دورية أكاديمية
Mitochondria-Targeted Antioxidant SkQ1 (10-(6´-Plastoquinonyl)decyltriphenylphosphonium Bromide) Inhibits Mast Cell Degranulation in vivo and in vitro.
| العنوان: | Mitochondria-Targeted Antioxidant SkQ1 (10-(6´-Plastoquinonyl)decyltriphenylphosphonium Bromide) Inhibits Mast Cell Degranulation in vivo and in vitro. |
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| المؤلفون: | Chelombitko MA; Lomonosov Moscow State University, Faculty of Biology, Moscow, 119991, Russia. atma69@yandex.ru., Averina OA, Vasilyeva TV, Pletiushkina OY, Popova EN, Fedorov AV, Chernyak BV, Shishkina VS, Ilinskaya OP |
| المصدر: | Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2017 Dec; Vol. 82 (12), pp. 1493-1503. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: MAIK Nauka/Interperiodica Country of Publication: United States NLM ID: 0376536 Publication Model: Print Cited Medium: Internet ISSN: 1608-3040 (Electronic) Linking ISSN: 00062979 NLM ISO Abbreviation: Biochemistry (Mosc) Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2007->: Moscow : MAIK Nauka/Interperiodica Original Publication: New York, Consultants Bureau [etc.] |
| مواضيع طبية MeSH: | Antioxidants/*pharmacology , Cell Degranulation/*drug effects , Mitochondria/*drug effects , Plastoquinone/*analogs & derivatives, Animals ; Cell Line ; Injections, Intraperitoneal ; Male ; Mast Cells/cytology ; Mast Cells/drug effects ; Mast Cells/metabolism ; Mice ; Mitochondria/metabolism ; Plastoquinone/pharmacology ; Rats ; Reactive Oxygen Species/metabolism ; Skin/pathology |
| مستخلص: | The therapeutic effect of mitochondria-targeted antioxidant 10-(6´-plastoquinonyl)decyltriphenylphosphonium bromide (SkQ1) in experimental models of acute inflammation and wound repair has been shown earlier. It was suggested that the antiinflammatory activity of SkQ1 is related to its ability to suppress inflammatory activation of the vascular endothelium and neutrophil migration into tissues. Here, we demonstrated that SkQ1 inhibits activation of mast cells (MCs) followed by their degranulation and histamine release in vivo and in vitro. Intraperitoneal injections of SkQ1 in the mouse air-pouch model reduced the number of leukocytes in the air-pouch cavity and significantly decreased the histamine content in it, as well as suppressing MC degranulation in the air-pouch tissue. The direct effect of SkQ1 on MCs was studied in vitro in the rat basophilic leukemia RBL-2H3 cell line. SkQ1 inhibited induced degranulation of RBL-2H3 cells. These results suggest that mitochondrial reactive oxygen species are involved in the activation of MCs. It is known that MCs play a crucial role in regulation of vascular permeability by secreting histamine. Suppression of MC degranulation by SkQ1 might be a significant factor in the antiinflammatory activity of this mitochondria-targeted antioxidant. |
| المشرفين على المادة: | 0 (10-(6'-plastoquinonyl)decyltriphenylphosphonium) 0 (Antioxidants) 0 (Reactive Oxygen Species) OAC30J69CN (Plastoquinone) |
| تواريخ الأحداث: | Date Created: 20180301 Date Completed: 20180323 Latest Revision: 20220330 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1134/S0006297917120082 |
| PMID: | 29486699 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1608-3040 |
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| DOI: | 10.1134/S0006297917120082 |