دورية أكاديمية
أعرض في EDS

Transepithelial Fluid and Salt Re-Absorption Regulated by cGK2 Signals.

التفاصيل البيبلوغرافية
العنوان: Transepithelial Fluid and Salt Re-Absorption Regulated by cGK2 Signals.
المؤلفون: Chang J; Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110122, China. Jian.Chang@uthct.edu.; Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA. Jian.Chang@uthct.edu., Ding Y; Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110122, China. yding@cmu.edu.cn., Zhou Z; Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110122, China. 18842463125@163.com., Nie HG; Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110122, China. hgnie@cmu.edu.cn., Ji HL; Institute of Metabolic Disease Research and Drug Development, China Medical University, Shenyang 110122, China. james.ji@uthct.edu.; Department of Cellular and Molecular Biology, University of Texas Health Science Center at Tyler, Tyler, TX 75708, USA. james.ji@uthct.edu.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2018 Mar 16; Vol. 19 (3). Date of Electronic Publication: 2018 Mar 16.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Transcytosis* , Water-Electrolyte Balance*, Cyclic GMP-Dependent Protein Kinase Type II/*metabolism, Acute Lung Injury/metabolism ; Animals ; Aquaporins/metabolism ; Cystic Fibrosis/metabolism ; Cystic Fibrosis Transmembrane Conductance Regulator/metabolism ; Drug Discovery ; Epithelial Sodium Channels/metabolism ; Epithelium/metabolism ; Humans ; Ion Transport ; Mice ; Sodium-Potassium-Exchanging ATPase/metabolism
مستخلص: Transepithelial fluid and salt re-absorption in epithelial tissues play an important role in fluid and salt homeostasis. In absorptive epithelium, fluid and salt flux is controlled by machinery mainly composed of epithelial sodium channels (ENaC), cystic fibrosis transmembrane conductance regulator (CFTR), Na⁺/H⁺ exchanger (NHE), aquaporin, and sodium potassium adenosine triphosphatase (Na⁺/K⁺-ATPase). Dysregulation of fluid and salt transport across epithelium contributes to the pathogenesis of many diseases, such as pulmonary edema and cystic fibrosis. Intracellular and extracellular signals, i.e., hormones and protein kinases, regulate fluid and salt turnover and resolution. Increasing evidence demonstrates that transepithelial fluid transport is regulated by cyclic guanosine monophosphate-dependent protein kinase (cGK) signals. cGK2 was originally identified and cloned from intestinal specimens, the presence of which has also been confirmed in the kidney and the lung. cGK2 regulates fluid and salt through ENaC, CFTR and NHE. Deficient cGK2 regulation of transepithelial ion transport was seen in acute lung injury, and cGK2 could be a novel druggable target to restore edematous disorder in epithelial tissues.
Competing Interests: The authors declare no conflicts of interest.
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معلومات مُعتمدة: R01 HL134828 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: acute lung injury; cystic fibrosis transmembrane conductance regulator; epithelial sodium channels; fluid and salt re-absorption; protein kinase
المشرفين على المادة: 0 (Aquaporins)
0 (Epithelial Sodium Channels)
126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator)
EC 2.7.11.12 (Cyclic GMP-Dependent Protein Kinase Type II)
EC 7.2.2.13 (Sodium-Potassium-Exchanging ATPase)
تواريخ الأحداث: Date Created: 20180317 Date Completed: 20180831 Latest Revision: 20191210
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC5877742
DOI: 10.3390/ijms19030881
PMID: 29547542
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms19030881