دورية أكاديمية
أعرض في EDS

Vancomycin-resistant Enterococcus faecium sequence type 796 - rapid international dissemination of a new epidemic clone.

التفاصيل البيبلوغرافية
العنوان: Vancomycin-resistant Enterococcus faecium sequence type 796 - rapid international dissemination of a new epidemic clone.
المؤلفون: Mahony AA; 1Department of Infectious Diseases, Austin Health, 145 Studley Rd, Heidelberg, VIC 3084 Australia.; 2Department of Medicine, The University of Melbourne, Heidelberg, VIC 3084 Australia., Buultjens AH; 3Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000 Australia., Ballard SA; 1Department of Infectious Diseases, Austin Health, 145 Studley Rd, Heidelberg, VIC 3084 Australia.; 4Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000 Australia., Grabsch EA; 5Department of Microbiology, Austin Health, Heidelberg, VIC 3084 Australia., Xie S; 5Department of Microbiology, Austin Health, Heidelberg, VIC 3084 Australia., Seemann T; 6Melbourne Bioinformatics, The University of Melbourne, Parkville, VIC 3010 Australia., Stuart RL; 7Monash Infectious Diseases, Monash Health, Clayton, VIC 3168 Australia., Kotsanas D; 7Monash Infectious Diseases, Monash Health, Clayton, VIC 3168 Australia., Cheng A; 8Department of Infectious Diseases, Alfred Health, School of Public Health and Preventive Medicine, Monash University, Prahran, VIC 3181 Australia., Heffernan H; 9Antimicrobial Reference Laboratory, Institute of Environmental Science and Research (ESR), Wellington, 5022 New Zealand., Roberts SA; 10Department of Clinical Microbiology, Auckland District Health Board, Auckland, 1051 New Zealand., Coombs GW; 11School of Veterinary and Life Sciences, Murdoch University, Murdoch, WA 6150 Australia.; 12Microbiology Department, PathWest Laboratory Medicine - WA, Fiona Stanley Hospital, Murdoch, WA 6150 Australia., Bak N; 13Department of Infectious Diseases, Royal Adelaide Hospital, Adelaide, South Australia 5000 Australia., Ferguson JK; Division of Microbiology, Health Pathology, NSW Department of Immunology and Infectious Diseases, John Hunter Hospital, University of Newcastle, Newcastle, NSW 2305 Australia., Carter GC; 4Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000 Australia., Howden BP; 3Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000 Australia.; 4Microbiological Diagnostic Unit Public Health Laboratory, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000 Australia., Stinear TP; 3Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000 Australia., Johnson PDR; 1Department of Infectious Diseases, Austin Health, 145 Studley Rd, Heidelberg, VIC 3084 Australia.; 2Department of Medicine, The University of Melbourne, Heidelberg, VIC 3084 Australia.; 3Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000 Australia.
المصدر: Antimicrobial resistance and infection control [Antimicrob Resist Infect Control] 2018 Mar 22; Vol. 7, pp. 44. Date of Electronic Publication: 2018 Mar 22 (Print Publication: 2018).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101585411 Publication Model: eCollection Cited Medium: Internet ISSN: 2047-2994 (Electronic) Linking ISSN: 20472994 NLM ISO Abbreviation: Antimicrob Resist Infect Control Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مواضيع طبية MeSH: Molecular Epidemiology*, Enterococcus faecium/*drug effects , Enterococcus faecium/*genetics , Gram-Positive Bacterial Infections/*epidemiology , Vancomycin/*pharmacology , Vancomycin-Resistant Enterococci/*genetics, Australia/epidemiology ; Bacterial Proteins/genetics ; Cross Infection/epidemiology ; Enterococcus faecium/isolation & purification ; Enterococcus faecium/pathogenicity ; Epidemics ; Gram-Positive Bacterial Infections/microbiology ; Hospitals ; Humans ; Infection Control ; Intensive Care Units, Neonatal ; Microbial Sensitivity Tests ; New Zealand/epidemiology ; Phylogeny ; Whole Genome Sequencing
مستخلص: Background: Vancomycin-resistant Enterococcus faecium (VRE) is a leading cause of hospital-acquired infections. New, presumably better-adapted strains of VRE appear unpredictably; it is uncertain how they spread despite improved infection control. We aimed to investigate the relatedness of a novel sequence type (ST) of vanB E. faecium - ST796 - very near its time of origin from hospitals in three Australian states and New Zealand.
