دورية أكاديمية
Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters.
العنوان: | Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters. |
---|---|
المؤلفون: | Yahouédéhou SCMA; Laboratório de Hematologia, Genética e Biologia Computacional (LHGB), Fiocruz Bahia-Instituto Gonçalo Moniz (IGM), Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, Brazil.; Laboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo 147, Ondina, 40170-115 Salvador, BA, Brazil., Carvalho MOS; Laboratório de Hematologia, Genética e Biologia Computacional (LHGB), Fiocruz Bahia-Instituto Gonçalo Moniz (IGM), Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, Brazil., Oliveira RM; Laboratório de Hematologia, Genética e Biologia Computacional (LHGB), Fiocruz Bahia-Instituto Gonçalo Moniz (IGM), Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, Brazil., Santiago RP; Laboratório de Hematologia, Genética e Biologia Computacional (LHGB), Fiocruz Bahia-Instituto Gonçalo Moniz (IGM), Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, Brazil., da Guarda CC; Laboratório de Hematologia, Genética e Biologia Computacional (LHGB), Fiocruz Bahia-Instituto Gonçalo Moniz (IGM), Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, Brazil., Carvalho SP; Laboratório de Hematologia, Genética e Biologia Computacional (LHGB), Fiocruz Bahia-Instituto Gonçalo Moniz (IGM), Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, Brazil., Ferreira JRD; Laboratório de Hematologia, Genética e Biologia Computacional (LHGB), Fiocruz Bahia-Instituto Gonçalo Moniz (IGM), Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, Brazil., Aleluia MM; Laboratório de Hematologia, Genética e Biologia Computacional (LHGB), Fiocruz Bahia-Instituto Gonçalo Moniz (IGM), Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, Brazil., Adorno EV; Laboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo 147, Ondina, 40170-115 Salvador, BA, Brazil., Gonçalves MS; Laboratório de Hematologia, Genética e Biologia Computacional (LHGB), Fiocruz Bahia-Instituto Gonçalo Moniz (IGM), Rua Waldemar Falcão 121, Candeal, 40296-710 Salvador, BA, Brazil.; Laboratório de Pesquisa em Anemia (LPA), Departamento de Análises Clínicas, Faculdade de Farmácia, Universidade Federal da Bahia, Rua Barão do Jeremoabo 147, Ondina, 40170-115 Salvador, BA, Brazil. |
المصدر: | Disease markers [Dis Markers] 2018 Jan 28; Vol. 2018, pp. 6105691. Date of Electronic Publication: 2018 Jan 28 (Print Publication: 2018). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Hindawi Pub. Corp Country of Publication: United States NLM ID: 8604127 Publication Model: eCollection Cited Medium: Internet ISSN: 1875-8630 (Electronic) Linking ISSN: 02780240 NLM ISO Abbreviation: Dis Markers Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2015- : New York, NY : Hindawi Pub. Corp. Original Publication: Chichester ; New York : Wiley, c1983- |
مواضيع طبية MeSH: | Polymorphism, Single Nucleotide*, Anemia, Sickle Cell/*drug therapy , Antisickling Agents/*therapeutic use , Hydroxyurea/*therapeutic use, Adolescent ; Adult ; Anemia, Sickle Cell/genetics ; Biomarkers/analysis ; Child ; Child, Preschool ; Cytochrome P-450 CYP2E1/genetics ; Female ; Glutathione Transferase/genetics ; Humans ; Male ; Middle Aged ; Peroxidase/genetics ; Young Adult |
مستخلص: | This study investigated associations between SNPs in genes encoding metabolizing drug enzymes and laboratory parameters in sickle cell anemia patients under hydroxyurea (SCA-HU + ). We evaluated hematologic and biochemical parameters by electronic methods and SNPs by PCR-RFLP and multiplex PCR in 35 SCA-HU + patients and 67 SCA-HU - patients. The HbS, total cholesterol, lactate dehydrogenase, aspartate aminotransferase, total bilirubin and fractions levels, and leukocyte, eosinophil, monocyte, and erythroblast counts were reduced in SCA-HU + patients ( p < 0.05). Moreover, they presented higher HbF, C-reactive protein, and ferritin levels and elevated MCH and MCV values ( p < 0.05). Genotype frequencies of variants GA + AA of MPO -463G>A and c1c2 + c2c2 of CYP2E1 -1293G>C/-1053C>T were higher in SCA-HU + patients ( p < 