دورية أكاديمية
Serum Complement C3 and Type 2 Diabetes in Rheumatoid Arthritis: A Case-Control Study.
| العنوان: | Serum Complement C3 and Type 2 Diabetes in Rheumatoid Arthritis: A Case-Control Study. |
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| المؤلفون: | Ursini F; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy.; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., D Angelo S; Rheumatology Department of Lucania, 'San Carlo' Hospital of Potenza and 'Madonna delle Grazie' Hospital of Matera, Potenza, Italy., Russo E; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Ammerata G; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Abenavoli L; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Mauro D; Centre for Experimental Medicine and Rheumatology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom., Bruno C; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Naty S; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Grembiale RD; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy., Olivieri I; Rheumatology Department of Lucania, 'San Carlo' Hospital of Potenza and 'Madonna delle Grazie' Hospital of Matera, Potenza, Italy., De Sarro G; Department of Health Sciences, University of Catanzaro 'Magna Graecia', Catanzaro, Italy. |
| المصدر: | Reviews on recent clinical trials [Rev Recent Clin Trials] 2018; Vol. 13 (3), pp. 215-221. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Bentham Science Pub Country of Publication: United Arab Emirates NLM ID: 101270873 Publication Model: Print Cited Medium: Internet ISSN: 1876-1038 (Electronic) Linking ISSN: 15748871 NLM ISO Abbreviation: Rev Recent Clin Trials Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Saif Zone, Sharjah, U.A.E. ; San Francisco, CA : Bentham Science Pub., c2006- |
| مواضيع طبية MeSH: | Arthritis, Rheumatoid/*blood , Arthritis, Rheumatoid/*complications , Complement C3/*metabolism , Diabetes Mellitus, Type 2/*blood , Diabetes Mellitus, Type 2/*complications, Aged ; Biomarkers/blood ; Case-Control Studies ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; ROC Curve ; Risk Factors |
| مستخلص: | Background: Recent evidence demonstrated a potential role of complement C3 as a candidate biomarker of cardiometabolic risk in the general population. Objective: Aim of the present study was to investigate the correlation between complement C3 levels and comorbid Type 2 Diabetes (T2DM) in Rheumatoid Arthritis (RA) patients. Methods: For the present study, 40 consecutive diabetic RA patients (RA/T2DM+ group) and 80 consecutive RA patients without diabetes (RA/T2DM- group) were recruited. Results: Patients in the RA/T2DM+ group were significantly older (p < 0.0001), had a longer RA duration (p < 0.0001) and higher disease activity (p = 0.006) compared to controls. Moreover, patients in the RA/T2DM+ group had significantly higher levels of ESR (p < 0.0001), CRP (p < 0.0001) and complement C3 (p < 0.0001). A logistic regression model was built to ascertain the effect of selected variables (age, RA duration, BMI, ESR, C3, lnCRP, corticosteroid use) on the likelihood that patients have T2DM. Longer RA duration, ESR and C3 were associated with an increased likelihood of being classified as T2DM. Finally, we built ROC curves to evaluate the predictivity of RA duration, complement C3 and the combination of both variables on the likelihood of being diagnosed with T2DM. The area under the ROC curve was 0.79 (p < 0.0001) for RA duration, 0.71 (p < 0.0001) for complement C3 and 0.89 (p < 0.0001) for the combination of both variables. Conclusion: According to our data complement C3 levels can predict the presence of T2DM in RA patients. (Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.) |
| فهرسة مساهمة: | Keywords: Complement C3; complement system proteins; diabetes mellitus type 2; insulin resistance; prediabetes; rheumatoid arthritis. |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Complement C3) |
| تواريخ الأحداث: | Date Created: 20180316 Date Completed: 20181217 Latest Revision: 20181217 |
| رمز التحديث: | 20231215 |
| DOI: | 10.2174/1574887113666180314092757 |
| PMID: | 29542421 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1876-1038 |
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| DOI: | 10.2174/1574887113666180314092757 |