دورية أكاديمية
Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model.
| العنوان: | Variations in diet cause alterations in microbiota and metabolites that follow changes in disease severity in a multiple sclerosis model. |
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| المؤلفون: | Libbey JE; 1 Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA., Sanchez JM; 1 Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA., Doty DJ; 1 Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA., Sim JT; 1 Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA., Cusick MF; 1 Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.; 4 Baylor College of Medicine, Division of Abdominal Transplantation, Neurosensory Center, Houston, TX 77030, USA., Cox JE; 2 Department of Biochemistry and Metabolomics Core, University of Utah, 15 North Medical Drive East, A306 EEJMRB, Salt Lake City, UT 84112, USA., Fischer KF; 1 Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA.; 3 uBiota LLC, 825 N 300 W STE: NE-200, Salt Lake City, UT 84103, USA., Round JL; 1 Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA., Fujinami RS; 1 Department of Pathology, University of Utah School of Medicine, 15 North Medical Drive East, 2600 EEJMRB, Salt Lake City, UT 84112, USA. |
| المصدر: | Beneficial microbes [Benef Microbes] 2018 Apr 25; Vol. 9 (3), pp. 495-513. Date of Electronic Publication: 2018 Jan 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wageningen Academic Publishers Country of Publication: Netherlands NLM ID: 101507616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1876-2891 (Electronic) Linking ISSN: 18762883 NLM ISO Abbreviation: Benef Microbes Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Wageningen : Wageningen Academic Publishers |
| مواضيع طبية MeSH: | Gastrointestinal Microbiome* , Metabolome* , Severity of Illness Index*, Diet Therapy/*methods , Multiple Sclerosis/*pathology , Multiple Sclerosis/*therapy, Animals ; Body Weight ; Citric Acid Cycle ; Disease Models, Animal ; Feces/chemistry ; Feces/microbiology ; Glycolysis ; Lacticaseibacillus paracasei/isolation & purification ; Mice ; Serum/chemistry |
| مستخلص: | Multiple sclerosis (MS) is a metabolically demanding disease involving immune-mediated destruction of myelin in the central nervous system. We previously demonstrated a significant alteration in disease course in the experimental autoimmune encephalomyelitis (EAE) preclinical model of MS due to diet. Based on the established crosstalk between metabolism and gut microbiota, we took an unbiased sampling of microbiota, in the stool, and metabolites, in the serum and stool, from mice (Mus musculus) on the two different diets, the Teklad global soy protein-free extruded rodent diet (irradiated diet) and the Teklad sterilisable rodent diet (autoclaved diet). Within the microbiota, the genus Lactobacillus was found to be inversely correlated with EAE severity. Therapeutic treatment with Lactobacillus paracasei resulted in a significant reduction in the incidence of disease, clinical scores and the amount of weight loss in EAE mice. Within the metabolites, we identified shifts in glycolysis and the tricarboxylic acid cycle that may explain the differences in disease severity between the different diets in EAE. This work begins to elucidate the relationship between diet, microbiota and metabolism in the EAE preclinical model of MS and identifies targets for further study with the goal to more specifically probe the complex metabolic interaction at play in EAE that may have translational relevance to MS patients. |
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| معلومات مُعتمدة: | R01 NS082102 United States NS NINDS NIH HHS; S10 RR020883 United States RR NCRR NIH HHS; T32 AI055434 United States AI NIAID NIH HHS |
| فهرسة مساهمة: | Keywords: experimental autoimmune encephalomyelitis; metabolomics; microbiome; myelin oligodendrocyte glycoprotein |
| تواريخ الأحداث: | Date Created: 20180131 Date Completed: 20180918 Latest Revision: 20240620 |
| رمز التحديث: | 20240620 |
| مُعرف محوري في PubMed: | PMC5918152 |
| DOI: | 10.3920/BM2017.0116 |
| PMID: | 29380645 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1876-2891 |
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| DOI: | 10.3920/BM2017.0116 |