دورية أكاديمية
Potent ACE inhibitors from 5-hydroxy indanone derivatives.
| العنوان: | Potent ACE inhibitors from 5-hydroxy indanone derivatives. |
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| المؤلفون: | Vulupala HR; Organic Chemistry Division II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India, IICT/Pubs./2018/073., Sajja Y; Organic Chemistry Division II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India, IICT/Pubs./2018/073., Bagul PK; Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India; Drug Discovery Research Center, Translational Health Science and Technology Institute, Faridabad 121001, India., Bandla R; Organic Chemistry Division II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India, IICT/Pubs./2018/073., Nagarapu L; Organic Chemistry Division II (CPC), CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India, IICT/Pubs./2018/073. Electronic address: nagarapu@iict.res.in., Benerjee SK; Centre for Chemical Biology, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500007, India; Drug Discovery Research Center, Translational Health Science and Technology Institute, Faridabad 121001, India. |
| المصدر: | Bioorganic chemistry [Bioorg Chem] 2018 Apr; Vol. 77, pp. 660-665. Date of Electronic Publication: 2018 Feb 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| مواضيع طبية MeSH: | Angiotensin-Converting Enzyme Inhibitors/*pharmacology , Indans/*pharmacology , Peptidyl-Dipeptidase A/*metabolism, Angiotensin-Converting Enzyme Inhibitors/chemical synthesis ; Angiotensin-Converting Enzyme Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Indans/chemical synthesis ; Indans/chemistry ; Molecular Structure ; Structure-Activity Relationship |
| مستخلص: | A novel triazole derivatives(±)-2-(hydroxymethyl)-7,8-dihydro-1H-indeno[5,4-b]furan-6(2H)-one (12a-j) were designed and synthesized by the reaction between racemic azide and terminal acetylenes under click chemistry reaction conditions followed by biological evaluation as angiotensin converting enzyme (ACE) inhibitors. β-Amino alcohol derivatives of 1-indanone (15a-l) were synthesized from 5-hydroxy indanone, it was reacted with epichlorohydrin and followed by oxirane ring opening with various piperazine derivatives. Among the newly synthesized compounds 12b (IC (Copyright © 2018 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: ACE inhibitors; Click chemistry; Epi-chlorohydrin; Hypertension; Piperazines; Triazoles; β-Amino alcohols |
| المشرفين على المادة: | 0 (Angiotensin-Converting Enzyme Inhibitors) 0 (Indans) B926Y9U4QN (indacrinone) EC 3.4.15.1 (ACE protein, human) EC 3.4.15.1 (Peptidyl-Dipeptidase A) |
| تواريخ الأحداث: | Date Created: 20180305 Date Completed: 20190114 Latest Revision: 20190114 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.bioorg.2018.02.022 |
| PMID: | 29502027 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2018.02.022 |