التفاصيل البيبلوغرافية
| العنوان: |
Laser ablative therapy of sessile hypothalamic hamartomas in children using interventional MRI: report of 5 cases. |
| المؤلفون: |
Southwell DG; Departments of1Neurological Surgery and., Birk HS; 2Department of Neurosurgery, University of California, San Diego; and., Larson PS; Departments of1Neurological Surgery and., Starr PA; Departments of1Neurological Surgery and., Sugrue LP; 3Radiology and Biomedical Imaging, University of California, San Francisco.; 4University of California, San Francisco Benioff Children's Hospitals, Oakland and San Francisco, California., Auguste KI; Departments of1Neurological Surgery and.; 4University of California, San Francisco Benioff Children's Hospitals, Oakland and San Francisco, California. |
| المصدر: |
Journal of neurosurgery. Pediatrics [J Neurosurg Pediatr] 2018 May; Vol. 21 (5), pp. 460-465. Date of Electronic Publication: 2018 Feb 16. |
| نوع المنشور: |
Case Reports; Journal Article |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: American Association of Neurological Surgeons Country of Publication: United States NLM ID: 101463759 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-0715 (Electronic) Linking ISSN: 19330707 NLM ISO Abbreviation: J Neurosurg Pediatr Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: Charlottesville, VA : American Association of Neurological Surgeons, 2004- |
| مواضيع طبية MeSH: |
Hamartoma/*surgery , Hypothalamic Diseases/*surgery , Laser Therapy/*methods, Adolescent ; Child ; Child, Preschool ; Chronic Disease ; Female ; Humans ; Magnetic Resonance Imaging, Interventional ; Male ; Seizures/etiology ; Seizures/surgery ; Stereotaxic Techniques ; Surgery, Computer-Assisted/methods ; Treatment Outcome |
| مستخلص: |
Hypothalamic hamartomas (HHs) are benign lesions that cause medically refractory seizures, behavioral disturbances, and endocrine dysfunction. Open resection of HHs does not guarantee seizure freedom and carries a relatively high risk of morbidity. Minimally invasive stereotactic laser ablation has recently been described as an effective and safe alternative for HH treatment. Prior studies have not, however, assessed HH lesion size and morphology, 2 factors that may influence treatment results and, ultimately, the generalizability of their findings. In this paper, the authors describe seizure outcomes for 5 pediatric patients who underwent laser ablation of sessile HHs. Lesions were treated using a frameless, interventional MRI-guided approach, which facilitated laser targeting to specific components of these complex lesions. The authors' experiences in these cases substantiate prior work demonstrating the effectiveness of laser therapy for HHs, while elucidating HH complexity as a potentially important factor in laser treatment planning, and in the interpretation of early studies describing this treatment method. |
| فهرسة مساهمة: |
Keywords: HH = hypothalamic hamartoma; SRT = stereotactic radiofrequency thermocoagulation; San Francisco; UCSF = University of California; hypothalamic hamartoma; iMRI = interventional MRI; interventional MRI; laser ablation; pediatric epilepsy |
| SCR Disease Name: |
Hypothalamic hamartomas |
| تواريخ الأحداث: |
Date Created: 20180217 Date Completed: 20190401 Latest Revision: 20190401 |
| رمز التحديث: |
20221213 |
| DOI: |
10.3171/2017.10.PEDS17292 |
| PMID: |
29451455 |
| قاعدة البيانات: |
MEDLINE |
