دورية أكاديمية
أعرض في EDS

KIR2DS1, 2DS5, 3DS1 and KIR2DL5 are associated with the risk of head and neck squamous cell carcinoma in Iranians.

التفاصيل البيبلوغرافية
العنوان: KIR2DS1, 2DS5, 3DS1 and KIR2DL5 are associated with the risk of head and neck squamous cell carcinoma in Iranians.
المؤلفون: Barani S; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Khademi B; Otolaryngology Research Center, Department of Otolaryngology, Shiraz University of Medical Sciences, Iran., Ashouri E; Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran., Ghaderi A; Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran; Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: ghaderia@sums.ac.ir.
المصدر: Human immunology [Hum Immunol] 2018 Apr; Vol. 79 (4), pp. 218-223. Date of Electronic Publication: 2018 Feb 09.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Country of Publication: United States NLM ID: 8010936 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1166 (Electronic) Linking ISSN: 01988859 NLM ISO Abbreviation: Hum Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [New York] Elsevier/North-Holland.
مواضيع طبية MeSH: Carcinoma, Squamous Cell/*genetics , Head and Neck Neoplasms/*genetics , Receptors, KIR/*genetics , Receptors, KIR2DL5/*genetics , Receptors, KIR3DS1/*genetics, Aged ; Base Sequence/genetics ; Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/immunology ; Case-Control Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Head and Neck Neoplasms/epidemiology ; Head and Neck Neoplasms/immunology ; Humans ; Iran/epidemiology ; Killer Cells, Natural/immunology ; Male ; Middle Aged ; Polymerase Chain Reaction ; Receptors, KIR/immunology ; Receptors, KIR2DL5/immunology ; Receptors, KIR3DS1/immunology ; Sequence Deletion ; Squamous Cell Carcinoma of Head and Neck ; Tumor Microenvironment/genetics ; Tumor Microenvironment/immunology
مستخلص: Background: Activating and inhibitory KIR receptors (aKIR, iKIR) control the development and function of NK cells whose function alterations adjust the tumor microenvironment immunity. This research was conducted to determine the KIRs gene impact on genetic predisposition to Head and Neck Squamous Cell Carcinoma (HNSCC) in Iranians.
Methods: KIR genotyping using sequence-specific primers-polymerase chain reaction (SSP-PCR) method was performed to identify the presence of all 16 KIR genes in 285 HNSCC patients, including laryngeal, oral cavity and pharyngeal SCC and 273 controls (CNs).
Results: Comparison of KIRs gene frequency between HNSCC and CNs revealed a highly significant increase in KIR2DL5, 2DS1, 2DS5, 3DS1 and CxT4 genotype and a decrease in KIR2DS4 deleted variant and AA genotype carriers. A significant increase was noted in individuals withhigher iKIRs than aKIRs in HNSCC compared with CNs. Individuals with ≥4 iKIR and those with ≥5 aKIRs were significantly more common in HNSCC than CNs. 68distinct KIR genotypes were identified in 558 individuals.
Conclusion: Our findings determined the detrimental impact of KIR2DS1, 2DS5, 3DS1, 2DL5 and CxT4 genotype as well as the protective impact of KIR2DS4del and AA genotype on genetic predisposition to HNSCC in Iranians.
(Copyright © 2018 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.)
فهرسة مساهمة: Keywords: Head and neck squamous cell carcinoma (HNSCC); Killer immunoglobulin like receptors (KIRs); NK cells; SSP-PCR
المشرفين على المادة: 0 (KIR2DS1 protein, human)
0 (KIR2DS4 protein, human)
0 (KIR2DS5 protein, human)
0 (KIR3DS1 protein, human)
0 (Receptors, KIR)
0 (Receptors, KIR2DL5)
0 (Receptors, KIR3DS1)
تواريخ الأحداث: Date Created: 20180207 Date Completed: 20181105 Latest Revision: 20190221
رمز التحديث: 20240628
DOI: 10.1016/j.humimm.2018.01.012
PMID: 29408295
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-1166
DOI:10.1016/j.humimm.2018.01.012