دورية أكاديمية
أعرض في EDS

Secondary traumatic stress increases expression of proteins implicated in peripheral and central sensitization of trigeminal neurons.

التفاصيل البيبلوغرافية
العنوان: Secondary traumatic stress increases expression of proteins implicated in peripheral and central sensitization of trigeminal neurons.
المؤلفون: Hawkins JL; Missouri State University, JVIC-CBLS, 524 North Boonville Avenue, Springfield, MO 65806, United States., Moore NJ; Missouri State University, JVIC-CBLS, 524 North Boonville Avenue, Springfield, MO 65806, United States., Miley D; Missouri State University, JVIC-CBLS, 524 North Boonville Avenue, Springfield, MO 65806, United States., Durham PL; Missouri State University, JVIC-CBLS, 524 North Boonville Avenue, Springfield, MO 65806, United States. Electronic address: pauldurham@missouristate.edu.
المصدر: Brain research [Brain Res] 2018 May 15; Vol. 1687, pp. 162-172. Date of Electronic Publication: 2018 Mar 06.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 0045503 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-6240 (Electronic) Linking ISSN: 00068993 NLM ISO Abbreviation: Brain Res Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam Elsevier/North-Holland Biomedical Press.
مواضيع طبية MeSH: Central Nervous System Sensitization/*physiology , Nerve Tissue Proteins/*metabolism , Neurons/*metabolism , Stress Disorders, Traumatic/*pathology , Trigeminal Ganglion/*pathology , Trigeminal Nucleus, Spinal/*pathology, Animals ; Disease Models, Animal ; Female ; MAP Kinase Kinase 4/metabolism ; MAP Kinase Signaling System/physiology ; Rats ; Rats, Sprague-Dawley ; Stress Disorders, Traumatic/physiopathology ; Swimming
مستخلص: The pathology of migraine, a common neurological disease, involves sensitization and activation of trigeminal nociceptive neurons to promote hyperalgesia and allodynia during an attack. Migraineurs often exhibit characteristics of a hyperexcitable or hypervigilant nervous system. One of the primary reported risk factors for development of a hyperexcitable trigeminal system is chronic, unmanaged stress and anxiety. While primary traumatic stress is a commonly cited risk factor for many pain conditions, exposure to secondary traumatic stress early in life is also thought to be a contributing risk factor. The goal of this study was to investigate cellular changes within the spinal trigeminal nucleus and trigeminal ganglion mediated by secondary traumatic stress. Male Sprague Dawley rats (sender) were subjected to forced swim testing (primary traumatic stress) and were then housed in close visual, olfactory, and auditory proximity to the breeding male and female rats, pregnant female rats, or female rats and their nursing offspring (all receivers). In response to secondary stress, levels of calcitonin gene-related peptide, active forms of the mitogen activated protein kinases ERK, JNK, and p38, and astrocyte expression of glial fibrillary acidic protein were significantly elevated in the spinal trigeminal nucleus in day 45 offspring when compared to naïve offspring. In addition, increased nuclear expression of ERK and p38 was observed in trigeminal ganglion neurons. Our results demonstrate that secondary traumatic stress promotes cellular events associated with prolonged trigeminal sensitization in the offspring, and provides a mechanism of how early life stress may function as a risk factor for migraine.
(Copyright © 2018 Elsevier B.V. All rights reserved.)
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معلومات مُعتمدة: R15 DE024629 United States DE NIDCR NIH HHS
فهرسة مساهمة: Keywords: MAP kinase; Migraine; Secondary traumatic stress; Sensitization; Trigeminal ganglion
المشرفين على المادة: 0 (Nerve Tissue Proteins)
EC 2.7.12.2 (MAP Kinase Kinase 4)
تواريخ الأحداث: Date Created: 20180310 Date Completed: 20190409 Latest Revision: 20190515
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5882570
DOI: 10.1016/j.brainres.2018.03.003
PMID: 29522721
قاعدة البيانات: MEDLINE
الوصف
تدمد:1872-6240
DOI:10.1016/j.brainres.2018.03.003