دورية أكاديمية
Exploring Molecular Speciation and Crystallization Mechanism of Amorphous 2-Phenylamino Nicotinic Acid.
| العنوان: | Exploring Molecular Speciation and Crystallization Mechanism of Amorphous 2-Phenylamino Nicotinic Acid. |
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| المؤلفون: | Kalra A; Department of Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, RHPH Building, Room 124B, 575 Stadium Mall Drive, West Lafayette, Indiana, 47907-2091, USA., Lubach JW; Genentech, Inc., South San Francisco, California, 94080, USA., Munson EJ; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY, 40508, USA., Li T; Department of Industrial & Physical Pharmacy, College of Pharmacy, Purdue University, RHPH Building, Room 124B, 575 Stadium Mall Drive, West Lafayette, Indiana, 47907-2091, USA. tonglei@purdue.edu. |
| المصدر: | Pharmaceutical research [Pharm Res] 2018 Feb 07; Vol. 35 (3), pp. 51. Date of Electronic Publication: 2018 Feb 07. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : New York, NY : Kluwer Academic/Plenum Publishers Original Publication: Stuttgart ; New York : Thieme, c1984- |
| مواضيع طبية MeSH: | Phase Transition*, Aniline Compounds/*chemistry , Niacin/*chemistry, Chemistry, Pharmaceutical ; Crystallization ; Dimerization ; Molecular Structure ; Solubility ; Spectrum Analysis |
| مستخلص: | Purpose: Molecular understanding of phase stability and transition of the amorphous state helps in formulation and manufacturing of poorly-soluble drugs. Crystallization of a model compound, 2-phenylamino nicotinic acid (2PNA), from the amorphous state was studied using solid-state analytical methods. Our previous report suggests that 2PNA molecules mainly develop intermolecular -COOH∙∙∙pyridine N (acid-pyridine) interactions in the amorphous state. In the current study, the molecular speciation is explored with regard to the phase transition from the amorphous to the crystalline state. Methods: Using spectroscopic techniques, the molecular interactions and structural evolvement during the recrystallization from the glassy state were investigated. Results: The results unveiled that the structurally heterogeneous amorphous state contains acid-pyridine aggregates - either as hydrogen-bonded neutral molecules or as zwitterions - as well as a population of carboxylic acid dimers. Phase transition from the amorphous state results in crystal structures composed of carboxylic acid dimer (acid-acid) synthon or acid-pyridine chains depending on the crystallization conditions employed. Conclusions: The study underlines the structural evolvement, as well as its impact on the metastability, of amorphous samples from local, supramolecular assemblies to long-range intermolecular ordering through crystallization. |
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| فهرسة مساهمة: | Keywords: amorphous; crystallization; intermolecular interactions; molecular species; nucleation; phase transition; solid-state NMR spectroscopy |
| المشرفين على المادة: | 0 (Aniline Compounds) 2679MF687A (Niacin) |
| تواريخ الأحداث: | Date Created: 20180209 Date Completed: 20190429 Latest Revision: 20190429 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1007/s11095-018-2346-0 |
| PMID: | 29417314 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1573-904X |
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| DOI: | 10.1007/s11095-018-2346-0 |