0.05). Independent associations were found between the variant A allele and lower total cholesterol, between c2 allele and low alpha-1 antitrypsin and between the null GSTT1 variant and high indirect and total bilirubin in SCA-HU + patients. In SCA-HU - patients, independent associations were found between the variant A allele and high uric acid and between c2 allele and high urea. Our results suggest that SNPs MPO -463G>A, CYP2E1 -1293G>C/-1053C>T, and GSTT1 can be associated with alterations in lipid, inflammatory, renal, hemolytic, and hepatic profiles. However, further studies are needed to elucidate these associations. |
References: | Rev Bras Hematol Hemoter. 2014 Mar-Apr;36(2):121-5. (PMID: 25030818) Blood. 2000 Jan 1;95(1):360-2. (PMID: 10607725) Curr Top Med Chem. 2005;5(7):665-73. (PMID: 16101427) Biochem Biophys Res Commun. 1984 Jan 30;118(2):409-15. (PMID: 6704084) Infect Genet Evol. 2014 Jun;24:34-40. (PMID: 24607341) Antimicrob Agents Chemother. 2016 Aug 22;60(9):5285-93. (PMID: 27324775) PLoS One. 2017 Feb 24;12(2):e0168981. (PMID: 28235038) J Cell Mol Med. 2015 Sep;19(9):2136-42. (PMID: 25945422) Rev Bras Hematol Hemoter. 2014 Sep-Oct;36(5):315-8. (PMID: 25305161) World J Gastroenterol. 2007 Nov 21;13(43):5725-30. (PMID: 17963298) Clin Gastroenterol Hepatol. 2010 Jun;8(6):483-9; quiz e70. (PMID: 20215064) Br J Haematol. 2002 Feb;116(2):436-44. (PMID: 11841449) Coll Antropol. 2011 Jun;35(2):385-8. (PMID: 21755707) Arh Hig Rada Toksikol. 2009 Jun;60(2):217-42. (PMID: 19581216) Ren Fail. 2016 Oct;38(9):1455-1461. (PMID: 27498857) Pediatr Blood Cancer. 2015 Jun;62(6):1017-23. (PMID: 25546091) J Am Soc Hypertens. 2015 Nov;9(11):902-6. (PMID: 26431910) Anticancer Res. 2009 May;29(5):1709-14. (PMID: 19443391) Br J Haematol. 2014 Jan;164(2):286-95. (PMID: 24383847) Curr Med Chem. 2003 Mar;10(6):437-52. (PMID: 12570692) Am J Hematol. 1989 Sep;32(1):66-9. (PMID: 2757004) Ann Oncol. 2002;13 Suppl 1:34-9. (PMID: 12078900) Eur J Pediatr. 2008 Jan;167(1):57-61. (PMID: 17318621) J Blood Transfus. 2015;2015:720389. (PMID: 25685597) Gene. 2013 May 25;521(1):105-10. (PMID: 23458878) J Investig Med. 2012 Jan;60(1):18-22. (PMID: 21997310) Br J Haematol. 2010 May;149(3):436-45. (PMID: 20230401) Biochem Pharmacol. 2014 Jul 1;90(1):1-6. (PMID: 24837423) Chin J Cancer Res. 2012 Dec;24(4):317-22. (PMID: 23358185) Am J Pharmacogenomics. 2002;2(2):79-92. (PMID: 12083944) Biofactors. 2008;32(1-4):71-81. (PMID: 19096102) Asian Pac J Cancer Prev. 2013;14(9):5311-6. (PMID: 24175818) World J Gastroenterol. 2003 Nov;9(11):2612-5. (PMID: 14606109) Blood. 2010 Jul 1;115(26):5300-11. (PMID: 20223921) Pharmacogenet Genomics. 2010 Apr;20(4):257-68. (PMID: 20216336) Lipids Health Dis. 2017 Apr 11;16(1):74. (PMID: 28399852) Indian J Hematol Blood Transfus. 2016 Mar;32(1):104-9. (PMID: 26855516) Hum Cell. 2015 Jul;28(3):109-13. (PMID: 25697264) Pharmacogenomics J. 2007 Dec;7(6):386-94. (PMID: 17299377) Sao Paulo Med J. 2013;131(4):238-43. (PMID: 24141294) Am Heart J. 2001 Aug;142(2):336-9. (PMID: 11479475) Blood. 2002 Jan 1;99(1):10-4. (PMID: 11756146) Oxid Med Cell Longev. 2017;2017:4680732. (PMID: 28163821) Folia Biol (Praha). 2014;60(3):108-12. (PMID: 25056433) Lancet. 2010 Dec 11;376(9757):2018-31. (PMID: 21131035) Aliment Pharmacol Ther. 2015 Oct;42(7):912-21. (PMID: 26235444) Br J Haematol. 2010 Mar;148(5):797-804. (PMID: 19995398) Blood. 2013 Jan 3;121(1):243-4. (PMID: 23287628) N Engl J Med. 2000 Mar 23;342(12):836-43. (PMID: 10733371) Rev Bras Hematol Hemoter. 2012;34(6):421-5. (PMID: 23323065) PLoS One. 2013 Aug 14;8(8):e72077. (PMID: 23967276) |
المشرفين على المادة: | 0 (Antisickling Agents) 0 (Biomarkers) EC 1.11.1.7 (Peroxidase) EC 1.14.13.- (Cytochrome P-450 CYP2E1) EC 2.5.1.- (glutathione S-transferase T1) EC 2.5.1.18 (Glutathione Transferase) X6Q56QN5QC (Hydroxyurea) |
تواريخ الأحداث: | Date Created: 20180406 Date Completed: 20180910 Latest Revision: 20240315 |
رمز التحديث: | 20240315 |
مُعرف محوري في PubMed: | PMC5829363 |
DOI: | 10.1155/2018/6105691 |
PMID: | 29619129 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1875-8630 |
---|---|
DOI: | 10.1155/2018/6105691 |