دورية أكاديمية
أعرض في EDS

A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions.

التفاصيل البيبلوغرافية
العنوان: A Toxoplasma gondii locus required for the direct manipulation of host mitochondria has maintained multiple ancestral functions.
المؤلفون: Blank ML; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA., Parker ML; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada., Ramaswamy R; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada., Powell CJ; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada., English ED; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA., Adomako-Ankomah Y; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA., Pernas LF; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Workman SD; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada., Boothroyd JC; Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA., Boulanger MJ; Department of Biochemistry and Microbiology, University of Victoria, Victoria, BC, Canada., Boyle JP; Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA, USA.
المصدر: Molecular microbiology [Mol Microbiol] 2018 Jun; Vol. 108 (5), pp. 519-535. Date of Electronic Publication: 2018 Apr 11.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8712028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2958 (Electronic) Linking ISSN: 0950382X NLM ISO Abbreviation: Mol Microbiol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Oxford, OX ; Boston, MA : Blackwell Scientific Publications, c1987-
مواضيع طبية MeSH: Mitochondria/*metabolism , Protozoan Proteins/*chemistry , Protozoan Proteins/*metabolism , Toxoplasma/*physiology , Toxoplasmosis/*parasitology, Adenosine Diphosphate Ribose/chemistry ; Adenosine Diphosphate Ribose/genetics ; Adenosine Diphosphate Ribose/metabolism ; Animals ; Female ; Fibroblasts/cytology ; Fibroblasts/parasitology ; Foreskin/cytology ; Genetic Loci ; Host-Parasite Interactions/physiology ; Humans ; Male ; Mice ; Mice, Inbred BALB C ; Protozoan Proteins/genetics ; Toxoplasma/genetics
مستخلص: The Toxoplasma gondii locus mitochondrial association factor 1 (MAF1) encodes multiple paralogs, some of which mediate host mitochondrial association (HMA). Previous work showed that HMA was a trait that arose in T. gondii through neofunctionalization of an ancestral MAF1 ortholog. Structural analysis of HMA-competent and incompetent MAF1 paralogs (MAF1b and MAF1a, respectively) revealed that both paralogs harbor an ADP ribose binding macro-domain, with comparatively low (micromolar) affinity for ADP ribose. Replacing the 16 C-terminal residues of MAF1b with those of MAF1a abrogated HMA, and we also show that only three residues in the C-terminal helix are required for MAF1-mediated HMA. Importantly these same three residues are also required for the in vivo growth advantage conferred by MAF1b, providing a definitive link between in vivo proliferation and manipulation of host mitochondria. Co-immunoprecipitation assays reveal that the ability to interact with the mitochondrial MICOS complex is shared by HMA-competent and incompetent MAF1 paralogs and mutants. The weak ADPr coordination and ability to interact with the MICOS complex shared between divergent paralogs may represent modular ancestral functions for this tandemly expanded and diversified T. gondii locus.
(© 2018 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: R01 AI073756 United States AI NIAID NIH HHS; R01 AI114655 United States AI NIAID NIH HHS; 148596 Canada CIHR
المشرفين على المادة: 0 (Protozoan Proteins)
20762-30-5 (Adenosine Diphosphate Ribose)
تواريخ الأحداث: Date Created: 20180306 Date Completed: 20190705 Latest Revision: 20240610
رمز التحديث: 20240610
مُعرف محوري في PubMed: PMC6245547
DOI: 10.1111/mmi.13947
PMID: 29505111
قاعدة البيانات: MEDLINE
الوصف
تدمد:1365-2958
DOI:10.1111/mmi.13947