دورية أكاديمية

Association of pesticide exposure with human congenital abnormalities.

التفاصيل البيبلوغرافية
العنوان: Association of pesticide exposure with human congenital abnormalities.
المؤلفون: Kalliora C; Medical School, University of Crete, Heraklion, Crete, Greece; Department of Pharmacology, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA., Mamoulakis C; Department of Urology, University General Hospital of Heraklion, University of Crete, Medical School, Heraklion, Crete, Greece. Electronic address: mamoulak@uoc.gr., Vasilopoulos E; Department of Biology, Temple University, Philadelphia, PA, USA., Stamatiades GA; Division of Endocrinology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Kalafati L; Department of Biology, University of Crete, Greece., Barouni R; Department of Biology, University of Athens, Greece., Karakousi T; Department of Biology, University of Crete, Greece., Abdollahi M; Department of Toxicology & Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran, Iran., Tsatsakis A; Department of Toxicology & Forensic Science, Medical School, University of Crete, Voutes Campus, Heraklion 71003, Greece.
المصدر: Toxicology and applied pharmacology [Toxicol Appl Pharmacol] 2018 May 01; Vol. 346, pp. 58-75. Date of Electronic Publication: 2018 Mar 26.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0416575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0333 (Electronic) Linking ISSN: 0041008X NLM ISO Abbreviation: Toxicol Appl Pharmacol Subsets: MEDLINE
أسماء مطبوعة: Publication: New York, NY : Academic Press
Original Publication: New York.
مواضيع طبية MeSH: Abnormalities, Drug-Induced/*etiology , Congenital Abnormalities/*etiology , Environmental Exposure/*adverse effects , Occupational Exposure/*adverse effects , Pesticides/*adverse effects, Animals ; Humans
مستخلص: Human pesticide exposure can occur both occupationally and environmentally during manufacture and after the application of indoor and outdoor pesticides, as well as through consumption via residues in food and water. There is evidence from experimental studies that numerous pesticides, either in isolation or in combination, act as endocrine disruptors, neurodevelopmental toxicants, immunotoxicants, and carcinogens. We reviewed the international literature on this subject for the years between 1990 and 2017. The studies were considered in this review through MEDLINE and WHO resources. Out of the n = 1817 studies identified, n = 94 were reviewed because they fulfilled criteria of validity and addressed associations of interest. Epidemiological studies have provided limited evidence linking pre- and post-natal exposure to pesticides with cancers in childhood, neurological deficits, fetal death, intrauterine growth restriction, preterm birth, and congenital abnormalities (CAs). In this review, the potential association between pesticide exposure and the appearance of some human CAs (including among others musculoskeletal abnormalities; neural tube defects; urogenital and cardiovascular abnormalities) was investigated. A trend towards a positive association between environmental or occupational exposure to some pesticides and some CAs was detected, but this association remains to be substantiated. Main limitations of the review include inadequate exposure assessment and limited sample size. Adequately powered studies with precise exposure assessments such as biomonitoring, are warranted to clarify with certainty the potential association between pesticide exposure and human CAs.
(Copyright © 2018 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: T32 DK007529 United States DK NIDDK NIH HHS
فهرسة مساهمة: Keywords: Congenital abnormalities; Ecotoxicology; Human; Musculoskeletal abnormalities; Neural tube defects; Pesticides; Urogenital abnormalities
المشرفين على المادة: 0 (Pesticides)
تواريخ الأحداث: Date Created: 20180330 Date Completed: 20181011 Latest Revision: 20240328
رمز التحديث: 20240329
مُعرف محوري في PubMed: PMC6029725
DOI: 10.1016/j.taap.2018.03.025
PMID: 29596925
قاعدة البيانات: MEDLINE
الوصف
تدمد:1096-0333
DOI:10.1016/j.taap.2018.03.025