دورية أكاديمية
Tubulins in C. elegans.
| العنوان: | Tubulins in C. elegans. |
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| المؤلفون: | Hurd DD; Biology Department, St. John Fisher College, Rochester, NY 14618 USA. |
| المصدر: | WormBook : the online review of C. elegans biology [WormBook] 2018 Aug 04; Vol. 2018, pp. 1-32. Date of Electronic Publication: 2018 Aug 04. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Country of Publication: United States NLM ID: 101303985 Publication Model: Electronic Cited Medium: Internet ISSN: 1551-8507 (Electronic) Linking ISSN: 15518507 NLM ISO Abbreviation: WormBook Subsets: MEDLINE |
| مواضيع طبية MeSH: | Caenorhabditis elegans/*metabolism , Caenorhabditis elegans Proteins/*metabolism , Tubulin/*metabolism, Animals ; Microtubules |
| مستخلص: | The C. elegans tubulin family is composed of nine α-, six β-, and one γ-tubulin. Tubulins are highly conserved, functioning as α-β heterodimers that assemble into microtubules. These cylindrical and ubiquitous components of the cytoskeleton are critical for nearly all cellular and developmental processes. C. elegans has provided a model for the study of microtubules in multiple settings including separation of chromosomes, cellular polarity, and neuronal sensation. Tubulins and microtubules interact with a long list of other cellular proteins that regulate tubulin homeostasis, modify microtubule dynamics, and control incorporation into or disassociation of higher-order cellular structures such as spindles or ciliary axonemes. A collection of enzymes modifies tubulins, often at the variable carboxyl-terminal tail, adding another layer of regulation to microtubule structure and function. Genetic and cytological studies in C. elegans have revealed roles for tubulin and its associated proteins in numerous contexts from embryogenesis to adult behavior. |
| المشرفين على المادة: | 0 (Caenorhabditis elegans Proteins) 0 (Tubulin) |
| تواريخ الأحداث: | Date Created: 20180131 Date Completed: 20181217 Latest Revision: 20190212 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC6369417 |
| DOI: | 10.1895/wormbook.1.182.1 |
| PMID: | 29381886 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1551-8507 |
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| DOI: | 10.1895/wormbook.1.182.1 |