دورية أكاديمية
أعرض في EDS

Imaging mass spectrometry of frontal white matter lipid changes in human alcoholics.

التفاصيل البيبلوغرافية
العنوان: Imaging mass spectrometry of frontal white matter lipid changes in human alcoholics.
المؤلفون: de la Monte SM; Department of Pathology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA; Department of Neurology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA; Department of Neurosurgery, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA; Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA. Electronic address: Suzanne_DeLaMonte_MD@Brown.edu., Kay J; Department of Pathology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA; Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA., Yalcin EB; Department of Pathology, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA; Department of Medicine, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA., Kril JJ; Discipline of Pathology, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia., Sheedy D; Discipline of Pathology, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia., Sutherland GT; Discipline of Pathology, Sydney Medical School, University of Sydney, Sydney, NSW 2006, Australia.
المصدر: Alcohol (Fayetteville, N.Y.) [Alcohol] 2018 Mar; Vol. 67, pp. 51-63. Date of Electronic Publication: 2017 Aug 17.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier Science Country of Publication: United States NLM ID: 8502311 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6823 (Electronic) Linking ISSN: 07418329 NLM ISO Abbreviation: Alcohol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York Ny : Elsevier Science
Original Publication: Fayetteville, N.Y. : Ankho International, c1984-
مواضيع طبية MeSH: Alcoholism/*metabolism , Frontal Lobe/*metabolism , Phospholipids/*metabolism , Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/*methods , Sphingolipids/*metabolism , White Matter/*metabolism, Adult ; Aged ; Alcoholics ; Alcoholism/pathology ; Female ; Frontal Lobe/pathology ; Humans ; Male ; Middle Aged ; Principal Component Analysis/methods ; White Matter/pathology
مستخلص: Background: Chronic alcohol use disorders (AUD) are associated with white matter (WM) degeneration with altered myelin integrity. Matrix assisted laser desorption ionization-imaging mass spectrometry (MALDI-IMS) enables high throughput analysis of myelin lipid biochemical histopathology to help characterize disease mechanisms.
Purpose: This study utilized MALDI-IMS to investigate frontal lobe WM myelin lipid abnormalities in AUD.
Methods: Standardized cores of formalin-fixed WM from Brodmann Area 4 (BA4) and BA8/9 of 20 postmortem AUD and 19 control adult human brains were embedded in carboxymethyl-cellulose, cryo-sectioned (8 μm), thaw-mounted onto indium tin oxide (ITO) -coated glass slides, and sublimed with 2,5-dihydroxybenzxoic acid (DHB) matrix. Lipids were imaged by MALDI-time of flight in the negative ionization mode. Data were visualized with FlexImaging software v4.0 and analyzed with ClinProTools v3.0.
Results: Principal component analysis (PCA) and data bar plots of MALDI-IMS data differentiated AUD from control WM. The dominant effect of AUD was to broadly reduce expression of sphingolipids (sulfatides and ceramides) and phospholipids. Data bar plots demonstrated overall similar responses to AUD in BA4 and BA8/9. However, differential regional effects of AUD on WM lipid profiles were manifested by non-overlapping expression or discordant responses to AUD for a subset of lipid ions.
Conclusions: Human AUD is associated with substantial inhibition of frontal lobe WM lipid expression with regional variability in these effects. MALDI-IMS can be used to characterize the nature of AUD-associated lipid biochemical abnormalities for correlation with lifetime exposures and WM degeneration, altered gene expression, and responses to abstinence or treatment.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: F32 AA024018 United States AA NIAAA NIH HHS; R01 AA028408 United States AA NIAAA NIH HHS; R28 AA012725 United States AA NIAAA NIH HHS; R37 AA011431 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: Alcohol-use disorder; Human; Imaging; Mass spectrometry; Neurodegeneration; Phospholipids; Sphingolipids; White matter
المشرفين على المادة: 0 (Phospholipids)
0 (Sphingolipids)
تواريخ الأحداث: Date Created: 20180210 Date Completed: 20180924 Latest Revision: 20230201
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5864118
DOI: 10.1016/j.alcohol.2017.08.004
PMID: 29425959
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-6823
DOI:10.1016/j.alcohol.2017.08.004