دورية أكاديمية
Epigenetic Downregulation and Growth Inhibition of IGFBP7 in Gastric Cancer
| العنوان: | Epigenetic Downregulation and Growth Inhibition of IGFBP7 in Gastric Cancer |
|---|---|
| المؤلفون: | Kim J; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.; Department of Pathology, Seoul National University College of Medicine, Seoul, Korea. Email: everest@snu.ac.kr, Kim WH, Byeon SJ, Lee BL, Kim MA |
| المصدر: | Asian Pacific journal of cancer prevention : APJCP [Asian Pac J Cancer Prev] 2018 Mar 27; Vol. 19 (3), pp. 667-675. Date of Electronic Publication: 2018 Mar 27. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Asian Pacific Organization for Cancer Prevention Country of Publication: Thailand NLM ID: 101130625 Publication Model: Electronic Cited Medium: Internet ISSN: 2476-762X (Electronic) Linking ISSN: 15137368 NLM ISO Abbreviation: Asian Pac J Cancer Prev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bangkok : Asian Pacific Organization for Cancer Prevention, |
| مواضيع طبية MeSH: | Apoptosis* , Epigenomics* , Gene Expression Regulation, Neoplastic*, Adenocarcinoma/*pathology , Biomarkers, Tumor/*metabolism , Insulin-Like Growth Factor Binding Proteins/*metabolism , Stomach Neoplasms/*pathology, Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Biomarkers, Tumor/genetics ; Cell Movement ; Cell Proliferation ; DNA Methylation ; Female ; Follow-Up Studies ; Humans ; Insulin-Like Growth Factor Binding Proteins/genetics ; Male ; Middle Aged ; Prognosis ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Tumor Cells, Cultured |
| مستخلص: | Background: Insulin-like growth factor-binding protein 7 (IGFBP7) has been found to be a tumor suppressor in several human cancers, but the role of IGFBP7 in gastric cancer has not yet been fully investigated. Herein, we examined the epigenetic downregulation of IGFBP7 expression in gastric cancer. Methods: Expression and methylation of IGFBP7 in gastric cancer cells and primary gastric cancer patients were determined using qRT-PCR, western blot, immunohistochemistry, and methylation specific-PCR, respectively. The effects of IGFBP7 on gastric cancer cells were investigated by various experimental conditions, such as proliferation, colony formation, apoptosis, invasion, and migration assay. Results: IGFBP7 methylation was inversely correlated with IGFBP7 expression in gastric cancer. Univariate and multivariate analysis showed that IGFBP7 expression and tumor stage were independent prognostic factors. IGFBP7 knockdown increased gastric cancer cell growth, invasion, and migration, whereas IGFBP7 overexpression in gastric cancer cells induced cell growth inhibition and apoptosis. Conclusion: Our data suggest that IGFBP7 functions as a tumor suppressor in gastric cancer via an epigenetic pathway. (Creative Commons Attribution License) |
| References: | Oncol Rep. 2013 Apr;29(4):1308-14. (PMID: 23381221) Breast Cancer Res Treat. 1998 Feb;47(3):283-93. (PMID: 9516082) Lancet Oncol. 2002 May;3(5):298-302. (PMID: 12067807) Cancer Res. 2010 Jul 15;70(14):6047-58. (PMID: 20587515) J Gastroenterol. 2000;35 Suppl 12:111-5. (PMID: 10779229) Nat Rev Cancer. 2012 Feb 16;12(3):159-69. (PMID: 22337149) Cancer Sci. 2011 Jan;102(1):253-9. (PMID: 21040219) Breast Cancer Res Treat. 2012 Jun;133(2):563-73. (PMID: 21997538) J Biol Chem. 1996 Nov 29;271(48):30322-5. (PMID: 8939990) Cancer Genet Cytogenet. 2010 Feb;197(1):16-24. (PMID: 20113832) Endocr Rev. 2007 Feb;28(1):20-47. (PMID: 16931767) J Pathol. 2007 May;212(1):83-90. (PMID: 17334979) Int J Cancer. 2012 Jan 15;130(2):319-27. (PMID: 21328580) J Urol. 2012 Oct;188(4):1354-60. (PMID: 22906661) Cell Death Dis. 2014 Jun 26;5:e1300. (PMID: 24967962) Ann Surg Oncol. 2012 Nov;19(12):3971-8. (PMID: 22622471) Histol Histopathol. 2002 Jan;17 (1):323-9. (PMID: 11813881) Neoplasia. 2008 Dec;10(12):1335-42. (PMID: 19048112) J Natl Cancer Inst. 2005 Aug 3;97(15):1124-32. (PMID: 16077070) Oncogene. 2010 Jul 1;29(26):3835-44. (PMID: 20440262) Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12981-6. (PMID: 9371786) Cancer Lett. 2011 Aug 28;307(2):200-10. (PMID: 21536375) Cancer Lett. 2001 Aug 28;169(2):155-64. (PMID: 11431104) Eur J Cancer. 2005 Jul;41(11):1515-27. (PMID: 15979304) Endocr Rev. 2000 Jun;21(3):215-44. (PMID: 10857553) |
| فهرسة مساهمة: | Keywords: IGFBP7*; gastric cancer*; tumor suppressor*; downregulation*; methylation* |
| المشرفين على المادة: | 0 (Biomarkers, Tumor) 0 (Insulin-Like Growth Factor Binding Proteins) 0 (insulin-like growth factor binding protein-related protein 1) |
| تواريخ الأحداث: | Date Created: 20180328 Date Completed: 20180919 Latest Revision: 20181114 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC5980839 |
| DOI: | 10.22034/APJCP.2018.19.3.667 |
| PMID: | 29580038 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2476-762X |
|---|---|
| DOI: | 10.22034/APJCP.2018.19.3.667 |