دورية أكاديمية
Adjunctive antidepressants in bipolar depression: A cohort study of six- and twelve-months rehospitalization rates.
| العنوان: | Adjunctive antidepressants in bipolar depression: A cohort study of six- and twelve-months rehospitalization rates. |
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| المؤلفون: | Shvartzman Y; Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel., Krivoy A; Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel; Geha Mental Health Center, Petach-Tikva, Israel; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Petach-Tikva, Israel., Valevski A; Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel; Geha Mental Health Center, Petach-Tikva, Israel., Gur S; Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel; Geha Mental Health Center, Petach-Tikva, Israel., Weizman A; Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel; Geha Mental Health Center, Petach-Tikva, Israel; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Petach-Tikva, Israel., Hochman E; Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel; Geha Mental Health Center, Petach-Tikva, Israel; Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Petach-Tikva, Israel. |
| المصدر: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2018 Mar; Vol. 28 (3), pp. 353-360. Date of Electronic Publication: 2018 Feb 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7862 (Electronic) Linking ISSN: 0924977X NLM ISO Abbreviation: Eur Neuropsychopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, c1990- |
| مواضيع طبية MeSH: | Antidepressive Agents/*therapeutic use , Antipsychotic Agents/*therapeutic use , Bipolar Disorder/*drug therapy , Hospitalization/*statistics & numerical data, Adult ; Age Factors ; Cohort Studies ; Electronic Health Records/statistics & numerical data ; Female ; Humans ; Male ; Middle Aged ; Psychiatric Status Rating Scales ; Statistics, Nonparametric ; Time Factors ; Treatment Outcome ; Young Adult |
| مستخلص: | Although antidepressants (ADs) are widely used in bipolar depression, there is weak evidence for their effectiveness and safety in this condition. Furthermore, there is a paucity of studies on the risk-benefit ratio of AD maintenance treatment in bipolar disorder (BD). We compared rehospitalization rates of patients with BD-I depressive episode who were discharged with mood stabilizers (MSs) and/or atypical antipsychotics (AAPs) with or without adjunctive AD. Ninety-eight patients with BD-I who were hospitalized with a depressive episode between 2005 and 2013 were retrospectively followed for 6-months and 1-year rehospitalization rates, as well as time to rehospitalization, according to treatment at discharge: MSs and/or AAPs with or without AD. Multivariable survival models adjusted for covariates known to influence rehospitalization were conducted. Six-months and 1-year rehospitalization rates were significantly lower in the adjunctive-AD treatment group compared to the no-AD group (9.2% vs. 36.4%, P = .001, power = 0.87 and 12.3% vs. 42.4%, P = .001, power = 0.89, respectively). Time to rehospitalization within 6-months and 1-year was significantly longer in the adjunctive-AD treatment group (169.9 vs 141 days, P = .001 and 335.6 vs 252.3 days, P = .001, respectively). Adjunctive-AD treatment at discharge reduced significantly the adjusted risk of rehospitalization within 6-months (HR = 0.081, 95% CI: 0.016-0.412, P = 0.002) and 1-year (HR = 0.149, 95% CI: 0.041-0.536, P = 0.004). Moreover, adjunctive-AD treatment did not increase rehospitalization rates of manic episode. In conclusion, adjunctive-AD therapy to MS/AAP at discharge from BD-I depressive episode hospitalization is associated with a lower rate of and a longer time to rehospitalization during a 1-year follow up period. (Copyright © 2018 Elsevier B.V. and ECNP. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Antidepressants; Atypical antipsychotics; Bipolar disorder; Depressive episode; Mood stabilizers; Rehospitalization |
| المشرفين على المادة: | 0 (Antidepressive Agents) 0 (Antipsychotic Agents) |
| تواريخ الأحداث: | Date Created: 20180217 Date Completed: 20190129 Latest Revision: 20190129 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.euroneuro.2018.01.010 |
| PMID: | 29449055 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-7862 |
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| DOI: | 10.1016/j.euroneuro.2018.01.010 |