دورية أكاديمية
أعرض في EDS

Fitting NTCP models to bladder doses and acute urinary symptoms during post-prostatectomy radiotherapy.

التفاصيل البيبلوغرافية
العنوان: Fitting NTCP models to bladder doses and acute urinary symptoms during post-prostatectomy radiotherapy.
المؤلفون: Mavroidis P; Department of Radiation Oncology, University of North Carolina, 101 Manning Dr, Chapel Hill, NC, 27599-7512, USA. panayiotis_mavroidis@med.unc.edu., Pearlstein KA; Department of Radiation Oncology, University of North Carolina, 101 Manning Dr, Chapel Hill, NC, 27599-7512, USA., Dooley J; Department of Radiation Oncology, University of North Carolina, 101 Manning Dr, Chapel Hill, NC, 27599-7512, USA., Sun J; Department of Radiation Oncology, University of North Carolina, 101 Manning Dr, Chapel Hill, NC, 27599-7512, USA., Saripalli S; Department of Radiation Oncology, University of North Carolina, 101 Manning Dr, Chapel Hill, NC, 27599-7512, USA., Das SK; Department of Radiation Oncology, University of North Carolina, 101 Manning Dr, Chapel Hill, NC, 27599-7512, USA., Wang AZ; Department of Radiation Oncology, University of North Carolina, 101 Manning Dr, Chapel Hill, NC, 27599-7512, USA., Chen RC; Department of Radiation Oncology, University of North Carolina, 101 Manning Dr, Chapel Hill, NC, 27599-7512, USA.
المصدر: Radiation oncology (London, England) [Radiat Oncol] 2018 Feb 02; Vol. 13 (1), pp. 17. Date of Electronic Publication: 2018 Feb 02.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101265111 Publication Model: Electronic Cited Medium: Internet ISSN: 1748-717X (Electronic) Linking ISSN: 1748717X NLM ISO Abbreviation: Radiat Oncol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2006-
مواضيع طبية MeSH: Prostatic Neoplasms/*radiotherapy , Radiation Injuries/*etiology , Radiotherapy, Intensity-Modulated/*adverse effects , Radiotherapy, Intensity-Modulated/*methods , Urination Disorders/*etiology, Humans ; Male ; Organs at Risk ; Prostatectomy ; Prostatic Neoplasms/surgery ; Radiobiology/methods ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Retrospective Studies ; Urinary Bladder/radiation effects ; Urination Disorders/epidemiology
مستخلص: Background: To estimate the radiobiological parameters of three popular normal tissue complication probability (NTCP) models, which describe the dose-response relations of bladder regarding different acute urinary symptoms during post-prostatectomy radiotherapy (RT). To evaluate the goodness-of-fit and the correlation of those models with those symptoms.
Methods: Ninety-three consecutive patients treated from 2010 to 2015 with post-prostatectomy image-guided intensity modulated radiotherapy (IMRT) were included in this study. Patient-reported urinary symptoms were collected pre-RT and weekly during treatment using the validated Prostate Cancer Symptom Indices (PCSI). The assessed symptoms were flow, dysuria, urgency, incontinence, frequency and nocturia using a Likert scale of 1 to 4 or 5. For this analysis, an increase by ≥2 levels in a symptom at any time during treatment compared to baseline was considered clinically significant. The dose volume histograms of the bladder were calculated. The Lyman-Kutcher-Burman (LKB), Relative Seriality (RS) and Logit NTCP models were used to fit the clinical data. The fitting of the different models was assessed through the area under the receiver operating characteristic curve (AUC), Akaike information criterion (AIC) and Odds Ratio methods.
Results: For the symptoms of urinary urgency, leakage, frequency and nocturia, the derived LKB model parameters were: 1) D 50  = 64.2Gy, m = 0.50, n = 1.0; 2) D 50  = 95.0Gy, m = 0.45, n = 0.50; 3) D 50  = 83.1Gy, m = 0.56, n = 1.00; and 4) D 50  = 85.4Gy, m = 0.60, n = 1.00, respectively. The AUC values for those symptoms were 0.66, 0.58, 0.64 and 0.64, respectively. The differences in AIC between the different models were less than 2 and ranged within 0.1 and 1.3.
Conclusions: Different dose metrics were correlated with the symptoms of urgency, incontinence, frequency and nocturia. The symptoms of urinary flow and dysuria were poorly associated with dose. The values of the parameters of three NTCP models were determined for bladder regarding four acute urinary symptoms. All the models could fit the clinical data equally well. The NTCP predictions of urgency showed the best correlation with the patient reported outcomes.
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فهرسة مساهمة: Keywords: Acute urinary symptoms; LKB; Logit; NTCP; Post-prostatectomy radiotherapy; Radiobiological parameters; Relative seriality
تواريخ الأحداث: Date Created: 20180204 Date Completed: 20180821 Latest Revision: 20231112
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5797360
DOI: 10.1186/s13014-018-0961-x
PMID: 29394931
قاعدة البيانات: MEDLINE
الوصف
تدمد:1748-717X
DOI:10.1186/s13014-018-0961-x