دورية أكاديمية
Protective effects of fermented honeybush (Cyclopia intermedia) extract (HU-018) against skin aging: a randomized, double-blinded, placebo-controlled study.
| العنوان: | Protective effects of fermented honeybush (Cyclopia intermedia) extract (HU-018) against skin aging: a randomized, double-blinded, placebo-controlled study. |
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| المؤلفون: | Choi SY; a Department of Dermatology, Seoul Paik Hospital , Inje University College of Medicine , Seoul , Korea., Hong JY; b Department of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea., Ko EJ; c Department of Dermatology, Myongji Hospital , Seonam University College of Medicine , Goyang , Korea., Kim BJ; b Department of Dermatology , Chung-Ang University College of Medicine , Seoul , Korea., Hong SW; d Department of Clinical Research & Medical information , Huons Co., Ltd ., Gyeonggi-do , Korea., Lim MH; d Department of Clinical Research & Medical information , Huons Co., Ltd ., Gyeonggi-do , Korea., Yeon SH; e Botanical Drug Research Team , Huons Co., Ltd ., Gyeonggi-do , Korea., Son RH; e Botanical Drug Research Team , Huons Co., Ltd ., Gyeonggi-do , Korea. |
| المصدر: | Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology [J Cosmet Laser Ther] 2018 Oct; Vol. 20 (5), pp. 313-318. Date of Electronic Publication: 2018 Feb 01. |
| نوع المنشور: | Journal Article; Randomized Controlled Trial |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 101136419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4180 (Electronic) Linking ISSN: 14764172 NLM ISO Abbreviation: J Cosmet Laser Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: London : Martin Dunitz, c2001- |
| مواضيع طبية MeSH: | Cyclopia Plant* , Phytotherapy*/adverse effects, Antioxidants/*therapeutic use , Plant Extracts/*therapeutic use , Skin Aging/*drug effects , Skin Physiological Phenomena/*drug effects, Adult ; Antioxidants/administration & dosage ; Antioxidants/adverse effects ; Double-Blind Method ; Elasticity/drug effects ; Eye ; Female ; Fermentation ; Humans ; Middle Aged ; Plant Extracts/administration & dosage ; Plant Extracts/adverse effects ; Rejuvenation ; Water Loss, Insensible/drug effects |
| مستخلص: | Background: Oxidative stress and photodamage resulting from ultraviolet radiation exposure play key roles in skin aging. Fermented Cyclopia intermedia, which is used to brew honeybush tea, exerts antioxidant and anti-wrinkle effects by inhibiting reactive oxygen species production and downregulating matrix metalloproteinase activity. Objectives: This randomized, double-blinded, placebo-controlled study aimed to evaluate the efficacy and safety of fermented honeybush (Cyclopia intermedia) extract (HU-018) for skin rejuvenation. Methods: 120 Korean subjects with crow's feet wrinkles were randomized to receive either low-dose extract (400 mg/day), high-dose extract (800 mg/day), or placebo (negative control, only dextran) for 12 weeks. Wrinkles were evaluated using JANUS ® and PRIMO pico ® . Skin elasticity, hydration and transepidermal water loss were measured. Results: Global skin wrinkle grade was significantly improved in both low-dose and high-dose groups compared to placebo group, as well as for skin hydration and elasticity. Both the low- and high-dose groups showed significantly decreased TEWL compared to the placebo group. There were no adverse effects during the entire study period. Conclusion: Our data indicate that HU-018 is effective for improving skin wrinkles, elasticity, and hydration. Therefore, daily supplementation with fermented honeybush could be helpful for protecting against skin aging. |
| فهرسة مساهمة: | Keywords: Fermented Cyclopia intermedia; honeybush; skin aging |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20180202 Date Completed: 20190313 Latest Revision: 20190313 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/14764172.2017.1418512 |
| PMID: | 29388846 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1476-4180 |
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| DOI: | 10.1080/14764172.2017.1418512 |