دورية أكاديمية
Acquired Resistance to Antituberculosis Drugs in England, Wales, and Northern Ireland, 2000-2015.
العنوان: | Acquired Resistance to Antituberculosis Drugs in England, Wales, and Northern Ireland, 2000-2015. |
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المؤلفون: | Loutet MG, Davidson JA, Brown T, Dedicoat M, Thomas HL, Lalor MK |
المصدر: | Emerging infectious diseases [Emerg Infect Dis] 2018 Mar; Vol. 24 (3), pp. 524-533. |
نوع المنشور: | Historical Article; Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC) Country of Publication: United States NLM ID: 9508155 Publication Model: Print Cited Medium: Internet ISSN: 1080-6059 (Electronic) Linking ISSN: 10806040 NLM ISO Abbreviation: Emerg Infect Dis Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: Atlanta, GA : National Center for Infectious Diseases, Centers for Disease Control and Prevention (CDC), [1995- |
مواضيع طبية MeSH: | Antitubercular Agents/*pharmacology , Drug Resistance, Bacterial/*drug effects , Mycobacterium tuberculosis/*drug effects , Tuberculosis/*epidemiology, Adolescent ; Adult ; Antitubercular Agents/therapeutic use ; England/epidemiology ; Female ; History, 21st Century ; Humans ; Male ; Northern Ireland/epidemiology ; Retrospective Studies ; Tuberculosis/drug therapy ; Tuberculosis/history ; Tuberculosis/microbiology ; Tuberculosis, Multidrug-Resistant/drug therapy ; Tuberculosis, Multidrug-Resistant/epidemiology ; Tuberculosis, Multidrug-Resistant/history ; Tuberculosis, Multidrug-Resistant/microbiology ; Wales/epidemiology ; Young Adult |
مستخلص: | Among tuberculosis (TB) patients, acquired resistance to anti-TB drugs represents a failure in the treatment pathway. To improve diagnosis and care for patients with drug-resistant TB, we examined the epidemiology and risk factors associated with acquired drug resistance during 2000-2015 among TB patients in England, Wales, and Northern Ireland. We found acquired resistance in 0.2% (158/67,710) of patients with culture-confirmed TB. Using multivariate logistic regression, we identified the following factors associated with acquired drug resistance: having pulmonary disease; initial resistance to isoniazid, rifampin, or both; a previous TB episode; and being born in China or South Africa. Treatment outcomes were worse for patients with than without acquired resistance. Although acquired resistance is rare in the study area, certain patient groups are at higher risk. Identifying these patients and ensuring that adequate resources are available for treatment may prevent acquisition of resistance, thereby limiting transmission of drug-resistant strains of mycobacteria. |
التعليقات: | Comment in: Emerg Infect Dis. 2018 Nov;24(11):2134. (PMID: 30334732) |
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فهرسة مساهمة: | Keywords: England; Northern Ireland; TB; United Kingdom; Wales; acquired resistance; antimicrobial resistance; bacteria; drug resistance; tuberculosis and other mycobacteria |
المشرفين على المادة: | 0 (Antitubercular Agents) |
تواريخ الأحداث: | Date Created: 20180221 Date Completed: 20190116 Latest Revision: 20190116 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5823342 |
DOI: | 10.3201/eid2403.171362 |
PMID: | 29460735 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1080-6059 |
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DOI: | 10.3201/eid2403.171362 |