دورية أكاديمية
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Fluorescent nucleobase analogues for base-base FRET in nucleic acids: synthesis, photophysics and applications.

التفاصيل البيبلوغرافية
العنوان: Fluorescent nucleobase analogues for base-base FRET in nucleic acids: synthesis, photophysics and applications.
المؤلفون: Bood M; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96 Gothenburg, Sweden., Sarangamath S; Department of Chemistry and Chemical Engineering, Chemistry and Biochemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden., Wranne MS; Department of Chemistry and Chemical Engineering, Chemistry and Biochemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden., Grøtli M; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96 Gothenburg, Sweden., Wilhelmsson LM; Department of Chemistry and Chemical Engineering, Chemistry and Biochemistry, Chalmers University of Technology, SE-412 96 Gothenburg, Sweden.
المصدر: Beilstein journal of organic chemistry [Beilstein J Org Chem] 2018 Jan 10; Vol. 14, pp. 114-129. Date of Electronic Publication: 2018 Jan 10 (Print Publication: 2018).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Beilstein-Institut Country of Publication: Germany NLM ID: 101250746 Publication Model: eCollection Cited Medium: Print ISSN: 1860-5397 (Print) Linking ISSN: 18605397 NLM ISO Abbreviation: Beilstein J Org Chem Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: [Frankfurt, Germany] : Beilstein-Institut
Original Publication: [Frankfurt, Germany] : [London] : Beilstein-Institut ; in cooperation with BioMed Central, [2005]-
مستخلص: Förster resonance energy transfer (FRET) between a donor nucleobase analogue and an acceptor nucleobase analogue, base-base FRET, works as a spectroscopic ruler and protractor. With their firm stacking and ability to replace the natural nucleic acid bases inside the base-stack, base analogue donor and acceptor molecules complement external fluorophores like the Cy-, Alexa- and ATTO-dyes and enable detailed investigations of structure and dynamics of nucleic acid containing systems. The first base-base FRET pair, tC O -tC nitro , has recently been complemented with among others the adenine analogue FRET pair, qAN1-qA nitro , increasing the flexibility of the methodology. Here we present the design, synthesis, photophysical characterization and use of such base analogues. They enable a higher control of the FRET orientation factor, κ 2 , have a different distance window of opportunity than external fluorophores, and, thus, have the potential to facilitate better structure resolution. Netropsin DNA binding and the B-to-Z-DNA transition are examples of structure investigations that recently have been performed using base-base FRET and that are described here. Base-base FRET has been around for less than a decade, only in 2017 expanded beyond one FRET pair, and represents a highly promising structure and dynamics methodology for the field of nucleic acids. Here we bring up its advantages as well as disadvantages and touch upon potential future applications.
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فهرسة مساهمة: Keywords: B-to-Z-DNA transition; FRET; Z-DNA; fluorescent base analogues; netropsin; nucleic acid structure and dynamics; quadracyclic adenines; tricyclic cytosines
تواريخ الأحداث: Date Created: 20180215 Latest Revision: 20201001
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC5789401
DOI: 10.3762/bjoc.14.7
PMID: 29441135
قاعدة البيانات: MEDLINE
الوصف
تدمد:1860-5397
DOI:10.3762/bjoc.14.7