Methods: Following near-simultaneous outbreaks of ST796 in multiple institutions, we gathered then tested colonization and bloodstream infection isolates' antimicrobial resistance (AMR) phenotypes, and phylogenomic relationships using whole genome sequencing (WGS). Patient meta-data was explored to trace the spread of ST796.
Results: A novel clone of vanB E. faecium (ST796) was first detected at one Australian hospital in late 2011, then in two New Zealand hospitals linked by inter-hospital transfers from separate Melbourne hospitals. ST796 also appeared in hospitals in South Australia and New South Wales and was responsible for at least one major colonization outbreak in a Neonatal Intensive Care Unit without identifiable links between centers. No exceptional AMR was detected in the isolates. While WGS analysis showed very limited diversity at the core genome, consistent with recent emergence of the clone, clustering by institution was observed.
Conclusions: Evolution of new E. faecium clones, followed by recognized or unrecognized movement of colonized individuals then rapid intra-institutional cross-transmission best explain the multi-center, multistate and international outbreak we observed.
Competing Interests: VRE isolates were collected and compared, along with rates of bloodstream infection, using non-identifying data as part of standard infection control procedures under appropriately constituted infection control committees at each institution.Not applicable.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
References: Lancet. 2001 Mar 17;357(9259):855-6. (PMID: 11265957)
Antimicrob Agents Chemother. 2005 May;49(5):1688-94. (PMID: 15855482)
J Clin Microbiol. 2002 Jun;40(6):1963-71. (PMID: 12037049)
mBio. 2013 Aug 20;4(4):. (PMID: 23963180)
J Clin Microbiol. 2008 Jun;46(6):1961-4. (PMID: 18434564)
mBio. 2012 Jul 17;3(4):e00151-12. (PMID: 22807567)
PeerJ. 2017 Jan 24;5:e2916. (PMID: 28149688)
mBio. 2013 Aug 13;4(4):. (PMID: 23943759)
Commun Dis Intell Q Rep. 2014 Dec 31;38(4):E320-6. (PMID: 25631594)
Am J Infect Control. 2015 Oct 1;43(10):1061-5. (PMID: 26190380)
PLoS One. 2012;7(1):e30187. (PMID: 22291916)
Microb Genom. 2016 Jan 19;2(1):. (PMID: 27713836)
Sci Transl Med. 2018 Aug 1;10(452):. (PMID: 30068573)
Med J Aust. 2015 Mar 16;202(5):234-6. (PMID: 25758685)
J Clin Microbiol. 2013 Oct;51(10):3374-9. (PMID: 23926167)
Antimicrob Agents Chemother. 2008 Mar;52(3):1195-7. (PMID: 18180361)
Intern Med J. 2015 Oct;45(10):1037-43. (PMID: 26178306)
Commun Dis Intell Q Rep. 2014 Sep 30;38(3):E247-52. (PMID: 25391408)
J Antimicrob Chemother. 2017 Jan;72(1):48-55. (PMID: 27655856)
Clin Microbiol Infect. 2014 Feb;20(2):145-51. (PMID: 23647880)
J Hosp Infect. 2012 Dec;82(4):234-42. (PMID: 23103245)
PLoS One. 2010 Mar 10;5(3):e9490. (PMID: 20224823)
Chin Med J (Engl). 2012 Oct;125(19):3450-7. (PMID: 23044305)
J Infect Dis. 2010 Oct 15;202(8):1278-86. (PMID: 20812846)
Appl Environ Microbiol. 2015 Mar;81(5):1820-31. (PMID: 25548052)
Commun Dis Intell Q Rep. 2016 Jun 30;40(2):E236-43. (PMID: 27522135)
J Clin Microbiol. 2014 Mar;52(3):897-905. (PMID: 24391201)
PLoS Comput Biol. 2015 Feb 12;11(2):e1004041. (PMID: 25675341)
PLoS One. 2011;6(12):e29189. (PMID: 22195020)
فهرسة مساهمة: Keywords: Infection control; Molecular epidemiology; Outbreak; VRE; Whole genome sequencing
المشرفين على المادة: 0 (Bacterial Proteins)
0 (VanB protein, Enterococcus)
6Q205EH1VU (Vancomycin)
تواريخ الأحداث: Date Created: 20180329 Date Completed: 20190719 Latest Revision: 20240314
رمز التحديث: 20240314
مُعرف محوري في PubMed: PMC5863837
DOI: 10.1186/s13756-018-0335-z
PMID: 29588851
قاعدة البيانات: MEDLINE
الوصف
تدمد:2047-2994
DOI:10.1186/s13756-018-0335-z