دورية أكاديمية
Relationship between Proinflammatory Cytokines/Chemokines and Adipokines in Serum of Young Adults with Obesity.
| العنوان: | Relationship between Proinflammatory Cytokines/Chemokines and Adipokines in Serum of Young Adults with Obesity. |
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| المؤلفون: | Borges MD; Laboratory of Scientific Writing, Department of Morphology and Physiology, School of Medicine of ABC, Santo Andre, SP, Brazil.; Institute of Biological and Health Science - Federal University of Mato Grosso - Barra do Garcas - MT, Brazil., Franca EL; Institute of Biological and Health Science - Federal University of Mato Grosso - Barra do Garcas - MT, Brazil., Fujimori M; Institute of Biological and Health Science - Federal University of Mato Grosso - Barra do Garcas - MT, Brazil., Silva SMC; Institute of Biological and Health Science - Federal University of Mato Grosso - Barra do Garcas - MT, Brazil., de Marchi PGF; Institute of Biological and Health Science - Federal University of Mato Grosso - Barra do Garcas - MT, Brazil., Deluque AL; Institute of Biological and Health Science - Federal University of Mato Grosso - Barra do Garcas - MT, Brazil., Honorio-Franca AC; Institute of Biological and Health Science - Federal University of Mato Grosso - Barra do Garcas - MT, Brazil., de Abreu LC; Laboratory of Scientific Writing, Department of Morphology and Physiology, School of Medicine of ABC, Santo Andre, SP, Brazil. |
| المصدر: | Endocrine, metabolic & immune disorders drug targets [Endocr Metab Immune Disord Drug Targets] 2018; Vol. 18 (3), pp. 260-267. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101269157 Publication Model: Print Cited Medium: Internet ISSN: 2212-3873 (Electronic) Linking ISSN: 18715303 NLM ISO Abbreviation: Endocr Metab Immune Disord Drug Targets Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Publishers, c2006- |
| مواضيع طبية MeSH: | Adipokines/*blood , Chemokines/*blood , Cytokines/*blood , Obesity/*blood , Obesity/*diagnosis, Adult ; Biomarkers/blood ; Female ; Humans ; Inflammation Mediators/blood ; Male ; Middle Aged ; Waist Circumference/physiology ; Young Adult |
| مستخلص: | Background and Objective: The adipose tissue has been recognized as an important endocrine organ, which is metabolically active and expresses and secretes various inflammatory cytokines. Inflammation is involved in obesity-related complications. As such, the present study investigated the correlation between biochemical parameters, serum proinflammatory cytokines and adipokines in individuals with obesity. Methods: Based on the body mass index (BMI), 30 subjects were divided into 3 groups: eutrophic (GC, n = 10), overweight (GOW, n = 10) and obese (GOB, n = 10). Serum glucose, cholesterol (total-C, HDLC and LDL-C), triglycerides, total proteins, uric acid and insulin were determined, as well as cytokines IL-8, TNF-α, IL-1β, and IL-6, leptin and adiponectin. Results: GOB showed the highest glucose, total and LDL-C, triglycerides, uric acid, insulin, leptin, IL- 8, IL-1β, IL-6, TNF-α and lowest adiponectin levels. In general, adiponectin exhibited an inverse correlation with BMI, abdominal circumference, LDL-C, IL-6, TNF-α, leptin and leptin-adiponectin ratio (LAR) and a positive correlation with HDL-C. Leptin was positively correlated with BMI, abdominal circumference, insulin, IL-6, TNF-α and LAR and negatively correlated with HDL-C and adiponectin. The LAR was positively correlated with BMI, waist circumference, insulin, TNF-α and negatively associated with HDL-C. Conclusion: The results confirm that obesity changes the lipid and glycemic profiles of individuals, increases the proinflammatory adipokine levels and reduces those of anti-inflammatory adipokines, promoting a state of chronic inflammation. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.) |
| فهرسة مساهمة: | Keywords: Obesity; adipokine; cytokine; dyslipidemia; inflammation; serum. |
| المشرفين على المادة: | 0 (Adipokines) 0 (Biomarkers) 0 (Chemokines) 0 (Cytokines) 0 (Inflammation Mediators) |
| تواريخ الأحداث: | Date Created: 20180201 Date Completed: 20180924 Latest Revision: 20180924 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2174/1871530318666180131094733 |
| PMID: | 29384066 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2212-3873 |
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| DOI: | 10.2174/1871530318666180131094733 |