دورية أكاديمية
أعرض في EDS

p38γ and p38δ Are Involved in T Lymphocyte Development.

التفاصيل البيبلوغرافية
العنوان: p38γ and p38δ Are Involved in T Lymphocyte Development.
المؤلفون: Risco A; Department of Immunology and Oncology, Centro Nacional de Biotecnología (CSIC), Madrid, Spain., Martin-Serrano MA; Department of Immunology and Oncology, Centro Nacional de Biotecnología (CSIC), Madrid, Spain., Barber DF; Department of Immunology and Oncology, Centro Nacional de Biotecnología (CSIC), Madrid, Spain., Cuenda A; Department of Immunology and Oncology, Centro Nacional de Biotecnología (CSIC), Madrid, Spain.
المصدر: Frontiers in immunology [Front Immunol] 2018 Jan 29; Vol. 9, pp. 65. Date of Electronic Publication: 2018 Jan 29 (Print Publication: 2018).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Print ISSN: 1664-3224 (Print) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Research Foundation]
مواضيع طبية MeSH: Cell Differentiation*, Mitogen-Activated Protein Kinase 12/*metabolism , Mitogen-Activated Protein Kinase 13/*metabolism , T-Lymphocytes/*cytology , T-Lymphocytes/*metabolism, Animals ; Biomarkers ; Gene Knockdown Techniques ; Lymphoid Tissue/metabolism ; Mice ; Mice, Knockout ; Mitogen-Activated Protein Kinase 12/genetics ; Mitogen-Activated Protein Kinase 13/genetics ; Receptors, Antigen, T-Cell, alpha-beta/metabolism ; Thymocytes/cytology ; Thymocytes/metabolism
مستخلص: p38 mitogen-activated protein kinase (MAPK) signal transduction pathways are essential regulators of the immune response. Particularly, p38γ and p38δ regulate many immune cell functions such as cytokine production, migration, or T cell activation; however, their involvement in immune cell development is largely unknown. Here, we analysed the role of p38 MAPK isoforms p38γ and p38δ in T cell differentiation in the thymus and in lymph nodes, using mice deficient in p38γ, p38δ, or in both. We found that the T cell differentiation program in the thymus was affected at different stages in p38γ-, p38δ-, and p38γ/δ-deficient mice, and also peripheral T cell homaeostasis was compromised. Particularly, p38δ deletion affects different stages of early CD4 - CD8 - double-negative thymocyte development, whereas lack of p38γ favours thymocyte positive selection from CD4 + CD8 + double-positive to CD4 + or CD8 + single-positive cells. Our results identify unreported functions for p38γ and p38δ in T cells.
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فهرسة مساهمة: Keywords: lymph node; p38 mitogen-activated protein kinase; p38γ; p38δ; thymocyte development; thymus
المشرفين على المادة: 0 (Biomarkers)
0 (Receptors, Antigen, T-Cell, alpha-beta)
EC 2.7.1.- (Mitogen-Activated Protein Kinase 12)
EC 2.7.1.- (Mitogen-Activated Protein Kinase 13)
تواريخ الأحداث: Date Created: 20180214 Date Completed: 20190225 Latest Revision: 20190225
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5796910
DOI: 10.3389/fimmu.2018.00065
PMID: 29434594
قاعدة البيانات: MEDLINE
الوصف
تدمد:1664-3224
DOI:10.3389/fimmu.2018.00065