دورية أكاديمية
Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice.
| العنوان: | Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice. |
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| المؤلفون: | Sapouckey SA; Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts., Kassotis CD; Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri., Nagel SC; Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri., Vandenberg LN; Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts. |
| المصدر: | Endocrinology [Endocrinology] 2018 Mar 01; Vol. 159 (3), pp. 1277-1289. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions, |
| مواضيع طبية MeSH: | Endocrine Disruptors/*toxicity , Hydraulic Fracking/*methods , Mammary Glands, Animal/*growth & development , Oil and Gas Industry/*methods , Prenatal Exposure Delayed Effects/*chemically induced, Animals ; Apoptosis ; Environmental Exposure ; Female ; Gestational Age ; Immunohistochemistry ; In Situ Nick-End Labeling ; Lactation ; Mammary Glands, Animal/pathology ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Sexual Maturation |
| مستخلص: | Unconventional oil and gas (UOG) operations, which combine hydraulic fracturing (fracking) and directional drilling, involve the use of hundreds of chemicals, including many with endocrine-disrupting properties. Two previous studies examined mice exposed during early development to a 23-chemical mixture of UOG compounds (UOG-MIX) commonly used or produced in the process. Both male and female offspring exposed prenatally to one or more doses of UOG-MIX displayed alterations to endocrine organ function and serum hormone concentrations. We hypothesized that prenatal UOG-MIX exposure would similarly disrupt development of the mouse mammary gland. Female C57Bl/6 mice were exposed to ~3, ~30, ~ 300, or ~3000 μg/kg/d UOG-MIX from gestational day 11 to birth. Although no effects were observed on the mammary glands of these females before puberty, in early adulthood, females exposed to 300 or 3000 μg/kg/d UOG-MIX developed more dense mammary epithelial ducts; females exposed to 3 μg/kg/d UOG-MIX had an altered ratio of apoptosis to proliferation in the mammary epithelium. Furthermore, adult females from all UOG-MIX-treated groups developed intraductal hyperplasia that resembled terminal end buds (i.e., highly proliferative structures typically seen at puberty). These results suggest that the mammary gland is sensitive to mixtures of chemicals used in UOG production at exposure levels that are environmentally relevant. The effect of these findings on the long-term health of the mammary gland, including its lactational capacity and its risk of cancer, should be evaluated in future studies. (Copyright © 2018 Endocrine Society.) |
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| معلومات مُعتمدة: | K22 ES025811 United States ES NIEHS NIH HHS; R01 ES021394 United States ES NIEHS NIH HHS; R21 ES026395 United States ES NIEHS NIH HHS |
| المشرفين على المادة: | 0 (Endocrine Disruptors) |
| تواريخ الأحداث: | Date Created: 20180210 Date Completed: 20181105 Latest Revision: 20190301 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5809159 |
| DOI: | 10.1210/en.2017-00866 |
| PMID: | 29425295 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1945-7170 |
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| DOI: | 10.1210/en.2017-00866 |