دورية أكاديمية
Peel flour of Passiflora edulis Var. Flavicarpa supplementation prevents the insulin resistance and hepatic steatosis induced by low-fructose-diet in young rats.
| العنوان: | Peel flour of Passiflora edulis Var. Flavicarpa supplementation prevents the insulin resistance and hepatic steatosis induced by low-fructose-diet in young rats. |
|---|---|
| المؤلفون: | Goss MJ; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil., Nunes MLO; NIQFAR CCS, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil., Machado ID; NIQFAR CCS, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil., Merlin L; NIQFAR CCS, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil., Macedo NB; Departamento de Nutrição (DNUT) da Universidade Federal de Sergipe (UFS), Avenida Marechal Rondon, s/n - Rosa Elze, São Cristóvão, SE, CEP 49100-000, Brazil., Silva AMO; Departamento de Nutrição (DNUT) da Universidade Federal de Sergipe (UFS), Avenida Marechal Rondon, s/n - Rosa Elze, São Cristóvão, SE, CEP 49100-000, Brazil., Bresolin TMB; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil; NIQFAR CCS, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil., Santin JR; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil; NIQFAR CCS, Universidade do Vale do Itajaí, Rua Uruguai, 458, Itajaí, SC, CEP 88302-202, Brazil. Electronic address: jrs.santin@univali.br. |
| المصدر: | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2018 Jun; Vol. 102, pp. 848-854. Date of Electronic Publication: 2018 Apr 05. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Paris : Editions Scientifiques Elsevier Original Publication: New York, N.Y. : Masson Pub. USA, Inc., c1982- |
| مواضيع طبية MeSH: | Diet* , Flour* , Insulin Resistance*, Fatty Liver/*drug therapy , Fatty Liver/*prevention & control , Passiflora/*chemistry , Plant Extracts/*therapeutic use, Adipose Tissue/drug effects ; Adipose Tissue/pathology ; Aging/pathology ; Animals ; Antioxidants/pharmacology ; Fatty Liver/blood ; Fatty Liver/pathology ; Fructose ; Lipids/blood ; Liver/drug effects ; Liver/pathology ; Male ; Plant Extracts/pharmacology ; Rats, Wistar ; Weight Gain/drug effects |
| مستخلص: | The increase in fructose consumption in the last decades has an important correlation with the growth of overweight population. Fructose is a monosaccharide found in fruits, vegetables and honey, however, it is widely used in processed food and beverages such as sweeteners. This monosaccharide is metabolized in the liver, so it can produce glucose, lactate, triglycerides, free fatty acids and uric acid, which are responsible for negative effects on the liver and extrahepatic tissues. One effect of the high consumption of fructose is the resistance to Insulin, which appears to be an important issue in the development of metabolic abnormalities observed in animals that were subjected to a high fructose diet. The population and, consequently, the market search for natural sources to manage metabolic abnormalities is increasing, but, adequate scientific proof still is necessary. The Passiflora edulis peel flour (PEPF) is a byproduct of the juice industry, and, represents an important source of fiber and bioactive compounds. The present study investigates the PEPF supplementation (30%) effects on insulin sensitivity, adiposity and metabolic parameters in young rats that were given beverages enriched with 10% of fructose for 8 weeks. Fructose intake induced insulin resistance, increased serum triglycerides levels, growth of fat deposits in the liver and widening of the diameter of adipocytes. In contrast, the group that received PEPF did not present such abnormalities, which could be related to the presence of fiber or bioactive compounds (phenolics compounds, e.g., caffeic acid and isoorientin) in its composition, as identified by analytical methods. Thus, for the first time, it has been demonstrated that PEPF supplementation prevents insulin resistance and hepatic steatosis induced by low-fructose-diet in young rats. (Copyright © 2018 Elsevier Masson SAS. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Diabetes; Insulin resistance; Liver injury; Passiflora edulis peel flour |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Lipids) 0 (Plant Extracts) 30237-26-4 (Fructose) |
| تواريخ الأحداث: | Date Created: 20180402 Date Completed: 20181002 Latest Revision: 20181004 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.biopha.2018.03.137 |
| PMID: | 29605773 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1950-6007 |
|---|---|
| DOI: | 10.1016/j.biopha.2018.03.137 |