دورية أكاديمية
أعرض في EDS

Neurons Generated by Mouse ESCs with Hippocampal or Cortical Identity Display Distinct Projection Patterns When Co-transplanted in the Adult Brain.

التفاصيل البيبلوغرافية
العنوان: Neurons Generated by Mouse ESCs with Hippocampal or Cortical Identity Display Distinct Projection Patterns When Co-transplanted in the Adult Brain.
المؤلفون: Terrigno M; Scuola Normale Superiore, Pisa 56126, Italy., Busti I; Neurofarba, University of Florence, Florence 50134, Italy; Istituto di Neuroscienze, CNR, Pisa 56124, Italy., Alia C; Istituto di Neuroscienze, CNR, Pisa 56124, Italy., Pietrasanta M; Istituto di Neuroscienze, CNR, Pisa 56124, Italy., Arisi I; European Brain Research Institute (EBRI) 'Rita Levi-Montalcini', Roma 00161, Italy., D'Onofrio M; European Brain Research Institute (EBRI) 'Rita Levi-Montalcini', Roma 00161, Italy., Caleo M; Istituto di Neuroscienze, CNR, Pisa 56124, Italy., Cremisi F; Scuola Normale Superiore, Pisa 56126, Italy. Electronic address: federico.cremisi@sns.it.
المصدر: Stem cell reports [Stem Cell Reports] 2018 Mar 13; Vol. 10 (3), pp. 1016-1029. Date of Electronic Publication: 2018 Feb 15.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101611300 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-6711 (Electronic) Linking ISSN: 22136711 NLM ISO Abbreviation: Stem Cell Reports Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [Cambridge, MA] : Cell Press, c 2013-
مواضيع طبية MeSH: Hippocampus/*physiology , Motor Cortex/*physiology , Mouse Embryonic Stem Cells/*physiology , Neocortex/*physiology , Neurons/*physiology, Animals ; Axons/physiology ; Cell Differentiation/physiology ; Cells, Cultured ; Mice ; Neurogenesis/physiology ; Transplantation/methods
مستخلص: The capability of generating neural precursor cells with distinct types of regional identity in vitro has recently opened new opportunities for cell replacement in animal models of neurodegenerative diseases. By manipulating Wnt and BMP signaling, we steered the differentiation of mouse embryonic stem cells (ESCs) toward isocortical or hippocampal molecular identity. These two types of cells showed different degrees of axonal outgrowth and targeted different regions when co-transplanted in healthy or lesioned isocortex or in hippocampus. In hippocampus, only precursor cells with hippocampal molecular identity were able to extend projections, contacting CA3. Conversely, isocortical-like cells were capable of extending long-range axonal projections only when transplanted in motor cortex, sending fibers toward both intra- and extra-cortical targets. Ischemic damage induced by photothrombosis greatly enhanced the capability of isocortical-like cells to extend far-reaching projections. Our results indicate that neural precursors generated by ESCs carry intrinsic signals specifying axonal extension in different environments.
(Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.)
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فهرسة مساهمة: Keywords: WNT signaling; axonal extension; axonal projection; cell replacement; hippocampus; isocortex; mouse embryonic stem cells; neuronal identity; stroke; transplantation
تواريخ الأحداث: Date Created: 20180220 Date Completed: 20190212 Latest Revision: 20210109
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC5918192
DOI: 10.1016/j.stemcr.2018.01.010
PMID: 29456186
قاعدة البيانات: MEDLINE
الوصف
تدمد:2213-6711
DOI:10.1016/j.stemcr.2018.01.010