دورية أكاديمية
Evaluation of three polygenic risk score models for the prediction of breast cancer risk in Singapore Chinese.
| العنوان: | Evaluation of three polygenic risk score models for the prediction of breast cancer risk in Singapore Chinese. |
|---|---|
| المؤلفون: | Chan CHT; Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore., Munusamy P; Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore., Loke SY; Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore., Koh GL; Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore., Yang AZY; Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore., Law HY; DNA Diagnostic and Research Laboratory, KK Women's and Children's Hospital, Singapore., Yoon CS; DNA Diagnostic and Research Laboratory, KK Women's and Children's Hospital, Singapore., Wong CY; Department of General Surgery, Singapore General Hospital, Singapore., Yong WS; Department of Surgical Oncology, National Cancer Centre, Singapore., Wong NS; Department of Medical Oncology, National Cancer Centre, Singapore.; Oncocare Cancer Centre, Gleneagles Medical Centre, Singapore., Ng RCH; Department of Medical Oncology, National Cancer Centre, Singapore., Ong KW; Department of Surgical Oncology, National Cancer Centre, Singapore., Madhukumar P; Department of Surgical Oncology, National Cancer Centre, Singapore., Oey CL; Department of Surgical Oncology, National Cancer Centre, Singapore., Ho GH; Department of Surgical Oncology, National Cancer Centre, Singapore.; Koong and Ho Surgery Centre, Singapore., Tan PH; Department of Pathology, Singapore General Hospital, Singapore., Tan MH; Department of Medical Oncology, National Cancer Centre, Singapore.; Institute of Bioengineering and Nanotechnology, Singapore.; Lucence Diagnostics Pte Ltd, Singapore., Ang P; Department of Medical Oncology, National Cancer Centre, Singapore.; Oncocare Cancer Centre, Gleneagles Medical Centre, Singapore., Yap YS; Department of Medical Oncology, National Cancer Centre, Singapore., Lee ASG; Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Centre, Singapore.; Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.; Office of Clinical and Academic Faculty Affairs, Duke-NUS Graduate Medical School, Singapore. |
| المصدر: | Oncotarget [Oncotarget] 2018 Jan 31; Vol. 9 (16), pp. 12796-12804. Date of Electronic Publication: 2018 Jan 31 (Print Publication: 2018). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: eCollection Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, N.Y. : Impact Journals |
| مستخلص: | Genome-wide association studies (GWAS) have proven highly successful in identifying single nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk. The majority of these studies are on European populations, with limited SNP association data in other populations. We genotyped 51 GWAS-identified SNPs in two independent cohorts of Singaporean Chinese. Cohort 1 comprised 1294 BC cases and 885 controls and was used to determine odds ratios (ORs); Cohort 2 had 301 BC cases and 243 controls for deriving polygenic risk scores (PRS). After age-adjustment, 11 SNPs were found to be significantly associated with BC risk. Five SNPs were present in <1% of Cohort 1 and were excluded from further PRS analysis. To assess the cumulative effect of the remaining 46 SNPs on BC risk, we generated three PRS models: Model-1 included 46 SNPs; Model-2 included 11 statistically significant SNPs; and Model-3 included the SNPs in Model-2 but excluded SNPs that were in strong linkage disequilibrium with the others. Across Models-1, -2 and -3, women in the highest PRS quartile had the greatest ORs of 1.894 (95% CI = 1.157-3.100), 2.013 (95% CI = 1.227-3.302) and 1.751 (95% CI = 1.073-2.856) respectively, suggesting a direct correlation between PRS and BC risk. Given the potential of PRS in BC risk stratification, our findings suggest the need to tailor the selection of SNPs to be included in an ethnic-specific PRS model. Competing Interests: CONFLICTS OF INTEREST The authors declare no conflicts of interests. |
