دورية أكاديمية
Place learning overrides innate behaviors in Drosophila .
| العنوان: | Place learning overrides innate behaviors in Drosophila . |
|---|---|
| المؤلفون: | Baggett V; Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA., Mishra A; Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA., Kehrer AL; Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA., Robinson AO; Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA., Shaw P; Department of Neuroscience, Washington University School of Medicine, St. Louis, Missouri 63110, USA., Zars T; Division of Biological Sciences, University of Missouri, Columbia, Missouri 65211, USA. |
| المصدر: | Learning & memory (Cold Spring Harbor, N.Y.) [Learn Mem] 2018 Feb 15; Vol. 25 (3), pp. 122-128. Date of Electronic Publication: 2018 Feb 15 (Print Publication: 2018). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9435678 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1549-5485 (Electronic) Linking ISSN: 10720502 NLM ISO Abbreviation: Learn Mem Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cold Spring Harbor, NY : Cold Spring Harbor Laboratory Press, c1994- |
| مواضيع طبية MeSH: | Behavior, Animal*/physiology , Conditioning, Operant*/physiology , Spatial Learning*/physiology , Spatial Memory*/physiology, Adenylyl Cyclases/genetics ; Adenylyl Cyclases/metabolism ; Air ; Animals ; Animals, Genetically Modified ; Association Learning/physiology ; Drosophila Proteins/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster ; Gravitation ; Light |
| مستخلص: | Animals in a natural environment confront many sensory cues. Some of these cues bias behavioral decisions independent of experience, and action selection can reveal a stimulus-response (S-R) connection. However, in a changing environment it would be a benefit for an animal to update behavioral action selection based on experience, and learning might modify even strong S-R relationships. How animals use learning to modify S-R relationships is a largely open question. Three sensory stimuli, air, light, and gravity sources were presented to individual Drosophila melanogaster in both naïve and place conditioning situations. Flies were tested for a potential modification of the S-R relationships of anemotaxis, phototaxis, and negative gravitaxis by a contingency that associated place with high temperature. With two stimuli, significant S-R relationships were abandoned when the cue was in conflict with the place learning contingency. The role of the dunce ( dnc ) cAMP-phosphodiesterase and the rutabaga ( rut ) adenylyl cyclase were examined in all conditions. Both dnc 1 and rut 2080 mutant flies failed to display significant S-R relationships with two attractive cues, and have characteristically lower conditioning scores under most conditions. Thus, learning can have profound effects on separate native S-R relationships in multiple contexts, and mutation of the dnc and rut genes reveal complex effects on behavior. (© 2018 Baggett et al.; Published by Cold Spring Harbor Laboratory Press.) |
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| معلومات مُعتمدة: | R01 NS076980 United States NS NINDS NIH HHS |
| المشرفين على المادة: | 0 (Drosophila Proteins) 0 (dnc protein, Drosophila) EC 4.6.1.1 (Adenylyl Cyclases) EC 4.6.1.1 (Rut protein, Drosophila) |
| تواريخ الأحداث: | Date Created: 20180217 Date Completed: 20190214 Latest Revision: 20190614 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5817280 |
| DOI: | 10.1101/lm.046136.117 |
| PMID: | 29449456 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1549-5485 |
|---|---|
| DOI: | 10.1101/lm.046136.117 |