دورية أكاديمية
ATP-dependent Ca2+ transport and Na+/Ca2+ exchange system in renal basolateral plasmamembranes of spontaneously hypertensive rats.
| العنوان: | ATP-dependent Ca2+ transport and Na+/Ca2+ exchange system in renal basolateral plasmamembranes of spontaneously hypertensive rats. |
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| المؤلفون: | Bindels RJ, Geertsen JA, van Os CH |
| المصدر: | Clinical and experimental hypertension. Part A, Theory and practice [Clin Exp Hypertens A] 1985-1986; Vol. 7 (12), pp. 1719-31. |
| نوع المنشور: | Comparative Study; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Dekker Country of Publication: United States NLM ID: 8207790 Publication Model: Print Cited Medium: Print ISSN: 0730-0077 (Print) Linking ISSN: 07300077 NLM ISO Abbreviation: Clin Exp Hypertens A Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, N.Y. : Dekker, c1982-c1992. |
| مواضيع طبية MeSH: | Adenosine Triphosphatases/*metabolism , Calcium-Transporting ATPases/*metabolism , Hypertension/*enzymology , Kidney Cortex/*enzymology, Animals ; Calcium/metabolism ; Calcium Radioisotopes ; Cell Membrane/enzymology ; Kinetics ; Male ; Models, Biological ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY |
| مستخلص: | A common abnormality of cellular Ca2+ handling in most tissues of spontaneously hypertensive rats (SHR) has been suggested. Therefore we investigated the ATP-dependent Ca2+ transport and Na+/Ca2+ exchange system in basolateral membrane vesicles (BLMV) of renal cortices from SHR and normotensive Wistar-Kyoto rats (WKY) at 12 and 20 weeks of age. In WKY the maximal transport rate of the ATP-dependent Ca2+ transport was 5.7 nmol/min/mg prot with an affinity for Ca2+ of 0.14 microM. These values were not significantly different in SHR at both ages studied. High concentrations of Na+ inhibited ATP-dependent Ca2+ uptake by 40% in BLMV of SHR and WKY. Low concentrations of Na+ stimulated ATP-dependent Ca2+ transport 20% in both rats. These findings suggest equal Na+/Ca2+ exchange activity in WKY and SHR. The present study failed to show a significant change in ATP-dependent Ca2+ transport and Na+/Ca2+ exchange activity in renal BLMV in SHR, suggesting that the Ca2+ homeostasis of the cortical cells is normal in SHR as far as the plasmamembrane is concerned. |
| المشرفين على المادة: | 0 (Calcium Radioisotopes) EC 3.6.1.- (Adenosine Triphosphatases) EC 3.6.1.- (sodium calcium ATPase) EC 7.2.2.10 (Calcium-Transporting ATPases) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 19850101 Date Completed: 19860707 Latest Revision: 20191210 |
| رمز التحديث: | 20240513 |
| DOI: | 10.3109/10641968509073621 |
| PMID: | 2940035 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 0730-0077 |
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| DOI: | 10.3109/10641968509073621 |