دورية أكاديمية
Natural Terpenoids Against Female Breast Cancer: A 5-year Recent Research.
| العنوان: | Natural Terpenoids Against Female Breast Cancer: A 5-year Recent Research. |
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| المؤلفون: | Ateba SB; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Cameroon., Mvondo MA; Laboratory of Animal Physiology and Phytopharmacology, Department of Animal Biology, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon., Ngeu ST; Faculty of Health Sciences, Protestant University of Central Africa, P.O. Box 4011 Yaounde, Cameroon., Tchoumtchoua J; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Cameroon.; Division of Pharmacognosy and Natural Products Chemistry, Faculty of Pharmacy, University of Athens, Panepistimioupoli Zografou, 15771 Athens, Greece., Awounfack CF; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Cameroon., Njamen D; Laboratory of Animal Physiology, Department of Animal Biology and Physiology, Faculty of Science, University of Yaounde I, P.O. Box 812 Yaounde, Cameroon., Krenn L; Department of Pharmacognosy, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria. |
| المصدر: | Current medicinal chemistry [Curr Med Chem] 2018; Vol. 25 (27), pp. 3162-3213. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9440157 Publication Model: Print Cited Medium: Internet ISSN: 1875-533X (Electronic) Linking ISSN: 09298673 NLM ISO Abbreviation: Curr Med Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Saif Zone, Sharjah, U.A.E. : Bentham Science Publishers Original Publication: Schiphol, The Netherlands : Bentham Science Publishers, |
| مواضيع طبية MeSH: | Antineoplastic Agents/*pharmacology , Biological Products/*pharmacology , Breast Neoplasms/*drug therapy , Terpenes/*pharmacology, Animals ; Antineoplastic Agents/chemistry ; Biological Products/chemistry ; Breast Neoplasms/pathology ; Cell Proliferation/drug effects ; Female ; Humans ; Terpenes/chemistry |
| مستخلص: | Background: The approval of Taxol® in 1993 marked the great entrance of terpenoids in the anti-cancer area and this drug is still highly important in the treatment of refractory ovarian, breast and other cancers. Over decades, other prominent natural terpenoids have become indispensable for the modern pharmacotherapy of breast cancer. However, given the rapid evolution of drug resistance, effective treatments for advanced breast cancers requiring cytotoxic chemotherapy represent a major unmet clinical need. Therefore, innovative agents effective in long-term chemotherapy are urgently needed. Objective: This review examines recent advances/research about natural terpenoids, and their mechanisms against female breast cancer over the period covering January 1st, 2012 to December 31st, 2016. Results: Carcinogenesis constitutes a multistep process wherein each stage is characterized by distinct phenotypic changes. Numerous chemicals recorded in this review have been shown to significantly inhibit proliferation, migration, apoptosis resistance, tumor angiogenesis or metastasis in different breast cancer cells/tumours in vitro and in vivo. Targeting simultaneously several or all these aspects/steps of cancer progression could be an advantage. In line with this, phytochemicals such as thymoquinone (8), costunolide (46), tanshinone IIA (132), triptolide (136), cucurbitacin B (179), celastrol (226) and lycopene (238) had caught our attention. Conclusion: These compounds appear to be promising to overcome breast cancer treatment failure. However, despite the interesting activities, additional preclinical investigations are needed in further breast cancer cell/tumor models in vitro and in vivo. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.) |
| فهرسة مساهمة: | Keywords: Breast; anti-cancer; breast cancer; breast cancer treatment; carcinogenesis; terpenoids/terpenes. |
| المشرفين على المادة: | 0 (Antineoplastic Agents) 0 (Biological Products) 0 (Terpenes) |
| تواريخ الأحداث: | Date Created: 20180216 Date Completed: 20180913 Latest Revision: 20180913 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2174/0929867325666180214110932 |
| PMID: | 29446727 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1875-533X |
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| DOI: | 10.2174/0929867325666180214110932 |