دورية أكاديمية
Shingrix: The New Adjuvanted Recombinant Herpes Zoster Vaccine.
| العنوان: | Shingrix: The New Adjuvanted Recombinant Herpes Zoster Vaccine. |
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| المؤلفون: | James SF; 1 Regis University School of Pharmacy, Denver, CO, USA., Chahine EB; 2 Palm Beach Atlantic University, West Palm Beach, FL, USA., Sucher AJ; 1 Regis University School of Pharmacy, Denver, CO, USA., Hanna C; 3 Saint Joseph Hospital, Denver, CO, USA. |
| المصدر: | The Annals of pharmacotherapy [Ann Pharmacother] 2018 Jul; Vol. 52 (7), pp. 673-680. Date of Electronic Publication: 2018 Feb 18. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Sage Country of Publication: United States NLM ID: 9203131 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1542-6270 (Electronic) Linking ISSN: 10600280 NLM ISO Abbreviation: Ann Pharmacother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Sept. 2013- : Thousand Oaks, CA : Sage Original Publication: Cincinnati, OH : Harvey Whitney Books Co., c1992- |
| مواضيع طبية MeSH: | Herpes Zoster/*prevention & control , Herpes Zoster Vaccine/*administration & dosage , Vaccines, Subunit/*administration & dosage, Herpes Zoster/economics ; Herpes Zoster/epidemiology ; Herpes Zoster Vaccine/adverse effects ; Herpes Zoster Vaccine/economics ; Humans ; Randomized Controlled Trials as Topic ; Treatment Outcome ; Vaccines, Subunit/adverse effects ; Vaccines, Subunit/economics |
| مستخلص: | Objectives: To review the immunogenicity, efficacy, and safety of the herpes zoster subunit vaccine (HZ/su) for use in adult patients for the prevention of shingles. Data Sources: A literature search through PubMed was conducted (June 2008 to October 2017) using the terms shingles vaccine and varicella zoster virus. References from retrieved articles and the prescribing information were also reviewed for any additional material. Study Selection/data Extraction: The literature search was limited to human studies published in English. Randomized controlled, multicenter trials were reviewed and included to evaluate the safety and efficacy of HZ/su. Literature on the epidemiology and pathology of herpes zoster virus infections and recommendations from the Advisory Committee on Immunization Practices (ACIP) were also reviewed. Data Synthesis: HZ/su is a new adjuvanted recombinant vaccine approved by the Food and Drug Administration for the prevention of herpes zoster in adults 50 years of age and older. HZ/su significantly reduced the risk of developing herpes zoster by more than 90% as compared with placebo and displayed a comparable adverse effect profile. The most common local adverse events were injection site pain, redness, and swelling, and the most common systemic adverse events were myalgia, fatigue, and headache. The ACIP recommends the routine use of HZ/su as the preferred vaccine for the prevention of herpes zoster in immunocompetent adults 50 years of age and older. Conclusions: Based on published immunogenicity, efficacy, and safety data, as well as the recent recommendations by the ACIP, HZ/su should be included on both hospital and community pharmacy formularies and recommended to all immunocompetent patients older than 50 years to prevent herpes zoster. |
| فهرسة مساهمة: | Keywords: herpesvirus; immunizations; immunology; infectious disease; vaccines; viral infections |
| المشرفين على المادة: | 0 (Herpes Zoster Vaccine) 0 (Vaccines, Subunit) |
| تواريخ الأحداث: | Date Created: 20180220 Date Completed: 20190918 Latest Revision: 20190918 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/1060028018758431 |
| PMID: | 29457489 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1542-6270 |
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| DOI: | 10.1177/1060028018758431 |