دورية أكاديمية
High-Density Lipoproteins: Effects on Vascular Function and Role in the Immune Response.
| العنوان: | High-Density Lipoproteins: Effects on Vascular Function and Role in the Immune Response. |
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| المؤلفون: | Haghikia A; Department of Cardiology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin 12203, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Postfach 65 21 33, Berlin 13316, Germany. Electronic address: arash.haghikia@charite.de., Landmesser U; Department of Cardiology, Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, Berlin 12203, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Berlin, Postfach 65 21 33, Berlin 13316, Germany; Berlin Institute of Health (BIH), Anna-Louisa-Karsch-Straße 2, Berlin 10178, Germany. |
| المصدر: | Cardiology clinics [Cardiol Clin] 2018 May; Vol. 36 (2), pp. 317-327. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8300331 Publication Model: Print Cited Medium: Internet ISSN: 1558-2264 (Electronic) Linking ISSN: 07338651 NLM ISO Abbreviation: Cardiol Clin Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2005- : Amsterdam : Elsevier Original Publication: Philadelphia : Saunders, c1983- |
| مواضيع طبية MeSH: | Blood Vessels/*physiopathology , Coronary Artery Disease/*blood , Immunity, Innate/*physiology , Lipid Metabolism/*immunology , Lipoproteins, HDL/*physiology , Vasodilation/*physiology, Coronary Artery Disease/immunology ; Humans ; Prognosis ; Risk Factors |
| مستخلص: | The focus in studies of high-density lipoproteins was on their capacity to remove excess cholesterol and deliver it to the liver. Other functions and vascular effects have been described. Clinical trials and translational/genetic studies have led to a refined understanding of the role of high-density lipoprotein; it is likely not a causal cardiovascular risk factor. In healthy subjects, it limits lipid oxidation, protects endothelial cell functions/integrity, and exerts antiinflammatory/antiapoptotic effects. In patients with coronary disease or diabetes, it undergoes modifications/remodeling, resulting in dysfunctional high-density lipoprotein. We summarize recent findings about the regulation of its function and discuss the clinical implications. (Copyright © 2017 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Atherosclerosis; Coronary disease; Endothelial function; HDL function; Immune response |
| المشرفين على المادة: | 0 (Lipoproteins, HDL) |
| تواريخ الأحداث: | Date Created: 20180404 Date Completed: 20180918 Latest Revision: 20180918 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.ccl.2017.12.013 |
| PMID: | 29609761 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1558-2264 |
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| DOI: | 10.1016/j.ccl.2017.12.013 |