دورية أكاديمية
Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice.
العنوان: | Prenatal Exposure to Unconventional Oil and Gas Operation Chemical Mixtures Altered Mammary Gland Development in Adult Female Mice. |
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المؤلفون: | Sapouckey SA; Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts., Kassotis CD; Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri., Nagel SC; Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, Missouri., Vandenberg LN; Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst, Massachusetts. |
المصدر: | Endocrinology [Endocrinology] 2018 Mar 01; Vol. 159 (3), pp. 1277-1289. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2017- : New York : Oxford University Press Original Publication: Los Angeles, Calif. : Association for the Study of Internal Secretions, |
مواضيع طبية MeSH: | Endocrine Disruptors/*toxicity , Hydraulic Fracking/*methods , Mammary Glands, Animal/*growth & development , Oil and Gas Industry/*methods , Prenatal Exposure Delayed Effects/*chemically induced, Animals ; Apoptosis ; Environmental Exposure ; Female ; Gestational Age ; Immunohistochemistry ; In Situ Nick-End Labeling ; Lactation ; Mammary Glands, Animal/pathology ; Mice ; Mice, Inbred C57BL ; Pregnancy ; Sexual Maturation |
مستخلص: | Unconventional oil and gas (UOG) operations, which combine hydraulic fracturing (fracking) and directional drilling, involve the use of hundreds of chemicals, including many with endocrine-disrupting properties. Two previous studies examined mice exposed during early development to a 23-chemical mixture of UOG compounds (UOG-MIX) commonly used or produced in the process. Both male and female offspring exposed prenatally to one or more doses of UOG-MIX displayed alterations to endocrine organ function and serum hormone concentrations. We hypothesized that prenatal UOG-MIX exposure would similarly disrupt development of the mouse mammary gland. Female C57Bl/6 mice were exposed to ~3, ~30, ~ 300, or ~3000 μg/kg/d UOG-MIX from gestational day 11 to birth. Although no effects were observed on the mammary glands of these females before puberty, in early adulthood, females exposed to 300 or 3000 μg/kg/d UOG-MIX developed more dense mammary epithelial ducts; females exposed to 3 μg/kg/d UOG-MIX had an altered ratio of apoptosis to proliferation in the mammary epithelium. Furthermore, adult females from all UOG-MIX-treated groups developed intraductal hyperplasia that resembled terminal end buds (i.e., highly proliferative structures typically seen at puberty). These results suggest that the mammary gland is sensitive to mixtures of chemicals used in UOG production at exposure levels that are environmentally relevant. The effect of these findings on the long-term health of the mammary gland, including its lactational capacity and its risk of cancer, should be evaluated in future studies. (Copyright © 2018 Endocrine Society.) |
References: | Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2196-201. (PMID: 16452162) Biol Reprod. 2001 Oct;65(4):1215-23. (PMID: 11566746) Reprod Toxicol. 2013 Dec;42:132-55. (PMID: 23994667) Endocrinology. 2005 Sep;146(9):4138-47. (PMID: 15919749) J Vis Exp. 2011 Jul 21;(53):null. (PMID: 21808224) Environ Sci Technol. 2014;48(15):8334-48. (PMID: 24606408) Wiley Interdiscip Rev Dev Biol. 2015 May-Jun;4(3):181-95. (PMID: 25645332) Toxicol Sci. 2001 Jun;61(2):201-10. (PMID: 11353128) J Vet Med A Physiol Pathol Clin Med. 2003 May;50(4):204-12. (PMID: 12948158) Reprod Toxicol. 2010 Sep;30(2):313-21. (PMID: 20420898) J Air Waste Manag Assoc. 2012 Jun;62(6):607-24. (PMID: 22788100) Environ Sci Technol. 