| References: | Nat Genet. 2009 Mar;41(3):324-8. (PMID: 19219042) N Engl J Med. 2015 Sep 3;373(10 ):895-907. (PMID: 26287746) Nat Genet. 2014 Aug;46(8):886-90. (PMID: 25038754) Hum Mol Genet. 2015 May 15;24(10):2966-84. (PMID: 25652398) J Natl Cancer Inst. 2011 Mar 2;103(5):425-35. (PMID: 21263130) Breast Cancer Res Treat. 2014 Aug;146(3):503-14. (PMID: 25007960) J Natl Cancer Inst. 2015 Apr 08;107(5):null. (PMID: 25855707) Nat Genet. 2009 May;41(5):585-90. (PMID: 19330027) Nat Genet. 2008 Jun;40(6):703-6. (PMID: 18438407) Breast Cancer Res. 2016 Feb 17;18(1):22. (PMID: 26884359) Breast Cancer Res. 2012 Jan 23;14(1):R17. (PMID: 22269215) Nature. 2007 Jun 28;447(7148):1087-93. (PMID: 17529967) J Natl Cancer Inst. 2010 Jul 7;102(13):972-81. (PMID: 20484103) Hum Mol Genet. 2012 Dec 15;21(24):5373-84. (PMID: 22976474) J Mol Diagn. 2011 May;13(3):305-12. (PMID: 21497291) Carcinogenesis. 2013 Jul;34(7):1520-8. (PMID: 23475944) Cancer Res. 2011 Oct 1;71(19):6240-9. (PMID: 21844186) J Natl Cancer Inst. 2015 Mar 04;107(5):null. (PMID: 25745020) Hum Mol Genet. 2011 Dec 15;20(24):4991-9. (PMID: 21908515) PLoS Genet. 2010 Jul 22;6(7):e1001029. (PMID: 20661439) Breast Cancer Res. 2014 Jun 18;16(3):R64. (PMID: 24941967) Nat Genet. 2012 Jan 22;44(3):312-8. (PMID: 22267197) Oncotarget. 2016 Dec 20;7(51):85483-85491. (PMID: 27863437) Nat Genet. 2009 May;41(5):579-84. (PMID: 19330030) Nat Genet. 2007 Jul;39(7):865-9. (PMID: 17529974) Nat Commun. 2014 Oct 24;5:5303. (PMID: 25342443) Am J Hum Genet. 2015 Jan 8;96(1):5-20. (PMID: 25529635) Breast Cancer Res Treat. 2016 Oct;159(3):433-42. (PMID: 27572337) Nat Genet. 2007 Jul;39(7):870-4. (PMID: 17529973) Breast Cancer Res. 2012 Mar 27;14(2):R56. (PMID: 22452962) PLoS Genet. 2012;8(2):e1002532. (PMID: 22383897) Int J Cancer. 2016 Sep 15;139(6):1303-1317. (PMID: 27087578) PLoS Genet. 2008 Apr 25;4(4):e1000054. (PMID: 18437204) Cancer Epidemiol Biomarkers Prev. 2010 Sep;19(9):2357-65. (PMID: 20699374) Breast Cancer Res Treat. 2017 May;163(1):131-138. (PMID: 28205043) Breast Cancer Res. 2016 Dec 8;18(1):124. (PMID: 27931260) Nat Genet. 2013 Apr;45(4):392-8, 398e1-2. (PMID: 23535733) Cell Rep. 2016 Jul 12;16(2):472-486. (PMID: 27346354) Hum Mol Genet. 2013 Jun 15;22(12):2539-50. (PMID: 23535825) Cancer Epidemiol Biomarkers Prev. 2008 May;17(5):1060-5. (PMID: 18483326) PLoS One. 2012;7(8):e42380. (PMID: 22879957) PLoS Genet. 2010 Jun 24;6(6):e1001002. (PMID: 20585626) Nat Genet. 2010 Jun;42(6):504-7. (PMID: 20453838) J Clin Oncol. 2017 Mar;35(7):743-750. (PMID: 28029312) Am J Hum Genet. 2007 Sep;81(3):559-75. (PMID: 17701901) Hum Genet. 2016 Jan;135(1):137-54. (PMID: 26621531) Oncotarget. 2016 Nov 15;7(46):75457-75467. (PMID: 27705907) Am J Hum Genet. 2013 Dec 5;93(6):1046-60. (PMID: 24290378) Am J Hum Genet. 2013 Apr 4;92(4):489-503. (PMID: 23540573) J Med Genet. 2017 Feb;54(2):111-113. (PMID: 27794048) Cancer Epidemiol Biomarkers Prev. 2014 Apr;23(4):658-69. (PMID: 24493630) Nat Genet. 2013 Apr;45(4):353-61, 361e1-2. (PMID: 23535729) Nat Genet. 2015 Apr;47(4):373-80. (PMID: 25751625) Breast Cancer Res Treat. 2016 Oct;159(3):513-25. (PMID: 27565998) Nat Genet. 2011 Oct 30;43(12):1210-4. (PMID: 22037553) Nat Commun. 2016 Apr 27;7:11375. (PMID: 27117709) Cancer Res. 2017 Oct 1;77(19):5428-5437. (PMID: 28775167) Breast Cancer Res Treat. 2012 Apr;132(2):711-21. (PMID: 22160591) Hum Mol Genet. 2016 Aug 1;25(15):3361-3371. (PMID: 27354352) |
| فهرسة مساهمة: | Keywords: breast cancer; genotyping; polygenic risk score; risk loci; single-nucleotide polymorphism |
| تواريخ الأحداث: | Date Created: 20180322 Latest Revision: 20191120 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC5849174 |
| DOI: | 10.18632/oncotarget.24374 |
| PMID: | 29560110 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1949-2553 |
|---|---|
| DOI: | 10.18632/oncotarget.24374 |