دورية أكاديمية
أعرض في EDS

Establishment of the nasal microbiota in the first 18 months of life: Correlation with early-onset rhinitis and wheezing.

التفاصيل البيبلوغرافية
العنوان: Establishment of the nasal microbiota in the first 18 months of life: Correlation with early-onset rhinitis and wheezing.
المؤلفون: Ta LDH; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Yap GC; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Tay CJX; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Lim ASM; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Huang CH; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chu CW; Genome Institute of Singapore, Agency for Science, Technology and Research Singapore, Singapore., De Sessions PF; Genome Institute of Singapore, Agency for Science, Technology and Research Singapore, Singapore., Shek LP; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore., Goh A; Department of Paediatrics, KK Women's and Children's Hospital, Singapore., Van Bever HPS; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore., Teoh OH; Department of Paediatrics, KK Women's and Children's Hospital, Singapore., Soh JY; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore., Thomas B; Department of Paediatrics, KK Women's and Children's Hospital, Singapore., Ramamurthy MB; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore., Goh DYT; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore., Lay C; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Danone Nutricia Research, Singapore., Soh SE; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chan YH; Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Saw SM; Saw Swee Hock School of Public Health, National University of Singapore, Singapore., Kwek K; Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore., Chong YS; Department of Obstetrics & Gynaecology, National University of Singapore, Singapore; Singapore Institute for Clinical Sciences, Agency for Science, Technology and Research Singapore, Singapore., Godfrey KM; MRC Lifecourse Epidemiology Unit and NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom., Hibberd ML; Genome Institute of Singapore, Agency for Science, Technology and Research Singapore, Singapore., Lee BW; Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: paeleebw@nus.edu.sg.
المصدر: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2018 Jul; Vol. 142 (1), pp. 86-95. Date of Electronic Publication: 2018 Feb 13.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol
أسماء مطبوعة: Original Publication: St Louis, Mosby.
مواضيع طبية MeSH: Microbiota* , Respiratory Sounds*/immunology, Nasal Mucosa/*microbiology , Rhinitis/*microbiology, Case-Control Studies ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Nasal Mucosa/immunology ; Rhinitis/immunology ; Singapore
مستخلص: Background: Dynamic establishment of the nasal microbiota in early life influences local mucosal immune responses and susceptibility to childhood respiratory disorders.
Objective: The aim of this case-control study was to monitor, evaluate, and compare development of the nasal microbiota of infants with rhinitis and wheeze in the first 18 months of life with those of healthy control subjects.
Methods: Anterior nasal swabs of 122 subjects belonging to the Growing Up in Singapore Towards Healthy Outcomes (GUSTO) birth cohort were collected longitudinally over 7 time points in the first 18 months of life. Nasal microbiota signatures were analyzed by using 16S rRNA multiplexed pair-end sequencing from 3 clinical groups: (1) patients with rhinitis alone (n = 28), (2) patients with rhinitis with concomitant wheeze (n = 34), and (3) healthy control subjects (n = 60).
Results: Maturation of the nasal microbiome followed distinctive patterns in infants from both rhinitis groups compared with control subjects. Bacterial diversity increased over the period of 18 months of life in control infants, whereas infants with rhinitis showed a decreasing trend (P < .05). An increase in abundance of the Oxalobacteraceae family (Proteobacteria phylum) and Aerococcaceae family (Firmicutes phylum) was associated with rhinitis and concomitant wheeze (adjusted P < .01), whereas the Corynebacteriaceae family (Actinobacteria phylum) and early colonization with the Staphylococcaceae family (Firmicutes phylum; 3 weeks until 9 months) were associated with control subjects (adjusted P < .05). The only difference between the rhinitis and control groups was a reduced abundance of the Corynebacteriaceae family (adjusted P < .05). Determinants of nasal microbiota succession included sex, mode of delivery, presence of siblings, and infant care attendance.
Conclusion: Our results support the hypothesis that the nasal microbiome is involved in development of early-onset rhinitis and wheeze in infants.
(Copyright © 2018 American Academy of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
التعليقات: Comment in: J Allergy Clin Immunol. 2018 Jul;142(1):73-75. (PMID: 29803801)
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معلومات مُعتمدة: RG/15/17/31749 United Kingdom BHF_ British Heart Foundation; MC_U147574226 United Kingdom MRC_ Medical Research Council; MC_UP_A620_1017 United Kingdom MRC_ Medical Research Council; MC_U147574222 United Kingdom MRC_ Medical Research Council; MC_UU_12011/4 United Kingdom MRC_ Medical Research Council; MR/J000094/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: 16S rRNA gene; Aerococcaceae; Corynebacteriaceae; Moraxellaceae; Oxalobacteraceae; Rhinitis; Staphylococcaceae; cesarean section; eczema; infant; nasal microbiota; wheeze
تواريخ الأحداث: Date Created: 20180217 Date Completed: 20190802 Latest Revision: 20220410
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5989928
DOI: 10.1016/j.jaci.2018.01.032
PMID: 29452199
قاعدة البيانات: MEDLINE
الوصف
تدمد:1097-6825
DOI:10.1016/j.jaci.2018.01.032