دورية أكاديمية
Enlarged spleen is associated with low neutrophil and platelet engraftment rates and poor survival after allogeneic stem cell transplantation in patients with acute myeloid leukemia and myelodysplastic syndrome.
| العنوان: | Enlarged spleen is associated with low neutrophil and platelet engraftment rates and poor survival after allogeneic stem cell transplantation in patients with acute myeloid leukemia and myelodysplastic syndrome. |
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| المؤلفون: | Shimomura Y; Department of Hematology, Kobe City Hospital Organization Kobe City Medical Center General Hospital, Minamimati 2-1-1, Minatojima, chuo-ku, Kobe, 650-0047, Japan. shimomura_0119@yahoo.co.jp., Hara M; Department of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan., Katoh D; Department of Hematology, Kobe City Hospital Organization Kobe City Medical Center General Hospital, Minamimati 2-1-1, Minatojima, chuo-ku, Kobe, 650-0047, Japan., Hashimoto H; Department of Cell Therapy, Foundation for Biomedical Research and Innovation, Kobe, Japan., Ishikawa T; Department of Hematology, Kobe City Hospital Organization Kobe City Medical Center General Hospital, Minamimati 2-1-1, Minatojima, chuo-ku, Kobe, 650-0047, Japan. |
| المصدر: | Annals of hematology [Ann Hematol] 2018 Jun; Vol. 97 (6), pp. 1049-1056. Date of Electronic Publication: 2018 Feb 17. |
| نوع المنشور: | Journal Article; Observational Study |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 9107334 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0584 (Electronic) Linking ISSN: 09395555 NLM ISO Abbreviation: Ann Hematol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Berlin : Springer Verlag Original Publication: Berlin ; New York : Springer International, c1991- |
| مواضيع طبية MeSH: | Blood Platelets/*immunology , Graft Rejection/*prevention & control , Hematopoietic Stem Cell Transplantation/*adverse effects , Leukemia, Myeloid, Acute/*therapy , Myelodysplastic Syndromes/*therapy , Neutrophils/*immunology , Splenomegaly/*etiology, Blood Cell Count ; Cohort Studies ; Female ; Graft Rejection/epidemiology ; Graft Rejection/immunology ; Graft Rejection/physiopathology ; Humans ; Imaging, Three-Dimensional ; Japan/epidemiology ; Leukemia, Myeloid, Acute/immunology ; Male ; Myelodysplastic Syndromes/immunology ; Platelet Count ; Retrospective Studies ; Risk ; Severity of Illness Index ; Spleen/diagnostic imaging ; Splenomegaly/diagnostic imaging ; Splenomegaly/epidemiology ; Splenomegaly/physiopathology ; Survival Analysis ; Tomography, X-Ray Computed ; Transplantation, Homologous/adverse effects |
| مستخلص: | Primary graft failure can be a cause of early morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT), as it leads to a high risk of severe infections and bleeding. Splenomegaly is associated with primary graft failure in patients of myelofibrosis, but the association between splenomegaly and outcomes after HSCT in patients with myeloid malignancies has not been previously evaluated. The aim of this study was to investigate the effect of spleen volume on engraftment kinetics in patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). We enrolled 85 patients. The median spleen volume was 146 cm 3 (quartile 88-201 cm 3 ). The adjusted hazard ratios for neutrophil and platelet engraftments were 0.17 (0.07-0.40, p < 0.001) and 0.19 (0.05-0.69, p = 0.011), respectively, for the high-risk group, at a cutoff splenic volume of 320 cm 3 . Overall survival at 3 years after HSCT was significantly poor in the high-risk group with an adjusted hazard ratio of 13.8 (2.61-72.4, p = 0.002). Enlarged spleen was associated with low neutrophil and platelet engraftment rates and poor survival after allogeneic HSCT in patients of AML and MDS. |
| فهرسة مساهمة: | Keywords: Acute myeloid leukemia; Allogeneic stem cell transplantation; Engraftment; Myelodysplastic syndrome; Splenomegaly |
| تواريخ الأحداث: | Date Created: 20180219 Date Completed: 20180427 Latest Revision: 20180427 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s00277-018-3278-9 |
| PMID: | 29455235 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1432-0584 |
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| DOI: | 10.1007/s00277-018-3278-9 |