دورية أكاديمية
Correlation of symptoms to serum vitamin D levels?
| العنوان: | Correlation of symptoms to serum vitamin D levels? |
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| المؤلفون: | Sadat-Ali M; College of Medicine, Imam AbdulRahman Bin Faisal University, Dammam, Saudi Arabia. Electronic address: drsadat@hotmail.com., Al Essa ON; Orthopaedic Resident in Training, National Guard Hospital, Dammam, Saudi Arabia., Alani FM; Senior Registrar Orthopaedic Surgeon, King Fahd Hospital of the University, AlKhobar, Saudi Arabia., Al Omar HK; King Fahd Hospital of the University, AlKhobar, Saudi Arabia., Ebrahim WY; Orthopaedic Resident in Training, King Hamad University Hospital, Bahrain. |
| المصدر: | Clinical nutrition ESPEN [Clin Nutr ESPEN] 2018 Apr; Vol. 24, pp. 31-34. Date of Electronic Publication: 2018 Mar 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101654592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4577 (Electronic) Linking ISSN: 24054577 NLM ISO Abbreviation: Clin Nutr ESPEN |
| أسماء مطبوعة: | Original Publication: [Oxford] : Elsevier Ltd., [2015]- |
| مواضيع طبية MeSH: | Vitamin D/*blood , Vitamin D Deficiency/*physiopathology, Adult ; Aged ; Alopecia/blood ; Alopecia/etiology ; Arthralgia/blood ; Arthralgia/etiology ; Blood Glucose/metabolism ; Fatigue/blood ; Fatigue/etiology ; Female ; Health Surveys ; Humans ; Male ; Middle Aged ; Muscle Cramp/blood ; Muscle Cramp/etiology ; Saudi Arabia/epidemiology ; Surveys and Questionnaires ; Vitamin D Deficiency/complications ; Vitamin D Deficiency/epidemiology ; Weight Gain |
| مستخلص: | Background and Objective: Recent studies have shown that vitamin D plays an important role in many disease processes. However, data is lacking which correlates the common symptoms attributed with vitamin D levels. This study was undertaken to find the correlation of symptoms and Vitamin D levels among ethnic Saudi Arabian population. Methods: A structured questionnaire was made and translated in the Arabic language, which included, age, weight and height, ethnicity and marital status. Patients who were visiting orthopaedic clinics for the first time were included after a detailed history, which ruled out any associated metabolic conditions. Patient's biometric data and the answering of the questionnaire were conducted by one of the senior members of the research group. The symptoms which were included in the questionnaire were fatigue, muscle cramps, joint and back pain, blood sugar levels, recurrent infections, hair loss, mood swings, weight gain, irritable bowel, fractures and history of malignancy. All the scores were graded between 1 and 9 (mildest 1 and severe 9) and only for fracture and malignancy it was yes/no answer. A score of ≤4 was accepted as no impact of the vitamin D levels on symptoms and answer of ≥5 was accepted as impact on the symptoms. Residents whose mother tongue was Arabic conducted all interviews. Blood was collected for 25 OHD levels, calcium and parathyroid hormone levels. Deficiency of vitamin D was defined as ≤20 ng/ml, insufficiency 21-29 ng/ml and normal level ≥30 ng/ml. The data was entered in the data base and analyzed using SPSS Inc Version 20. Results: Two hundred one patients completed the questionnaire but for final analysis the data of 187 was available for analysis as in 14 patients some of the data was missing. All were females and the average age was 55.9 ± 12.4 years, weight 78.9 ± 14.2 kg and height was 1.56 ± 7.01 m. The mean calcium level was 9.12 ± 0.33 mg/dl and, parathyroid hormone was 8.1 ± 6.06 pc/ml. The average 25 hydroxy vitamin D3 (25OHD) level was 21.8 ± 10.22 ng/ml. Forty-four (23.5%) of women had a normal vitamin D level, 51 (27.27%) had insufficiency and 92 (49.19%) had deficiency. Patients who complained of muscle cramps had 25OHD level of 18.86 ± 8.73 compared to patients who had no complains of cramps, 23.45 ± 9.2 ng/ml (p < 0.001) and symptom severity score (SSC) p value of p < 0.000. The results were similar for fatigue, Back pain, hair loss, mood swings and weight gain of P < 0.04, p < 0.07, p < 0.05, <0.03 and p < 0.09 for vitamin D levels and p < 0.001 for SSS. Forty-eight (25.6%) had a previous fracture in their history. Conclusions: This study shows that many symptoms, which have been attributed to low vitamin D levels, are not true. Muscle Cramps, fatigue, mood swings, hair loss, back pain and weight gains appears to be more common in patients with low 25OHD levels. (Copyright © 2018 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Correlation; Symptoms; Vitamin D; Vitamin D deficiency |
| المشرفين على المادة: | 0 (Blood Glucose) 1406-16-2 (Vitamin D) |
| تواريخ الأحداث: | Date Created: 20180327 Date Completed: 20190725 Latest Revision: 20190725 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.clnesp.2018.02.004 |
| PMID: | 29576359 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2405-4577 |
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| DOI: | 10.1016/j.clnesp.2018.02.004 |