2004 Dec 1;38(23 ):6343-52. (PMID: 15597891) Environ Health Perspect. 2007 Jan;115(1):80-6. (PMID: 17366824) J Natl Cancer Inst. 2001 Nov 21;93(22):1673-5. (PMID: 11717320) Reproduction. 2014 Mar 02;147(4):489-501. (PMID: 24298046) Reprod Toxicol. 2008 Nov-Dec;26(3-4):210-9. (PMID: 18938238) Environ Health Perspect. 2002 Sep;110(9):917-21. (PMID: 12204827) J Endocrinol. 2008 Jan;196(1):101-12. (PMID: 18180321) Cancer. 2007 Jun 15;109(12 Suppl):2635-66. (PMID: 17503434) Rev Environ Health. 2014;29(4):307-18. (PMID: 25478730) Exp Cell Res. 1965 Apr;38:13-32. (PMID: 14281193) Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):337-42. (PMID: 10618419) J Mammary Gland Biol Neoplasia. 2017 Jun;22(2):93-108. (PMID: 28168376) Evol Dev. 2003 Jan-Feb;5(1):67-75. (PMID: 12492412) J Exp Med. 2003 Dec 15;198(12):1899-908. (PMID: 14676301) Endocrinology. 2015 Aug;156(8):2918-33. (PMID: 26018250) J Mammary Gland Biol Neoplasia. 1997 Oct;2(4):323-34. (PMID: 10935020) Dev Biol. 1977 Dec;61(2):358-65. (PMID: 590632) Rev Environ Health. 2009 Oct-Dec;24(4):319-25. (PMID: 20384040) Endocrinology. 2016 Jul;157(7):2586-94. (PMID: 27175970) Reprod Toxicol. 2007 Apr-May;23(3):383-90. (PMID: 17123778) Endocrinology. 2012 Sep;153(9):4097-110. (PMID: 22733974) Environ Health Perspect. 2011 Aug;119(8):1053-61. (PMID: 21697028) Sci Rep. 2017 Jun 13;7(1):3373. (PMID: 28611354) Science. 2013 May 17;340(6134):1235009. (PMID: 23687049) Dev Biol. 1983 Jun;97(2):274-90. (PMID: 6852366) Reprod Toxicol. 2012 Sep;34(2):261-74. (PMID: 22659286) Reprod Toxicol. 2015 Jul;54:26-36. (PMID: 25499722) Reprod Toxicol. 2011 Feb;31(2):200-9. (PMID: 21075200) J Mammary Gland Biol Neoplasia. 2013 Jun;18(2):199-208. (PMID: 23702822) Environ Health Perspect. 2016 Mar;124(3):256-64. (PMID: 26311476) Breast Cancer Res. 2005;7(6):245-51. (PMID: 16280048) J Mammary Gland Biol Neoplasia. 2013 Mar;18(1):43-61. (PMID: 23417729) Neurotoxicology. 2014 Dec;45:121-30. (PMID: 25454719) Environ Sci Technol. 2015 May 5;49(9):5261-76. (PMID: 25873211) Environ Health Perspect. 2017 Aug 23;125(8):086004. (PMID: 28858829) Int J Environ Res Public Health. 2016 Feb 26;13(3):null. (PMID: 26927151) Endocrinology. 2015 Dec;156(12):4458-73. (PMID: 26465197) Endocrinology. 2014 Mar;155(3):897-907. (PMID: 24424034) Andrology. 2016 Jul;4(4):673-83. (PMID: 27088260) Sci Total Environ. 2016 Jul 1;557-558:901-10. (PMID: 27073166) J Expo Sci Environ Epidemiol. 2017 Jan;27(1):90-99. (PMID: 26732376) Endocrinology. 2016 Sep;157(9):3469-81. (PMID: 27560547) Environ Health Perspect. 2007 Apr;115(4):592-8. (PMID: 17450229) Fertil Steril. 2016 Sep 15;106(4):795-819. (PMID: 27568524) Sci Total Environ. 2017 Feb 1;579:1781-1793. (PMID: 27939081) Ann Med. 2011 May;43(3):212-34. (PMID: 21417804) Environ Sci Technol. 2002 Apr 15;36(8):1751-6. (PMID: 11993873) Proc Natl Acad Sci U S A. 1976 Nov;73(11):4041-4. (PMID: 1069291) Basic Clin Pharmacol Toxicol. 2008 Feb;102(2):125-33. (PMID: 18226065) New Solut. 2016 Sep 13;:null. (PMID: 27624785) Dev Psychobiol. 2008 May;50(4):353-60. (PMID: 18393277) Endocrinology. 1983 Nov;113(5):1771-80. (PMID: 6605242) Int J Androl. 2008 Apr;31(2):233-40. (PMID: 18248400) |
معلومات مُعتمدة: | K22 ES025811 United States ES NIEHS NIH HHS; R01 ES021394 United States ES NIEHS NIH HHS; R21 ES026395 United States ES NIEHS NIH HHS |
المشرفين على المادة: | 0 (Endocrine Disruptors) |
تواريخ الأحداث: | Date Created: 20180210 Date Completed: 20181105 Latest Revision: 20190301 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC5809159 |
DOI: | 10.1210/en.2017-00866 |
PMID: | 29425295 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1945-7170 |
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DOI: | 10.1210/en.2017-00866 |