دورية أكاديمية
NS Segment of a 1918 Influenza A Virus-Descendent Enhances Replication of H1N1pdm09 and Virus-Induced Cellular Immune Response in Mammalian and Avian Systems.
العنوان: | NS Segment of a 1918 Influenza A Virus-Descendent Enhances Replication of H1N1pdm09 and Virus-Induced Cellular Immune Response in Mammalian and Avian Systems. |
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المؤلفون: | Petersen H; Clinic for Poultry, University of Veterinary Medicine Hannover, Hanover, Germany., Mostafa A; Institute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany.; Center of Scientific Excellence for Influenza Viruses, National Research Centre (NRC), Cairo, Egypt., Tantawy MA; Institute for Experimental Infection Research, TWINCORE Centre for Experimental and Clinical Infection Research, Hanover, Germany.; Department of Hormones, Medical Research Division, National Research Centre, Cairo, Egypt., Iqbal AA; Institute for Experimental Infection Research, TWINCORE Centre for Experimental and Clinical Infection Research, Hanover, Germany.; Helmholtz Centre for Infection Research, Braunschweig, Germany., Hoffmann D; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald, Germany., Tallam A; Institute for Experimental Infection Research, TWINCORE Centre for Experimental and Clinical Infection Research, Hanover, Germany., Selvakumar B; Max-Planck Laboratory for Heart and Lung Research, Instituto de Investigación en Biomedicina de Buenos Aires (IBioBA) - CONICET-Partner Institute of the Max Planck Society, Buenos Aires, Argentina., Pessler F; Institute for Experimental Infection Research, TWINCORE Centre for Experimental and Clinical Infection Research, Hanover, Germany.; Helmholtz Centre for Infection Research, Braunschweig, Germany., Beer M; Institute of Diagnostic Virology, Friedrich-Loeffler-Institut, Greifswald, Germany., Rautenschlein S; Clinic for Poultry, University of Veterinary Medicine Hannover, Hanover, Germany., Pleschka S; Institute of Medical Virology, Justus Liebig University Giessen, Giessen, Germany. |
المصدر: | Frontiers in microbiology [Front Microbiol] 2018 Mar 22; Vol. 9, pp. 526. Date of Electronic Publication: 2018 Mar 22 (Print Publication: 2018). |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101548977 Publication Model: eCollection Cited Medium: Print ISSN: 1664-302X (Print) Linking ISSN: 1664302X NLM ISO Abbreviation: Front Microbiol Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Original Publication: Lausanne : Frontiers Research Foundation |
مستخلص: | The 2009 pandemic influenza A virus (IAV) H1N1 strain (H1N1pdm09) has widely spread and is circulating in humans and swine together with other human and avian IAVs. This fact raises the concern that reassortment between H1N1pdm09 and co-circulating viruses might lead to an increase of H1N1pdm09 pathogenicity in different susceptible host species. Herein, we explored the potential of different NS segments to enhance the replication dynamics, pathogenicity and host range of H1N1pdm09 strain A/Giessen/06/09 (Gi-wt). The NS segments were derived from (i) human H1N1- and H3N2 IAVs, (ii) highly pathogenic- (H5- or H7-subtypes) or (iii) low pathogenic avian influenza viruses (H7- or H9-subtypes). A significant increase of growth kinetics in A549 (human lung epithelia) and NPTr (porcine tracheal epithelia) cells was only noticed in vitro for the reassortant Gi-NS-PR8 carrying the NS segment of the 1918-descendent A/Puerto Rico/8/34 (PR8-wt, H1N1), whereas all other reassortants showed either reduced or comparable replication efficiencies. Analysis using ex vivo tracheal organ cultures of turkeys (TOC-Tu), a species susceptible to IAV H1N1 infection, demonstrated increased replication of Gi-NS-PR8 compared to Gi-wt. Also, Gi-NS-PR8 induced a markedly higher expression of immunoregulatory and pro-inflammatory cytokines, chemokines and interferon-stimulated genes in A549 cells, THP-1-derived macrophages (dHTP) and TOC-Tu. In vivo , Gi-NS-PR8 induced an earlier onset of mortality than Gi-wt in mice, whereas, 6-week-old chickens were found to be resistant to both viruses. These data suggest that the specific characteristics of the PR8 NS segments can impact on replication, virus induced cellular immune responses and pathogenicity of the H1N1pdm09 in different avian and mammalian host species. |
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فهرسة مساهمة: | Keywords: H1N1pdm09; NS segment; influenza virus; innate immunity; reassortment |
تواريخ الأحداث: | Date Created: 20180407 Latest Revision: 20200929 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC5874506 |
DOI: | 10.3389/fmicb.2018.00526 |
PMID: | 29623073 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1664-302X |
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DOI: | 10.3389/fmicb.2018.00526 |