دورية أكاديمية
Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs.
| العنوان: | Zika Virus Infection in Syrian Golden Hamsters and Strain 13 Guinea Pigs. |
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| المؤلفون: | Miller LJ; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Veterinary Medicine Division, Fort Detrick, Maryland., Nasar F; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland., Schellhase CW; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Pathology Division, Fort Detrick, Maryland., Norris SL; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Biostatistics Division, Fort Detrick, Maryland., Kimmel AE; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland., Valdez SM; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland., Wollen-Roberts SE; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland., Shamblin JD; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland., Sprague TR; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland., Lugo-Roman LA; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Veterinary Medicine Division, Fort Detrick, Maryland., Jarman RG; Walter Reed Army Institute of Research, Virology Division, Silver Spring, Maryland., Yoon IK; International Vaccine Institute (IVI), Seoul, Republic of Korea., Alera MT; Philippines-AFRIMS Virology Research Unit (PARVU), Cebu City, Philippines., Bavari S; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland., Pitt MLM; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland., Haddow AD; United States Army Medical Research Institute of Infectious Diseases (USAMRIID), Virology Division, Fort Detrick, Maryland. |
| المصدر: | The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2018 Mar; Vol. 98 (3), pp. 864-867. Date of Electronic Publication: 2018 Feb 01. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Society of Tropical Medicine and Hygiene Country of Publication: United States NLM ID: 0370507 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-1645 (Electronic) Linking ISSN: 00029637 NLM ISO Abbreviation: Am J Trop Med Hyg Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Northbrook, IL : American Society of Tropical Medicine and Hygiene Original Publication: Baltimore. |
| مواضيع طبية MeSH: | Disease Resistance*, Antibodies, Neutralizing/*biosynthesis , Antibodies, Viral/*biosynthesis , Viremia/*virology , Zika Virus/*immunology , Zika Virus Infection/*virology, Animals ; Disease Models, Animal ; Female ; Guinea Pigs ; Host Specificity ; Injections, Intraperitoneal ; Injections, Subcutaneous ; Mesocricetus ; Viremia/immunology ; Zika Virus/growth & development ; Zika Virus Infection/immunology |
| مستخلص: | To evaluate potential immunocompetent small animal models of Zika virus (ZIKV) infection, we inoculated Syrian golden hamsters (subcutaneously or intraperitoneally) and strain 13 guinea pigs (intraperitoneally) with Senegalese ZIKV strain ArD 41525 or Philippines ZIKV strain CPC-0740. We did not detect viremia in hamsters inoculated subcutaneously with either virus strain, although some hamsters developed virus neutralizing antibodies. However, we detected statistically significant higher viremias ( P = 0.0285) and a higher median neutralization titer ( P = 0.0163) in hamsters inoculated intraperitoneally with strain ArD 41525 compared with strain CPC-0740. Furthermore, some hamsters inoculated with strain ArD 41525 displayed mild signs of disease. By contrast, strain 13 guinea pigs inoculated intraperitoneally with either strain did not have detectable viremias and less than half developed virus neutralizing antibodies. Our results support the use of the Syrian golden hamster intraperitoneal model to explore phenotypic variation between ZIKV strains. |
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| المشرفين على المادة: | 0 (Antibodies, Neutralizing) 0 (Antibodies, Viral) |
| تواريخ الأحداث: | Date Created: 20180207 Date Completed: 20181211 Latest Revision: 20190301 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5930900 |
| DOI: | 10.4269/ajtmh.17-0686 |
| PMID: | 29405107 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1476-1645 |
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| DOI: | 10.4269/ajtmh.17-0686 |