University of Chieti, Chieti, Italy., Scaparrotta A; Department of Pediatrics, University of Chieti, Chieti, Italy., Marcovecchio ML; Department of Pediatrics, University of Chieti, Chieti, Italy., Panichi D; Department of Pediatrics, University of Chieti, Chieti, Italy., Rapino D; Department of Pediatrics, University of Chieti, Chieti, Italy., Attanasi M; Department of Pediatrics, University of Chieti, Chieti, Italy., Filippo PD; Department of Pediatrics, University of Chieti, Chieti, Italy., Pillo SD; Department of Pediatrics, University of Chieti, Chieti, Italy., Chiarelli F; Department of Pediatrics, University of Chieti, Chieti, Italy. |
| المصدر: | Archives of medical science : AMS [Arch Med Sci] 2018 Jan; Vol. 14 (1), pp. 132-137. Date of Electronic Publication: 2016 Mar 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Termedia Pub. House Country of Publication: Poland NLM ID: 101258257 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1734-1922 (Print) Linking ISSN: 17341922 NLM ISO Abbreviation: Arch Med Sci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: [Poznań, Poland] : Termedia Pub. House, [2005]- |
| مستخلص: | Introduction: Egg allergy is one of the most common food allergies in children. Egg white, including ovomucoid (OVM or Gal d 1) and ovalbumin (OVA or Gal d 2), is the major source of allergens. The aim of this study was to assess the role of Gal d 1 and Gal d 2 in predicting the risk of anaphylaxis caused by eggs in children, and to compare this new diagnostic tool with established methods of allergen-specific IgE detection. Material and Methods: One hundred and forty-eight children were divided into 2 groups according to a positive (group A, 33 children) or negative (group B, 115 children) history of anaphylaxis after ingestion/contact with eggs. All patients underwent an allergological evaluation by measurements of specific IgE against egg white: Gal d 1 and Gal d 2. Results: Higher levels of Gal d 1, Gal d 2 and IgE against egg white were detected in group A compared to group B ( p < 0.001). Although the area under the curve was similar for Gal d 1 and Gal d 2, egg white specific IgE showed a better sensitivity (85%) for a cut-off value ≥ 0.975 kUA/l, while Gal d 1 and Gal d 2 demonstrated a better specificity (90% and 80%, respectively) for cut-off values ≥ 1.460 kUA/l and ≥ 2.310 kUA/l, respectively. Conclusions: Egg white specific IgE showed a similar ability as Gal d 1 and Gal d 2 in differentiating children at risk for egg anaphylaxis, although Gal d 1 and Gal d 2 showed a better specificity. |
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| فهرسة مساهمة: | Keywords: anaphylaxis; children; egg allergy; oral food challenge; ovalbumin; ovomucoid |
| تواريخ الأحداث: | Date Created: 20180131 Latest Revision: 20220311 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC5778411 |
| DOI: | 10.5114/aoms.2016.58796 |
| PMID: | 29379543 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1734-1922 |
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| DOI: | 10.5114/aoms.2016.58796 |