دورية أكاديمية
أعرض في EDS

Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase.

التفاصيل البيبلوغرافية
العنوان: Treating Cocaine Addiction, Obesity, and Emotional Disorders by Viral Gene Transfer of Butyrylcholinesterase.
المؤلفون: Brimijoin S; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States., Gao Y; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States., Geng L; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States., Chen VP; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, United States.
المصدر: Frontiers in pharmacology [Front Pharmacol] 2018 Feb 27; Vol. 9, pp. 112. Date of Electronic Publication: 2018 Feb 27 (Print Publication: 2018).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Lausanne : Frontiers Media]
مستخلص: Butyrylcholinesterase (BChE), a plasma enzyme that hydrolyses the neurotransmitter, acetylcholine relatively well, with far lower efficiency than acetylcholinesterase (AChE) but with the capability to degrade a broad range of bioactive esters. AChE is universally understood as essential to cholinergic neurotransmission, voluntary muscle performance, and cognition, among other roles, and its catalytic impact is essential for life. A total absence of BChE activity, whether by enzyme inhibition or simple lack of enzyme protein is not only compatible with life, but does not lead to obvious physiologic disturbance. However, very recent studies at Mayo Clinic have amassed support for the concept that BChE does have a true physiological role as a "ghrelin hydrolase" and, pharmacologically, as a cocaine hydrolase. Human subjects and animal mutations that lack functional BChE show higher than normal levels of ghrelin, an acylated peptide that drives hunger and feeding, along with certain emotional behaviors. Mice treated by viral gene transfer of BChE show higher plasma levels of enzyme and lower levels of ghrelin. Ghrelin is acknowledged as a driver of food-seeking and stress. This brief review examines some key phenomena and considers means of modulating BChE as treatments for cocaine addiction, anxiety, aggression, and obesity.
References: Nat Neurosci. 2008 Jul;11(7):752-3. (PMID: 18552842)
Biol Psychiatry. 2012 Sep 15;72(6):457-65. (PMID: 22521145)
Clin Sci (Lond). 1993 Jul;85(1):77-81. (PMID: 8149699)
Chem Biol Interact. 2016 Nov 25;259(Pt B):271-275. (PMID: 26915976)
Gen Comp Endocrinol. 2015 Dec 1;224:61-8. (PMID: 26073531)
Clin Chim Acta. 2007 Mar;378(1-2):128-35. (PMID: 17182021)
Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8628-33. (PMID: 16731619)
Int J Pept. 2010;2010:null. (PMID: 20721341)
Lancet. 1952 Jun 21;1(6721):1229-30. (PMID: 14939769)
Behav Brain Res. 2013 Jul 1;248:7-11. (PMID: 23578756)
Biochem J. 2013 Aug 1;453(3):447-54. (PMID: 23849058)
Drug Alcohol Depend. 1997 Dec 15;48(3):159-65. (PMID: 9449014)
Intern Med. 2007;46(19):1633-9. (PMID: 17917325)
PLoS One. 2013 Jun 28;8(6):e67446. (PMID: 23840704)
Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2251-6. (PMID: 25646463)
Anal Biochem. 2002 Oct 15;309(2):200-5. (PMID: 12413452)
Regul Pept. 2007 May 3;140(3):148-52. (PMID: 17257691)
Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10960-10965. (PMID: 28973869)
Vaccine. 2014 Jul 16;32(33):4155-62. (PMID: 24892251)
Acta Anaesthesiol Scand. 1978;22(4):371-80. (PMID: 726855)
J Cachexia Sarcopenia Muscle. 2013 Mar;4(1):31-9. (PMID: 22956442)
Endocrinology. 2004 Nov;145(11):4997-5005. (PMID: 15256494)
Future Med Chem. 2012 Feb;4(2):151-62. (PMID: 22300095)
Curr Alzheimer Res. 2010 Aug;7(5):386-400. (PMID: 19939227)
Regul Pept. 2005 Feb 15;125(1-3):151-4. (PMID: 15582726)
Mol Psychiatry. 2014 Dec;19(12):1284-94. (PMID: 24126924)
Addict Biol. 2007 Mar;12(1):22-9. (PMID: 17407494)
Mt Sinai J Med. 2010 Jan-Feb;77(1):69-81. (PMID: 20101721)
Mol Pharmacol. 2002 Aug;62(2):220-4. (PMID: 12130672)
Curr Drug Targets. 2016;17 (5):495-507. (PMID: 25981609)
Ann Hepatol. 2012 May-Jun;11(3):356-63. (PMID: 22481455)
Nature. 1948 Jul 31;162(4109):194. (PMID: 18875290)
Chem Biol Interact. 2010 Sep 6;187(1-3):148-52. (PMID: 20060817)
Ann Neurol. 1997 Dec;42(6):909-18. (PMID: 9403484)
Neuroscience. 2011 Sep 29;192:500-6. (PMID: 21699961)
Front Neurosci. 2013 May 29;7:87. (PMID: 23754971)
Addict Biol. 2011 Jul;16(3):386-92. (PMID: 21054685)
Neuropsychopharmacology. 2014 May;39(6):1538-46. (PMID: 24407266)
Biochem Biophys Res Commun. 2002 Dec 20;299(5):739-43. (PMID: 12470640)
فهرسة مساهمة: Keywords: addiction; butyrylcholinesterase; cocaine; ghrelin; obesity; stress; viral gene transfer
تواريخ الأحداث: Date Created: 20180315 Latest Revision: 20201001
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5835039
DOI: 10.3389/fphar.2018.00112
PMID: 29535625
قاعدة البيانات: MEDLINE
الوصف
تدمد:1663-9812
DOI:10.3389/fphar.2018.00112