دورية أكاديمية
In vitro activities of kappa-carrageenan isolated from red marine alga Hypnea musciformis: Antimicrobial, anticancer and neuroprotective potential.
| العنوان: | In vitro activities of kappa-carrageenan isolated from red marine alga Hypnea musciformis: Antimicrobial, anticancer and neuroprotective potential. |
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| المؤلفون: | Souza RB; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil., Frota AF; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil., Silva J; MARE - Marine and Environmental Sciences Centre, School of Tourism and Maritime Technology, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal., Alves C; MARE - Marine and Environmental Sciences Centre, School of Tourism and Maritime Technology, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal., Neugebauer AZ; MARE - Marine and Environmental Sciences Centre, School of Tourism and Maritime Technology, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal., Pinteus S; MARE - Marine and Environmental Sciences Centre, School of Tourism and Maritime Technology, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal., Rodrigues JAG; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil., Cordeiro EMS; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil., de Almeida RR; Department of Organic and Inorganic Chemistry, Federal University of Ceará, Fortaleza, Ceará, Brazil., Pedrosa R; MARE - Marine and Environmental Sciences Centre, School of Tourism and Maritime Technology, Polytechnic Institute of Leiria, 2520-641 Peniche, Portugal., Benevides NMB; Department of Biochemistry and Molecular Biology, Federal University of Ceará, Fortaleza, Ceará, Brazil. Electronic address: nmbb@ufc.br. |
| المصدر: | International journal of biological macromolecules [Int J Biol Macromol] 2018 Jun; Vol. 112, pp. 1248-1256. Date of Electronic Publication: 2018 Feb 08. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: Guildford, Eng., IPC Science and Technology Press. |
| مواضيع طبية MeSH: | Anti-Bacterial Agents/*pharmacology , Antineoplastic Agents/*pharmacology , Carrageenan/*isolation & purification , Carrageenan/*pharmacology , Neuroprotective Agents/*pharmacology , Rhodophyta/*chemistry, Animals ; Antioxidants/pharmacology ; Cell Death/drug effects ; Cell Line ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Humans ; Mice ; Microbial Sensitivity Tests ; Neurotoxins/toxicity ; Oxidopamine ; Spectroscopy, Fourier Transform Infrared |
| مستخلص: | This study assessed the antioxidant, antimicrobial, anticancer and neuroprotective activities of the kappa(k)-carrageenan isolated from the red alga Hypnea musciformis (Hm-SP). The chemical spectrum of the k-carrageenan from Hm-SP was confirmed by Fourier transform infrared (FT-IR) spectroscopy. Hm-SP revealed an antibacterial and antifungal action against Staphylococcus aureus and Candida albicans, respectively. Hm-SP did not promoted cytotoxic effects against Human breast cancer (MCF-7) and Human neuroblastoma (SH-SY5Y) cell-lines. However, it was observed a significant reduction of the cellular proliferation capacity in these cancer cells in presence of the Hm-SP. Furthermore, Hm-SP showed neuroprotective activity in 6-hydroxydopamine-induced neurotoxicity on SH-SY5Y cells by modulation of the mitochondria transmembrane potential and reducing Caspase 3 activity. In addition, Hm-SP demonstrates low antioxidant potential and did not induce significant cytotoxic effects or changes in the cell proliferation on Balb/c 3T3 mouse fibroblast cell-line. In summary, our data suggest that Hm-SP shows antimicrobial, anticancer and neuprotective activities. (Copyright © 2018 Elsevier B.V. All rights reserved.) |
| المشرفين على المادة: | 0 (Anti-Bacterial Agents) 0 (Antineoplastic Agents) 0 (Antioxidants) 0 (Neuroprotective Agents) 0 (Neurotoxins) 8HW4YBZ748 (Oxidopamine) 9000-07-1 (Carrageenan) |
| تواريخ الأحداث: | Date Created: 20180211 Date Completed: 20180920 Latest Revision: 20180920 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.ijbiomac.2018.02.029 |
| PMID: | 29427681 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-0003 |
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| DOI: | 10.1016/j.ijbiomac.2018.02.029 |