دورية أكاديمية
Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study.
| العنوان: | Cord Blood Metabolic Signatures of Birth Weight: A Population-Based Study. |
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| المؤلفون: | Robinson O; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London , St. Mary's Campus, Norfolk Place, London W2 1PG, United Kingdom., Keski-Rahkonen P; International Agency for Research on Cancer (IARC) , 150 Cours Albert Thomas, 69372 Lyon, France., Chatzi L; Department of Social Medicine, Faculty of Medicine, University of Crete , Voutes University Campus, Heraklion, Crete, GR-70013, Greece.; Department of Preventive Medicine, Keck School of Medicine, University of South California , Soto Street Building 2001 N Soto Street, Suite 201-D, Los Angeles, California 90032-3628, United States.; Department of Genetics & Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University , Universiteitssingel 40, 6229 Maastricht, The Netherlands., Kogevinas M; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL) , PRBB, C/ Doctor Aiguader, 88, 08003, Barcelona Spain.; Universitat Pompeu Fabra (UPF) , Plaça de la Mercè, 10, Barcelona 08002, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP) , PRBB, C/ Doctor Aiguader, 88, E-08003 Barcelona, Spain., Nawrot T; Centre for Environmental Sciences, Hasselt University , Campus Diepenbeek, Agoralaan building D, BE3590 Diepenbeek, Belgium.; Department of Public Health & Primary Care, Leuven University , Oude Markt 13, B-3000 Leuven, Belgium., Pizzi C; Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte , C.So, Dogliotti, 14, 10126 Turin, Italy., Plusquin M; Centre for Environmental Sciences, Hasselt University , Campus Diepenbeek, Agoralaan building D, BE3590 Diepenbeek, Belgium.; Department of Public Health & Primary Care, Leuven University , Oude Markt 13, B-3000 Leuven, Belgium., Richiardi L; Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin and CPO-Piemonte , C.So, Dogliotti, 14, 10126 Turin, Italy., Robinot N; International Agency for Research on Cancer (IARC) , 150 Cours Albert Thomas, 69372 Lyon, France., Sunyer J; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL) , PRBB, C/ Doctor Aiguader, 88, 08003, Barcelona Spain.; Universitat Pompeu Fabra (UPF) , Plaça de la Mercè, 10, Barcelona 08002, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP) , PRBB, C/ Doctor Aiguader, 88, E-08003 Barcelona, Spain., Vermeulen R; Institute for Risk Assessment Sciences, Environmental Epidemiology Division, Utrecht University , POB 80178, Utrecht NL-3508, The Netherlands., Vrijheid M; ISGlobal, Centre for Research in Environmental Epidemiology (CREAL) , PRBB, C/ Doctor Aiguader, 88, 08003, Barcelona Spain.; Universitat Pompeu Fabra (UPF) , Plaça de la Mercè, 10, Barcelona 08002, Spain.; CIBER Epidemiología y Salud Pública (CIBERESP) , PRBB, C/ Doctor Aiguader, 88, E-08003 Barcelona, Spain., Vineis P; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London , St. Mary's Campus, Norfolk Place, London W2 1PG, United Kingdom., Scalbert A; International Agency for Research on Cancer (IARC) , 150 Cours Albert Thomas, 69372 Lyon, France., Chadeau-Hyam M; MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London , St. Mary's Campus, Norfolk Place, London W2 1PG, United Kingdom. |
| المصدر: | Journal of proteome research [J Proteome Res] 2018 Mar 02; Vol. 17 (3), pp. 1235-1247. Date of Electronic Publication: 2018 Feb 09. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101128775 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-3907 (Electronic) Linking ISSN: 15353893 NLM ISO Abbreviation: J Proteome Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society, c2002- |
| مواضيع طبية MeSH: | Metabolome*, Birth Weight/*physiology , Fetal Blood/*chemistry , Fetal Development/*physiology, Carnitine/analogs & derivatives ; Carnitine/blood ; Chromatography, High Pressure Liquid ; Cohort Studies ; Docosahexaenoic Acids/blood ; Environmental Exposure/analysis ; Europe ; Female ; Fetus ; Humans ; Indoles/blood ; Infant, Newborn ; Male ; Mass Spectrometry/methods ; Particulate Matter/analysis ; Phosphatidylcholines/blood ; Pregnancy ; Progesterone/blood ; Prostaglandins/blood ; Reference Standards ; Tryptophan/blood ; Vitamin A/blood |
| مستخلص: | Birth weight is an important indicator of maternal and fetal health and a predictor of health in later life. However, the determinants of variance in birth weight are still poorly understood. We aimed to identify the biological pathways, which may be perturbed by environmental exposures, that are important in determining birth weight. We applied untargeted mass-spectrometry-based metabolomics to 481 cord blood samples collected at delivery in four birth cohorts from across Europe: ENVIRONAGE (Belgium), INMA (Spain), Piccolipiu (Italy), and Rhea (Greece). We performed a metabolome-wide association scan for birth weight on over 4000 metabolic features, controlling the false discovery rate at 5%. Annotation of compounds was conducted through reference to authentic standards. We identified 68 metabolites significantly associated with birth weight, including vitamin A, progesterone, docosahexaenoic acid, indolelactic acid, and multiple acylcarnitines and phosphatidylcholines. We observed enrichment (p < 0.05) of the tryptophan metabolism, prostaglandin formation, C21-steroid hormone signaling, carnitine shuttle, and glycerophospholipid metabolism pathways. Vitamin A was associated with both maternal smoking and birth weight, suggesting a mediation pathway. Our findings shed new light on the pathways central to fetal growth and will have implications for antenatal and perinatal care and potentially for health in later life. |
| معلومات مُعتمدة: | 001 International WHO_ World Health Organization; 22184 United Kingdom CRUK_ Cancer Research UK |
| فهرسة مساهمة: | Keywords: birth weight; cord blood; fetal growth; metabolism; metabolomics; pathway perturbation |
| المشرفين على المادة: | 0 (Indoles) 0 (Particulate Matter) 0 (Phosphatidylcholines) 0 (Prostaglandins) 0 (acylcarnitine) 11103-57-4 (Vitamin A) 25167-62-8 (Docosahexaenoic Acids) 4G7DS2Q64Y (Progesterone) 5SW11R7M7M (indole-3-lactic acid) 8DUH1N11BX (Tryptophan) S7UI8SM58A (Carnitine) |
| تواريخ الأحداث: | Date Created: 20180206 Date Completed: 20180917 Latest Revision: 20240324 |
| رمز التحديث: | 20240324 |
| DOI: | 10.1021/acs.jproteome.7b00846 |
| PMID: | 29401400 |
| قاعدة البيانات: | MEDLINE |
Find this issue from the American Chemical Society | تدمد: | 1535-3907 |
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| DOI: | 10.1021/acs.jproteome.7b00846 |